Cardiopulmonary Bypass Induces Acute Lung Injury via the High-Mobility Group Box 1/Toll-Like Receptor 4 Pathway

HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma

(2019) Yanbin Wang et al.   DISEASE MARKERS

NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass

(2018) Lei Hou et al.   LABORATORY INVESTIGATION

The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

(2018) Lu Meng et al.   MOLECULAR IMMUNOLOGY

Indinavir Plus Methylprednisolone Ameliorates Experimental Acute Lung Injury In Vitro and In Vivo

(2018) Yunxia Ji et al.   SHOCK

Pretreatment with Erythropoietin Attenuates Lung Ischemia/Reperfusion Injury via Toll-Like Receptor-4/Nuclear Factor-κB (TLR4/NF-κB) Pathway

(2018) Qian He et al.   MEDICAL SCIENCE MONITOR

p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice

(2018) Young-Su Yi et al.   EBioMedicine

Effect of hyperbaric oxygen therapy on HMGB1/NF-κB expression and prognosis of acute spinal cord injury: A randomized clinical trial

(2018) Lei Sun et al.   NEUROSCIENCE LETTERS

Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury

(2017) Ioannis Bougioukas et al.   JOURNAL OF INVESTIGATIVE SURGERY

Alpha7 Nicotine Acetylcholine Receptor Agonist PNU-282987 Attenuates Acute Lung Injury in a Cardiopulmonary Bypass Model in Rats

(2017) Jiaxi Ge et al.   SHOCK

Electroacupuncture Pretreatment Attenuates Acute Lung Injury Through α7 Nicotinic Acetylcholine Receptor-Mediated Inhibition of HMGB1 Release in Rats after Cardiopulmonary Bypass

(2017) Zhankui Wang et al.   SHOCK

Anti-high mobility group box-1 (HMGB1) antibody inhibits hemorrhage-induced brain injury and improved neurological deficits in rats

(2017) Dengli Wang et al.   Scientific Reports

Tissue damage negatively regulates LPS-induced macrophage necroptosis

(2016) Z Li et al.   CELL DEATH AND DIFFERENTIATION

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats

(2016) Jun Haruma et al.   Scientific Reports

Viral Vectors for Gene Therapy: Translational and Clinical Outlook

(2015) Melissa A. Kotterman et al.   Annual Review of Biomedical Engineering

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Novel Role of Resveratrol

(2014) Wei Xu et al.   SHOCK

High Mobility Group Box–1 Mediates Hyperoxia-Induced Impairment ofPseudomonas aeruginosaClearance and Inflammatory Lung Injury in Mice

(2013) Vivek S. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury

(2013) Zhongwei Yang et al.   LABORATORY INVESTIGATION

Toll-Like Receptor 4 Mediates Acute Lung Injury Induced by High Mobility Group Box-1

(2013) Yuxiao Deng et al.   PLoS One

Mechanical Ventilation Enhances HMGB1 Expression in an LPS-Induced Lung Injury Model

(2013) Ning Ding et al.   PLoS One

The Protective Effect of PNU-282987, a Selective Alpha7 Nicotinic Acetylcholine Receptor Agonist, on the Hepatic Ischemia-Reperfusion Injury is Associated with the Inhibition of High-Mobility Group Box 1 Protein Expression and NF-κB Activation in Mice

(2013) Fujing Li et al.   SHOCK

Systemic Involvement of High-Mobility Group Box 1 Protein and Therapeutic Effect of Anti–High-Mobility Group Box 1 Protein Antibody in a Rat Model of Crush Injury

(2012) Junya Shimazaki et al.   SHOCK

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

The Preventative Role of Curcumin on the Lung Inflammatory Response Induced by Cardiopulmonary Bypass in Rats

(2011) Kun Liu et al.   JOURNAL OF SURGICAL RESEARCH

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effect of High-Mobility Group Box 1 Blockade on Acute Liver Failure in Rats

(2010) Kiminori Takano et al.   SHOCK

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2

(2009) Yuehua Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS

A Phase II Multicenter Double-Blind Placebo-Controlled Study of Ethyl Pyruvate in High-Risk Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

(2008) Elliott Bennett-Guerrero et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA