Intracellular innate immune receptors: Life inside the cell

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

Cross talk between intracellular pathogens and cell death

(2020) Benjamin Demarco et al.   IMMUNOLOGICAL REVIEWS

Pyroptotic and non-pyroptotic effector functions of caspase-11

(2020) Arwa Abu Khweek et al.   IMMUNOLOGICAL REVIEWS

The role of innate immunity in Alzheimer's disease

(2020) Hannah E. Ennerfelt et al.   IMMUNOLOGICAL REVIEWS

AIM2 in health and disease: Inflammasome and beyond

(2020) Puja Kumari et al.   IMMUNOLOGICAL REVIEWS

The microbiome and cytosolic innate immune receptors

(2020) Timur Liwinski et al.   IMMUNOLOGICAL REVIEWS

The NLRP1 and CARD8 inflammasomes

(2020) Cornelius Y. Taabazuing et al.   IMMUNOLOGICAL REVIEWS

Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis

(2020) Valerie Harrington et al.   IMMUNOLOGICAL REVIEWS

Nuclear innate sensors for nucleic acids in immunity and inflammation

(2020) Hongyu Lin et al.   IMMUNOLOGICAL REVIEWS

NOD1 and NOD2 in inflammatory and infectious diseases

(2020) Bruno C. Trindade et al.   IMMUNOLOGICAL REVIEWS

Primary immunodeficiencies in cytosolic pattern‐recognition receptor pathways: Toward host‐directed treatment strategies

(2020) Caspar I. Made et al.   IMMUNOLOGICAL REVIEWS

The pyrin inflammasome and the Yersinia effector interaction

(2020) Haleema S. Malik et al.   IMMUNOLOGICAL REVIEWS

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Min Zheng et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer

(2020) Callum Kay et al.   IMMUNOLOGICAL REVIEWS

What came first, the virus or the egg: Innate immunity during viral coinfections

(2020) Meagan D. Rippee‐Brooks et al.   IMMUNOLOGICAL REVIEWS

Therapeutic modulation of inflammasome pathways

(2020) Dhruv Chauhan et al.   IMMUNOLOGICAL REVIEWS

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

(2020) Min Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Parimal Samir et al.   Frontiers in Cellular and Infection Microbiology

Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

(2020) Rajendra Karki et al.   JCI Insight

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRF8 Regulates Transcription of Naip s for NLRC4 Inflammasome Activation

(2018) Rajendra Karki et al.   CELL

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

(2018) Deepika Sharma et al.   GASTROENTEROLOGY

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

(2017) Sannula Kesavardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

(2016) Daniel F. Aubert et al.   Cell Host & Microbe

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

(2016) Prajwal Gurung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

An NLRP3 inflammasome–triggered Th2-biased adaptive immune response promotes leishmaniasis

(2015) Prajwal Gurung et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Dietary modulation of the microbiome affects autoinflammatory disease

(2014) John R. Lukens et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

(2013) Djalma S Lima-Junior et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS