RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase

(2016) Sandhya Sanduja et al.   Aging-US

Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis

(2015) Jing Wang et al.   BMC GENOMICS

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53 -Defective Tumors to Chemotherapy

(2015) Ian G. Cannell et al.   CANCER CELL

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer

(2015) D. M. Neskey et al.   CANCER RESEARCH

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers

(2015) Jun Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human dyskerin: beyond telomeres

(2014) Alberto Angrisani et al.   BIOLOGICAL CHEMISTRY

Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence

(2014) A. A. Osman et al.   MOLECULAR CANCER THERAPEUTICS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA damage: RNA-binding proteins protect from near and far

(2014) Martin Dutertre et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dissecting the expression landscape of RNA-binding proteins in human cancers

(2014) Bobak Kechavarzi et al.   GENOME BIOLOGY

Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β

(2013) Yazan Hassona et al.   CARCINOGENESIS

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation

(2013) C Li et al.   Cell Death & Disease

A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating p21/Cdkn1a/Cip1/Waf1 mRNA Stability

(2013) Laetitia Davidovic et al.   PLoS Genetics

At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence

(2013) Ryosuke Ohsawa et al.   Frontiers in Genetics

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Structure, function and targeting of human telomere RNA

(2012) Yan Xu et al.   METHODS

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

G-quadruplexes in RNA biology

(2012) Stefania Millevoi et al.   Wiley Interdisciplinary Reviews-RNA

Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas

(2011) J. Zhang et al.   GENES & DEVELOPMENT

Caspase-mediated Cleavage of RNA-binding Protein HuR Regulates c-Myc Protein Expression after Hypoxic Stress

(2011) Sudha Talwar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere Dysfuction Promotes Metastasis in a TERC Null Mouse Model of Head and Neck Cancer

(2011) B. Bojovic et al.   MOLECULAR CANCER RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability

(2010) Ariane Scoumanne et al.   NUCLEIC ACIDS RESEARCH

Inducible response required for repair of low-dose radiation damage in human fibroblasts

(2010) S. Grudzenski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dyskeratosis congenita, stem cells and telomeres

(2009) Michael Kirwan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Telomerase deficiency and cancer susceptibility syndromes

(2009) Rosario Perona et al.   Clinical & Translational Oncology

Cellular senescence in oral cancer and precancer and treatment implications: A review

(2008) Julian Campo-Trapero et al.   ACTA ONCOLOGICA

ExogenousTERCalone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients

(2008) Michael Kirwan et al.   BRITISH JOURNAL OF HAEMATOLOGY