Structural basis of species-selective antagonist binding to the succinate receptor

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

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A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

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Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

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Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis

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Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

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Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

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GPR91: expanding the frontiers of Krebs cycle intermediates

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GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Insight into SUCNR1 (GPR91) structure and function

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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

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Two disparate ligand-binding sites in the human P2Y1 receptor

(2015) Dandan Zhang et al.   NATURE

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

A general protocol for the generation of Nanobodies for structural biology

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Deciphering key features in protein structures with the new ENDscript server

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

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Discovery of a potent and selective small molecule hGPR91 antagonist

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Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

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Crystallizing membrane proteins using lipidic mesophases

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Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY