Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer

RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer

(2020) Mrinmoyee Majumder et al.   PLoS Genetics

FXR1 expression domain in Wilms tumor

(2019) Hannah M. Phelps et al.   JOURNAL OF PEDIATRIC SURGERY

FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG

(2019) Shuo Cao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The RNA-binding protein FXR1 modulates prostate cancer progression by regulating FBXO4

(2019) Hongwen Cao et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats

(2019) Carla E M Golden et al.   CEREBRAL CORTEX

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

(2018) X. Shawn Liu et al.   CELL

Immunohistochemical Expression of FXR1 in Canine Normal Tissues and Melanomas

(2018) Laura Nordio et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Handling FMRP and its molecular partners: Structural insights into Fragile X Syndrome

(2018) Ilda D'Annessa et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation

(2018) Anouar Khayachi et al.   Nature Communications

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

(2018) Jivan Khlghatyan et al.   Frontiers in Molecular Neuroscience

Intragenic FMR1 disease-causing variants: a significant mutational mechanism leading to Fragile-X syndrome

(2017) Angélique Quartier et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The interaction of GSK3B and FXR1 genotypes may influence the mania and depression dimensions in mood disorders

(2017) Alexandre Bureau et al.   JOURNAL OF AFFECTIVE DISORDERS

Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome

(2017) Chantal Sellier et al.   NEURON

Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice

(2017) Victor Sabanov et al.   NEUROPHARMACOLOGY

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells

(2017) Francesca Zalfa et al.   Cell Death & Disease

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

(2017) Shuo Qie et al.   Nature Communications

Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci

(2017) Atsushi Takata et al.   Nature Communications

FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

(2017) Yichao Fan et al.   eLife

Fragile X syndrome

(2017) Randi J. Hagerman et al.   Nature Reviews Disease Primers

The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y

(2016) Yun Ma et al.   GENE

A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region

(2016) Xiaohua Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Frameshift Mutation of FXR1 Encoding a RNA-Binding Protein in Gastric and Colorectal Cancers with Microsatellite Instability

(2016) Yun Sol Jo et al.   PATHOLOGY & ONCOLOGY RESEARCH

Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons

(2016) Ricardos Tabet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma

(2016) Erlinda Fernández et al.   PLoS Genetics

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

(2016) Mrinmoyee Majumder et al.   PLoS Genetics

Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome

(2016) Elisabetta Tabolacci et al.   Genes

Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene

(2016) Maitane Barasoain et al.   Genes

MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion

(2015) Daniele Di Marino et al.   Journal of Chemical Theory and Computation

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression

(2015) E. Fernandez et al.   JOURNAL OF NEUROSCIENCE

Systematic investigation of hierarchical phosphorylation by protein kinase CK2

(2015) Nicole St-Denis et al.   Journal of Proteomics

Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease

(2015) Antonella Borreca et al.   MOLECULAR NEUROBIOLOGY

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers

(2015) Jun Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FXR1P is a GSK3β substrate regulating mood and emotion processing

(2015) Thomas Del’Guidice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders

(2015) Timothy D. Folsom et al.   SCHIZOPHRENIA RESEARCH

GABA receptor subunit distribution and FMRP–mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism

(2015) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish

(2015) Adi Shamay-Ramot et al.   PLoS Genetics

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

(2014) Roman Alpatov et al.   CELL

Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain

(2014) Leila K. Myrick et al.   HUMAN MOLECULAR GENETICS

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Fragile X Syndrome: From molecular pathology to therapy

(2014) Thomas Maurin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity

(2014) Christopher M. Bartley et al.   PLoS One

CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome

(2014) Sabiha Abekhoukh et al.   Frontiers in Cellular Neuroscience

FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation

(2014) Denise Cook et al.   Cell Reports

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

(2014) Alison Hamilton et al.   Molecular Brain

Fragile X mental retardation protein expression in Alzheimer’s disease

(2014) Abigail J. Renoux et al.   Frontiers in Genetics

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step

(2013) Kiranmai Gumireddy et al.   EMBO JOURNAL

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

(2013) Rossella Lucá et al.   EMBO Molecular Medicine

Genome wide assessment of mRNA in astrocyte protrusions by direct RNA sequencing reveals mRNA localization for the intermediate filament protein nestin

(2013) Rune Thomsen et al.   GLIA

Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function

(2013) Daniele Di Marino et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

(2013) Silvia De Rubeis et al.   NEURON

Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions

(2012) Michael R. Akins et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses

(2012) Caroline Lacoux et al.   NUCLEIC ACIDS RESEARCH

Inhibition of GSK3  improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

(2011) W. Guo et al.   HUMAN MOLECULAR GENETICS

Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

(2011) Ravi S. Muddashetty et al.   MOLECULAR CELL

Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus

(2011) Denise Cook et al.   PLoS One

Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders

(2011) Y. Sakai et al.   Science Translational Medicine

Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males

(2010) Stephen C. Collins et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA

(2010) E. Blackwell et al.   HUMAN MOLECULAR GENETICS

A Functional Requirement for PAK1 Binding to the KH(2) Domain of the Fragile X Protein-Related FXR1

(2010) Evonne Say et al.   MOLECULAR CELL

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

(2010) Maile R Brown et al.   NATURE NEUROSCIENCE

Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2

(2010) Melanie A. Adams-Cioaba et al.   PLoS One

Fragile X mental retardation protein levels are decreased in major psychiatric disorders

(2010) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

A study of the ultrastructure of Fragile-X-related proteins

(2009) Ljiljana Sjekloća et al.   BIOCHEMICAL JOURNAL

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs

(2009) J. C. Darnell et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of FMRP inhibits association with Dicer

(2009) A. Cheever et al.   RNA

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

(2008) Ilaria Napoli et al.   CELL

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer

(2008) Marie-Cécile Didiot et al.   NUCLEIC ACIDS RESEARCH

Abnormal Striatal GABA Transmission in the Mouse Model for the Fragile X Syndrome

(2007) Diego Centonze et al.   BIOLOGICAL PSYCHIATRY