Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target

(2018) Dirk M. Hermann et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

(2018) Min Hee Park et al.   NEURON

3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy

(2017) Erlen Lugo-Hernandez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

(2017) Sergei A. Novgorodov et al.   JOURNAL OF LIPID RESEARCH

Types A and B Niemann-Pick disease

(2017) Edward H. Schuchman et al.   MOLECULAR GENETICS AND METABOLISM

Acid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases

(2017) Aiping Bai et al.   Cell Death & Disease

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart

(2016) Martina Klevstig et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acid Sphingomyelinase–Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

(2015) Melissa A. Lopes Pinheiro et al.   JOURNAL OF IMMUNOLOGY

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

(2015) Huiming Peng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice

(2015) Josephine Herz et al.   STROKE

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

The ceramide system as a novel antidepressant target

(2014) Johannes Kornhuber et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Intercellular Adhesion Molecule 1 Engagement Modulates Sphingomyelinase and Ceramide, Supporting Uptake of Drug Carriers by the Vascular Endothelium

(2012) Daniel Serrano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Acid sphingomyelinase in macrophage biology

(2011) Jean-Philip Truman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The challenge to verify ceramide's role of apoptosis induction in human cardiomyocytes - a pilot study

(2011) Engin Usta et al.   Journal of Cardiothoracic Surgery

Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions

(2011) Josephine Herz et al.   NEUROBIOLOGY OF DISEASE

Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression

(2010) Guangwen Ren et al.   JOURNAL OF IMMUNOLOGY

Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers

(2008) C. Garnacho et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

(2008) X. Deng et al.   SCIENCE