Structural–functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding

J-Domain Proteins in Bacteria and Their Viruses

(2020) Roland Barriot et al.   JOURNAL OF MOLECULAR BIOLOGY

Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function

(2020) Si Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol bound Plasmodium falciparum co-chaperone ‘PFA0660w’ complexes with major virulence factor ‘PfEMP1’ via chaperone ‘PfHsp70-x’

(2019) Ankita Behl et al.   Scientific Reports

Cellular Functions and Mechanisms of Action of Small Heat Shock Proteins

(2019) Axel Mogk et al.   Annual Review of Microbiology

Selective Hsp70-Dependent Docking of Hsp104 to Protein Aggregates Protects the Cell from the Toxicity of the Disaggregase

(2019) Tomasz Chamera et al.   JOURNAL OF MOLECULAR BIOLOGY

Comparative proteomic analysis reveals drug resistance of Staphylococcus xylosus ATCC700404 under tylosin stress

(2019) Xin Liu et al.   BMC Veterinary Research

Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting

(2019) Mohammad Anas et al.   CELL STRESS & CHAPERONES

Uncoupling the Threading and Unfoldase Actions of Plasmodium HSP101 Reveals Differences in Export between Soluble and Insoluble Proteins

(2019) Kathryn M. Matthews et al.   mBio

Structural basis for client recognition and activity of Hsp40 chaperones

(2019) Yajun Jiang et al.   SCIENCE

HSPA1A conformational mutants reveal a conserved structural unit in Hsp70 proteins

(2019) Veronika Vandova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural insights into the binding mechanism of Plasmodium falciparum exported Hsp40-Hsp70 chaperone pair

(2019) Ankita Behl et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite

(2019) Jemma Day et al.   FASEB JOURNAL

Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding

(2018) Unekwu M. Yakubu et al.   BIOLOGICAL CHEMISTRY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes

(2018) Gerry Q. Tonkin-Hill et al.   PLOS BIOLOGY

Protein evolution speed depends on its stability and abundance and on chaperone concentrations

(2018) Luca Agozzino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif

(2018) Blessing Mabate et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Discovering Putative Prion-Like Proteins in Plasmodium falciparum: A Computational and Experimental Analysis

(2018) Irantzu Pallarès et al.   Frontiers in Microbiology

Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones

(2018) Matthias P Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

(2018) Wenli Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp70 - a master regulator in protein degradation

(2017) María Rosario Fernández-Fernández et al.   FEBS LETTERS

Plasmodium Hsp40 and human Hsp70: A potential cochaperone-chaperone complex

(2017) Payal Jha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins

(2017) Sreenivas Chavali et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins

(2017) Sreenivas Chavali et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

(2017) Nadinath B Nillegoda et al.   eLife

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

(2017) Duccio Malinverni et al.   eLife

The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle

(2017) David W. Cobb et al.   mSphere

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

(2016) Andrija Finka et al.   Annual Review of Biochemistry

Malaria: Biology and Disease

(2016) Alan F. Cowman et al.   CELL

Plasmodium species: master renovators of their host cells

(2016) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

The Malarial Exported PFA0660w Is an Hsp40 Co-Chaperone of PfHsp70-x

(2016) Michael O. Daniyan et al.   PLoS One

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes

(2016) Thomas Reid Alderson et al.   STRUCTURE

Trafficking of the exported P. falciparum chaperone PfHsp70x

(2016) Manuel Rhiel et al.   Scientific Reports

Functionality of Class A and Class B J-protein co-chaperones with Hsp70

(2015) Hyun Young Yu et al.   FEBS LETTERS

PFB0595w is a Plasmodium falciparum J protein that co-localizes with PfHsp70-1 and can stimulate its in vitro ATP hydrolysis activity

(2015) James M. Njunge et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Functional DnaK Dimer Is Essential for the Efficient Interaction with Hsp40 Heat Shock Protein

(2015) Evans Boateng Sarbeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Intramolecular and Intermolecular Interactions in Functional Regulation of the Hsp70 J-protein Co-Chaperone Sis1

(2015) Hyun Young Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Co-evolutionary analysis implies auxiliary functions of HSP110 inPlasmodium falciparum

(2015) Deeksha Bhartiya et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP

(2015) Jiao Yang et al.   STRUCTURE

Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity

(2014) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Interactive transcriptome analysis of malaria patients and infectingPlasmodium falciparum

(2014) Junya Yamagishi et al.   GENOME RESEARCH

Plasmodial Hsp40 and Hsp70 chaperones: current and future perspectives

(2014) E.-R. PESCE et al.   PARASITOLOGY

Interplay between Chaperones and Protein Disorder Promotes the Evolution of Protein Networks

(2014) Sebastian Pechmann et al.   PLoS Computational Biology

Combining crystallography and EPR: crystal and solution structures of the multidomain cochaperone DnaJ

(2013) Thomas R. M. Barends et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain

(2013) Francesco A. Aprile et al.   PLoS One

Asparagine Repeats in Plasmodium falciparum Proteins: Good for Nothing?

(2013) Vasant Muralidharan et al.   PLoS Pathogens

Structure, Function and Regulation of the Hsp90 Machinery

(2013) Johannes Buchner et al.   Biomedical Journal

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

(2012) Simone Külzer et al.   CELLULAR MICROBIOLOGY

The DNAJA2 Substrate Release Mechanism Is Essential for Chaperone-mediated Folding

(2012) Imad Baaklini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

An Exported Heat Shock Protein 40 Associates with Pathogenesis-Related Knobs in Plasmodium falciparum Infected Erythrocytes

(2012) Pragyan Acharya et al.   PLoS One

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum

(2011) María J López-Barragán et al.   BMC GENOMICS

The heat shock protein 40 family of the malaria parasite Plasmodium falciparum

(2011) Melanie Rug et al.   IUBMB LIFE

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface

(2011) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the different chaperone activities of the bacterial HSP70-HSP40 system using a thermolabile luciferase substrate

(2011) Sandeep K. Sharma et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state

(2010) Meiri Shida et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock

(2010) Melissa Botha et al.   CELL STRESS & CHAPERONES

Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte

(2010) Simone Külzer et al.   CELLULAR MICROBIOLOGY

Multiple Molecules of Hsc70 and a Dimer of DjA1 Independently Bind to an Unfolded Protein

(2010) Kazutoyo Terada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the blood-stage transcriptome ofPlasmodium falciparumusing RNA-Seq

(2010) Thomas D. Otto et al.   MOLECULAR MICROBIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp70-1 from Plasmodium falciparum: Protein stability, domain analysis and chaperone activity

(2009) Gauri Misra et al.   BIOPHYSICAL CHEMISTRY

The Mammalian Hsp40 ERdj3 Requires Its Hsp70 Interaction and Substrate-binding Properties to Complement Various Yeast Hsp40-dependent Functions

(2009) Shruthi S. Vembar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat Shock Protein 40: Structural Studies and Their Functional Implications

(2009) Jingzhi Li et al.   PROTEIN AND PEPTIDE LETTERS

The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns

(2008) Eva-Rachele Pesce et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functional Divergence between Co-chaperones of Hsc70

(2008) Stefan Tzankov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY