Bystander CD4+ T cells: crossroads between innate and adaptive immunity

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

(2019) Juliana Komuczki et al.   IMMUNITY

A three course menu for ILC and bystander T cell activation

(2019) John W McGinty et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Innate-like Cytotoxic Function of Bystander-Activated CD8 + T Cells Is Associated with Liver Injury in Acute Hepatitis A

(2018) Jihye Kim et al.   IMMUNITY

Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis

(2018) Yuki Morimoto et al.   IMMUNITY

IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis

(2018) Sarah K. Whiteside et al.   JOURNAL OF IMMUNOLOGY

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Bystander T Cells: A Balancing Act of Friends and Foes

(2018) Sarah K. Whiteside et al.   TRENDS IN IMMUNOLOGY

Different interleukin-17-secreting Toll-like receptor+ T-cell subsets are associated with disease activity in multiple sclerosis

(2017) Thais B. Ferreira et al.   IMMUNOLOGY

Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

(2017) Naoko Mato et al.   Scientific Reports

IL-1–induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation

(2016) Chih-Chung Lin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+T Cells

(2016) Brian D. Sinnott et al.   JOURNAL OF IMMUNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

The Immunobiology of Interleukin-27

(2015) Hiroki Yoshida et al.   Annual Review of Immunology

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

(2015) Yusuke Endo et al.   IMMUNITY

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy

(2015) Payal Mittal et al.   JOURNAL OF IMMUNOLOGY

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis

(2015) Mukanthu H. Nyirenda et al.   JOURNAL OF IMMUNOLOGY

Innate immunological function of TH2 cells in vivo

(2015) Liying Guo et al.   NATURE IMMUNOLOGY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Loss of IFN-  Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

(2014) J. J. Sabatino et al.   JOURNAL OF IMMUNOLOGY

A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality

(2014) P Holmkvist et al.   Mucosal Immunology

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

(2014) Felix J. Hartmann et al.   Nature Communications

Toll-like receptor regulation of effector T lymphocyte function

(2013) Joseph M. Reynolds et al.   TRENDS IN IMMUNOLOGY

IL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13

(2012) Min-Jong Kang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

IL-12 family cytokines: immunological playmakers

(2012) Dario A A Vignali et al.   NATURE IMMUNOLOGY

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

(2012) T. W. Hand et al.   SCIENCE

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function

(2011) M. H. Nyirenda et al.   JOURNAL OF IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Bystander T cells in human immune responses to dengue antigens

(2010) Duangchan Suwannasaen et al.   BMC IMMUNOLOGY

Bystander stimulation of activated CD4+T cells of unrelated specificity following a booster vaccination with tetanus toxoid

(2010) Gianfranco Di Genova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

(2010) José M. González-Navajas et al.   JOURNAL OF CLINICAL INVESTIGATION

Encephalitogenic T-cells increase numbers of CNS T-cells regardless of antigen specificity by both increasing T-cell entry and preventing egress

(2010) Jason R. Lees et al.   JOURNAL OF NEUROIMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Regulating human Th17 cells via differential expression of IL-1 receptor

(2009) W.-W. Lee et al.   BLOOD

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

(2009) L. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology