Journal
IUBMB LIFE
Volume 63, Issue 12, Pages 1081-1086Publisher
WILEY
DOI: 10.1002/iub.525
Keywords
malaria; Plasmodium; heat shock protein 40; DnaJ; chaperone; host cell subversion; protein transport
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Funding
- Australian National Health and Medical Research Council (NHMRC)
- Australian Research Council (ARC)
- Hugh D T Williamson Foundation
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Few diseases have had such a profound influence on human evolution and history as malaria. Despite intense efforts malaria infection continues to be a major killer. The causative agent of malaria, the unicellular eukaryote Plasmodium, displays a fascinating biology in which ubiquitous cellular concepts are modified to serve the particular needs of the malaria parasite. In this review, we explore how Plasmodium utilizes the heat shock protein 40 system, a chaperone system that ensures correct protein folding under normal and stress conditions. We highlight the peculiarities of the Plasmodium system and discuss whether any components of the system might be exploited for intervention strategies against this debilitating disease. (C) 2011 IUBMB IUBMB Life, 63(12): 1081-1086, 2011
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