microRNA27a-3p mediates reduction of the Wnt antagonist sFRP-1 in systemic sclerosis

The Role of Epigenetic Modifications in Systemic Sclerosis: A Druggable Target

(2019) John Henderson et al.   TRENDS IN MOLECULAR MEDICINE

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

Leptin up-regulates microRNA-27a/b-3p level in hepatic stellate cells

(2018) Ziqiang Li et al.   EXPERIMENTAL CELL RESEARCH

Aortic carboxypeptidase–like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis

(2018) Toshiaki Teratani et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting TLRs and the inflammasome in systemic sclerosis

(2018) John Henderson et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of collagen production by ICG-001, a small molecule inhibitor for Wnt/β-catenin signaling, in skin fibroblasts

(2017) Kyung-Il Kim et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Systemic sclerosis

(2017) Christopher P Denton et al.   LANCET

Epigenetics in fibrosis

(2017) Steven O’Reilly   MOLECULAR ASPECTS OF MEDICINE

Interplay between genetic and epigenetic mechanisms in rheumatoid arthritis

(2017) Mojca Frank-Bertoncelj et al.   Epigenomics

MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2

(2016) Lin Zhou et al.   Oncotarget

MicroRNA-27a Induces Mesangial Cell Injury by Targeting of PPARγ and its In Vivo Knockdown Prevents Progression of Diabetic Nephropathy

(2016) Lina Wu et al.   Scientific Reports

Systemic sclerosis

(2015) Yannick Allanore et al.   Nature Reviews Disease Primers

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

(2014) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 (IL-6) Trans Signaling Drives a STAT3-dependent Pathway That Leads to Hyperactive Transforming Growth Factor-β (TGF-β) Signaling Promoting SMAD3 Activation and Fibrosis via Gremlin Protein

(2014) Steven O'Reilly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Frizzled-related Protein 1 (Sfrp1) Regulates the Progression of Renal Fibrosis in a Mouse Model of Obstructive Nephropathy

(2014) Makoto Matsuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

(2013) Clara Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative

(2013) Frank van den Hoogen et al.   ANNALS OF THE RHEUMATIC DISEASES

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

(2010) Jun Wei et al.   CURRENT OPINION IN RHEUMATOLOGY

Epithelial Cells Promote Fibroblast Activation via IL-1α in Systemic Sclerosis

(2010) Nima Aden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One