Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models
Authors
Keywords
-
Journal
ARCHIVES OF TOXICOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-11
DOI
10.1007/s00204-020-02906-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A 300µm organotypic bone slice culture model for temporal investigation of endochondral osteogenesis
- (2019) Ute Schäfer et al. TISSUE ENGINEERING PART C-METHODS
- Haematopoietic stem cell activity and interactions with the niche
- (2019) Sandra Pinho et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pharmacological Inhibition of NFκB Reduces Prostate Cancer Related Osteoclastogenesis In Vitro and Osteolysis Ex Vivo
- (2019) Silvia Marino et al. CALCIFIED TISSUE INTERNATIONAL
- Risk of fracture with dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in real-world use: systematic review and meta-analysis of observational studies
- (2019) K. Hidayat et al. OSTEOPOROSIS INTERNATIONAL
- Culturing and Measuring Fetal and Newborn Murine Long Bones
- (2019) Veronica Uribe et al. Jove-Journal of Visualized Experiments
- Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty
- (2019) Sabrina Ehnert et al. Journal of Clinical Medicine
- GC–MS method for metabolic profiling of mouse femoral head articular cartilage reveals distinct effects of tissue culture and development
- (2019) A. Batushansky et al. OSTEOARTHRITIS AND CARTILAGE
- Hypoxia and mesenchymal stromal cells as key drivers of initial fracture healing in an equine in vitro fracture hematoma model
- (2019) Moritz Pfeiffenberger et al. PLoS One
- Short‐term hypoxia promotes vascularization in co‐culture system consisting of primary human osteoblasts and outgrowth endothelial cells
- (2019) Bin Ma et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Review of Animal Models of Comorbidities in Fracture‐Healing Research
- (2019) Melanie Haffner‐Luntzer et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Strategy for achieving standardized bone models
- (2019) Mikhael Hadida et al. BIOTECHNOLOGY AND BIOENGINEERING
- An Ex Vivo Bone Defect Model to Evaluate Bone Substitutes and Associated Bone Regeneration Processes
- (2019) Tim Klüter et al. TISSUE ENGINEERING PART C-METHODS
- The effects of diabetes therapy on bone: A clinical perspective
- (2018) Karim G. Kheniser et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin α5
- (2018) Meiyu Sun et al. Stem Cell Research & Therapy
- Clinical and Research Approaches to Treat Non-union Fracture
- (2018) Claudia Schlundt et al. Current Osteoporosis Reports
- From the Clinical Problem to the Basic Research—Co-Culture Models of Osteoblasts and Osteoclasts
- (2018) Sheng Zhu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Bi-directional Interactions between Inflammation and Coagulation in Fracture Hematoma
- (2018) Yaping Ma et al. TISSUE ENGINEERING PART B-REVIEWS
- Einschätzung der Auswirkungen eines Diabetes mellitus und einer Mangelernährung auf die postoperative Komplikationsrate und Lebensqualität von Patienten in einer unfallchirurgischen Schwerpunktklinik
- (2018) Elke Wintermeyer et al. Zeitschrift fur Orthopadie und Unfallchirurgie
- Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
- (2018) Isabel Fabregat et al. Frontiers in Oncology
- Diabetes pharmacotherapy and effects on the musculoskeletal system
- (2018) Evangelia Kalaitzoglou et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer
- (2018) Saba Choudhary et al. Scientific Reports
- Malnutrition – An underestimated factor in the inpatient treatment of traumatology and orthopedic patients
- (2017) Christoph Ihle et al. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
- The Effects of Pioglitazone on Bone Formation and Resorption Markers in Type 2 Diabetes Mellitus
- (2017) Hiroko Mori et al. INTERNAL MEDICINE
- TGF-β1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia
- (2017) Sabrina Ehnert et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Effect of anti-diabetic drugs on bone metabolism: Evidence from preclinical and clinical studies
- (2017) Mohammad Adil et al. Pharmacological Reports
- Effects of Lobeglitazone, a Novel Thiazolidinedione, on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus over 52 Weeks
- (2017) Soo Lim et al. Diabetes & Metabolism Journal
- Bone marrow adipocytes
- (2017) Mark C. Horowitz et al. Adipocyte
- The effects of dipeptidyl peptidase-4 inhibitors on bone fracture among patients with type 2 diabetes mellitus: A network meta-analysis of randomized controlled trials
- (2017) Jun Yang et al. PLoS One
- Antioxidant and bone repair properties of quercetin-functionalized hydroxyapatite: An in vitro osteoblast–osteoclast–endothelial cell co-culture study
- (2016) Lucia Forte et al. Acta Biomaterialia
- Niche heterogeneity in the bone marrow
- (2016) Alexander Birbrair et al. Annals of the New York Academy of Sciences
- Diagnostic Tests: Secondary osteoporosis
- (2016) Australian Prescriber
- The influence of calcitonin gene-related peptide on markers of bone metabolism in MG-63 osteoblast-like cells co-cultured with THP-1 macrophage-like cells under virtually osteolytic conditions
- (2016) Heidrun Jablonski et al. BMC MUSCULOSKELETAL DISORDERS
- Sweet and brittle — Diabetes mellitus and the skeleton
- (2016) Lorenz C. Hofbauer et al. BONE
- Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus
- (2016) Nelson B. Watts et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Role of myeloid early endothelial progenitor cells in bone formation and osteoclast differentiation in tissue construct based on hydroxyapatite poly(ester-urethane) scaffolds
- (2016) Yang Shi et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Establishment of a 3D-dynamic osteoblasts–osteoclasts co-culture model to simulate the jawbone microenvironment in vitro
- (2016) Letizia Penolazzi et al. LIFE SCIENCES
- TGF-β: the master regulator of fibrosis
- (2016) Xiao-ming Meng et al. Nature Reviews Nephrology
- Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis
- (2016) Michael K. Lichtman et al. WOUND REPAIR AND REGENERATION
- Retrospektive Analyse von Diabetikern im Hinblick auf Behandlungsdauer und Behandlungskosten in einem überregionalen Traumazentrum
- (2016) S. Pscherer et al. Zeitschrift fur Orthopadie und Unfallchirurgie
- An in vitro 3D bone metastasis model by using a human bone tissue culture and human sex-related cancer cells
- (2016) Francesca Salamanna et al. Oncotarget
- A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site
- (2016) Tatsuya Kunimoto et al. Scientific Reports
- The use of rats and mice as animal models in ex vivo bone growth and development studies
- (2016) A. A. Abubakar et al. Bone & Joint Research
- Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant
- (2016) Gauri Tendulkar et al. Jove-Journal of Visualized Experiments
- Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
- (2016) Dean A. Houston et al. Jove-Journal of Visualized Experiments
- Fracture risk in patients with type 2 diabetes under different antidiabetic treatment regimens: a retrospective database analysis in primary care
- (2016) Karel Kostev et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture
- (2015) Lili Wu et al. Acta Biomaterialia
- Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur
- (2015) Naoki Okubo et al. Acta Orthopaedica
- A 3Dex vivomandible slice system for longitudinal culturing of transplanted dental pulp progenitor cells
- (2015) John S. Colombo et al. CYTOMETRY PART A
- Sulfonylureas and risk of falls and fractures among nursing home residents with type 2 diabetes mellitus
- (2015) Kate L. Lapane et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Sulfonylurea Use and Risk of Hip Fractures Among Elderly Men and Women with Type 2 Diabetes
- (2015) Swapnil N. Rajpathak et al. DRUGS & AGING
- Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation – Description of a novel in vitro model
- (2015) Sabrina Ehnert et al. EXPERIMENTAL CELL RESEARCH
- Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study
- (2015) Sujata Mohanty et al. INDIAN JOURNAL OF MEDICAL RESEARCH
- Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance
- (2015) Elizabeth Rendina-Ruedy et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Early Initiation of Endochondral Ossification of Mouse Femur Cultured in Hydrogel with Different Mechanical Stiffness
- (2015) Gulsan Ara Sathi et al. TISSUE ENGINEERING PART C-METHODS
- Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
- (2015) Rinaldo Florencio-Silva et al. Biomed Research International
- Methods for Culturing Human Femur Tissue Explants to Study Breast Cancer Cell Colonization of the Metastatic Niche
- (2015) Zachary S. Templeton et al. Jove-Journal of Visualized Experiments
- The Effects of 1α, 25-dihydroxyvitamin D3 and Transforming Growth Factor-β3 on Bone Development in an Ex Vivo Organotypic Culture System of Embryonic Chick Femora
- (2015) Emma L. Smith et al. PLoS One
- Evaluation of the anti-osteoporotic effects of metformin and sitagliptin in postmenopausal diabetic women
- (2014) Sahar Kamal Hegazy JOURNAL OF BONE AND MINERAL METABOLISM
- Co-cultures of programmable cells of monocytic origin and mesenchymal stem cells do increase osteogenic differentiation
- (2014) Christina Zachos et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Effects of substrate stiffness on adipogenic and osteogenic differentiation of human mesenchymal stem cells
- (2014) Wen Zhao et al. Materials Science & Engineering C-Materials for Biological Applications
- The bone marrow niche for haematopoietic stem cells
- (2014) Sean J. Morrison et al. NATURE
- Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
- (2014) Jan Henkel et al. Bone Research
- Osteoporotic Fracture Models
- (2014) A. Hamish Simpson et al. Current Osteoporosis Reports
- A review of mouse critical size defect models in weight bearing bones
- (2013) Jonathan S. Harris et al. BONE
- Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
- (2013) S U Lauvrak et al. BRITISH JOURNAL OF CANCER
- A systematic review on the critical size defect model
- (2013) André Vajgel et al. CLINICAL ORAL IMPLANTS RESEARCH
- Epigenetic drug 5-azacytidine impairs proliferation of rat limb buds in an organotypic model-system in vitro
- (2013) Vedrana Mužić et al. CROATIAN MEDICAL JOURNAL
- A Novel Ex vivo Culture Model for Inflammatory Bone Destruction
- (2013) A.J. Sloan et al. JOURNAL OF DENTAL RESEARCH
- Prolonged Bioluminescence Monitoring in Mouse Ex Vivo Bone Culture Revealed Persistent Circadian Rhythms in Articular Cartilages and Growth Plates
- (2013) Naoki Okubo et al. PLoS One
- Apparent elastic modulus of ex vivo trabecular bovine bone increases with dynamic loading
- (2013) Juan Vivanco et al. PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
- Mild Heat Stress Enhances Angiogenesis in a Co-culture System Consisting of Primary Human Osteoblasts and Outgrowth Endothelial Cells
- (2013) Ming Li et al. TISSUE ENGINEERING PART C-METHODS
- Anti-diabetic treatment regulates pro-fibrotic TGF-β serum levels in type 2 diabetics
- (2013) Stefan Pscherer et al. Diabetology & Metabolic Syndrome
- SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
- (2013) Eunjeong Seo et al. Cell Reports
- The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
- (2013) Sarah A. Alfaqeeh et al. Jove-Journal of Visualized Experiments
- Calcium phosphate phases integrated in silica/collagen nanocomposite xerogels enhance the bioactivity and ultimately manipulate the osteoblast/osteoclast ratio in a human co-culture model
- (2012) S. Heinemann et al. Acta Biomaterialia
- Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database
- (2012) Rohini K Hernandez et al. Acta Orthopaedica
- Control of osteogenesis by the canonical Wnt and BMP pathways in vivo
- (2012) Sylvain Marcellini et al. BIOESSAYS
- The use of animal models in diabetes research
- (2012) Aileen JF King BRITISH JOURNAL OF PHARMACOLOGY
- Osteoclast Fusion and Fission
- (2012) Ineke D. C. Jansen et al. CALCIFIED TISSUE INTERNATIONAL
- Hyperinsulinemia reduces osteoblast activity in vitro via upregulation of TGF-β
- (2012) Thomas Freude et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Endothelial cells stimulate osteogenic differentiation of mesenchymal stem cells on calcium phosphate scaffolds
- (2012) Ulrike Bulnheim et al. Journal of Tissue Engineering and Regenerative Medicine
- Bone, sweet bone—osteoporotic fractures in diabetes mellitus
- (2012) Christine Hamann et al. Nature Reviews Endocrinology
- Co-culture systems for vascularization — Learning from nature
- (2011) C. James Kirkpatrick et al. ADVANCED DRUG DELIVERY REVIEWS
- Tetrazolium salt based methods for high-throughput evaluation of anti-parasite chemotherapy
- (2011) Cristina Henriques et al. Analytical Methods
- Assessing mitochondrial dysfunction in cells
- (2011) Martin D. Brand et al. BIOCHEMICAL JOURNAL
- Three-dimensional cancer-bone metastasis model using ex-vivo co-cultures of live calvarial bones and cancer cells
- (2011) Paul Curtin et al. BIOMATERIALS
- SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC
- (2011) S B Park et al. CELL DEATH AND DIFFERENTIATION
- Outcomes of Ankle Fractures in Patients with Uncomplicated versus Complicated Diabetes
- (2011) Dane K. Wukich et al. FOOT & ANKLE INTERNATIONAL
- Molecular modulation of osteocalcin and its relevance in diabetes (Review)
- (2011) Jos� Mu�oz-Valle INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Over-expression of Sox2 in C3H10T1/2 cells inhibits osteoblast differentiation through Wnt and MAPK signalling pathways
- (2011) Daofang Ding et al. INTERNATIONAL ORTHOPAEDICS
- Trabecular Quality and Cellular Characteristics of Normal, Diabetic, and Charcot Bone
- (2011) Javier La Fontaine et al. Journal of Foot & Ankle Surgery
- Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level
- (2011) Y.-C. Hwang et al. OSTEOPOROSIS INTERNATIONAL
- Prominent Bone Loss Mediated by RANKL and IL-17 Produced by CD4+ T Cells in TallyHo/JngJ Mice
- (2011) Hee Yeon Won et al. PLoS One
- Review: The Diabetic Bone: A Cellular and Molecular Perspective
- (2011) Robert Blakytny et al. International Journal of Lower Extremity Wounds
- "Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking
- (2010) F. Lassailly et al. BLOOD
- The effect of diabetes mellitus on osseous healing
- (2010) M. Retzepi et al. CLINICAL ORAL IMPLANTS RESEARCH
- Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling?
- (2010) Simon C.F. Rawlinson et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Advances in the Establishment of Defined Mouse Models for the Study of Fracture Healing and Bone Regeneration
- (2010) J H Holstein et al. JOURNAL OF ORTHOPAEDIC TRAUMA
- Rapid vascularization of starch-poly(caprolactone) in vivo by outgrowth endothelial cells in co-culture with primary osteoblasts
- (2010) Shahram Ghanaati et al. Journal of Tissue Engineering and Regenerative Medicine
- Rodent models in bone-related research: the relevance of calvarial defects in the assessment of bone regeneration strategies
- (2010) P S Gomes et al. LABORATORY ANIMALS
- In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract
- (2010) Irina Arnaoutova et al. Nature Protocols
- The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages
- (2010) Marc Daigneault et al. PLoS One
- TGF-β1 As Possible Link between Loss of Bone Mineral Density and Chronic Inflammation
- (2010) Sabrina Ehnert et al. PLoS One
- The Early Fracture Hematoma and Its Potential Role in Fracture Healing
- (2010) Paula Kolar et al. TISSUE ENGINEERING PART B-REVIEWS
- An Ex Vivo Rodent Mandible Culture Model for Bone Repair
- (2010) Emma L. Smith et al. TISSUE ENGINEERING PART C-METHODS
- Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds
- (2010) Ciara M. Murphy et al. Cell Adhesion & Migration
- Bone and Wound Healing in the Diabetic Patient
- (2010) Siddhant K. Mehta et al. Foot and Ankle Clinics
- Characterization of an Ex vivo Femoral Head Model Assessed by Markers of Bone and Cartilage Turnover
- (2010) Suzi Hoegh Madsen et al. Cartilage
- Biophysical Characterization of Styryl Dye-Membrane Interactions
- (2009) Yao Wu et al. BIOPHYSICAL JOURNAL
- Effect of GLP-1 Treatment on Bone Turnover in Normal, Type 2 Diabetic, and Insulin-Resistant States
- (2009) Bernardo Nuche-Berenguer et al. CALCIFIED TISSUE INTERNATIONAL
- Early Complications Following the Operative Treatment of Pilon Fractures with and without Diabetes
- (2009) Alex J. Kline et al. FOOT & ANKLE INTERNATIONAL
- Cyanine-loaded lipid nanoparticles for improved in vivo fluorescence imaging
- (2009) Isabelle Texier et al. JOURNAL OF BIOMEDICAL OPTICS
- Osteoblast and Osteoclast Differentiation in an In Vitro Three-Dimensional Model of Bone
- (2009) Federico Tortelli et al. TISSUE ENGINEERING PART A
- Biomimetic chitosan–nanohydroxyapatite composite scaffolds for bone tissue engineering
- (2008) W.W. Thein-Han et al. Acta Biomaterialia
- Bridging the regeneration gap: Stem cells, biomaterials and clinical translation in bone tissue engineering
- (2008) Jonathan I. Dawson et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds
- (2008) Alexander Hofmann et al. BIOMATERIALS
- Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds
- (2008) Sabine Fuchs et al. BIOMATERIALS
- Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis
- (2008) Yuki Kawashima et al. BONE
- TGFβ3and loading increases osteocyte survival in human cancellous bone culturedex vivo
- (2008) Angharad E. Simpson et al. CELL BIOCHEMISTRY AND FUNCTION
- Osteogenic Protein-1 Overcomes Inhibition of Fracture Healing in the Diabetic Rat: A Pilot Study
- (2008) Louis S. Kidder et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Cocultures of osteoblasts and osteoclasts are influenced by local application of zoledronic acid incorporated in a poly(D,L-lactide) implant coating
- (2008) S. Greiner et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Surgical aspects of the diabetic foot
- (2008) A. H. N. Robinson et al. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
- Ex Vivo Bone Formation in Bovine Trabecular Bone Cultured in a Dynamic 3D Bioreactor Is Enhanced by Compressive Mechanical Strain
- (2008) Valentin David et al. TISSUE ENGINEERING PART A
- Human tooth culture: A study model for reparative dentinogenesis and direct pulp capping materials biocompatibility
- (2007) Odile Téclès et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started