The SWI/SNF ATPase BRG1 stimulates DNA end resection and homologous recombination by reducing nucleosome density at DNA double strand breaks and by promoting the recruitment of the CtIP nuclease

A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks

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E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair

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Homologous Recombination and the Formation of Complex Genomic Rearrangements

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Therapeutic targeting and patient selection for cancers with homologous recombination defects

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The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes

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Drugging the Cancers Addicted to DNA Repair

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The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast

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A global view of meiotic double-strand break end resection

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Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer

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Drugging the Cancers Addicted to DNA Repair

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RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1

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Exploiting DNA repair defects for novel cancer therapies

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When Genome Maintenance Goes Badly Awry

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The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer

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Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

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ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

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SWI/SNF complexes are required for full activation of the DNA-damage response

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BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51

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Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

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ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair

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Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

(2014) A. R. Venkitaraman   SCIENCE

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

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A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

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Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

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Repair of Strand Breaks by Homologous Recombination

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The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation

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Overcoming the chromatin barrier to end resection

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A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells

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An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis

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The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

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The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

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γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

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Chromatin dynamics and the repair of DNA double strand breaks

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Mammalian Ino80 Mediates Double-Strand Break Repair through Its Role in DNA End Strand Resection

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The MRE11 complex: starting from the ends

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PARP inhibition: targeting the Achillesʼ heel of DNA repair to treat germline and sporadic ovarian cancers

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A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair

(2010) Han-Sae Lee et al.   EMBO JOURNAL

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

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Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

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Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

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