Genomic risk scores for juvenile idiopathic arthritis and its subtypes

Evaluating and improving heritability models using summary statistics

(2020) Doug Speed et al.   NATURE GENETICS

Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

(2019) Seth A. Sharp et al.   DIABETES CARE

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

(2019) Parysatis Sachs et al.   Nature Communications

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Medical pathways of children with juvenile idiopathic arthritis before referral to pediatric rheumatology centers

(2019) Caroline Freychet et al.   JOINT BONE SPINE

Testing population-based performance measures identifies gaps in juvenile idiopathic arthritis (JIA) care

(2019) Claire E.H. Barber et al.   BMC HEALTH SERVICES RESEARCH

Towards clinical utility of polygenic risk scores

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Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

(2018) Michael Inouye et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest

(2017) D J Pappas et al.   PHARMACOGENOMICS JOURNAL

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

(2016) A Hinks et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

(2016) Michael J Ombrello et al.   ANNALS OF THE RHEUMATIC DISEASES

Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility

(2016) Terri H. Finkel et al.   BMC Medical Genetics

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study

(2016) Flora McErlane et al.   RHEUMATOLOGY

Genomic risk prediction of complex human disease and its clinical application

(2015) Gad Abraham et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis

(2015) Justine A. Ellis et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

(2015) Yun R Li et al.   NATURE MEDICINE

Management of juvenile idiopathic arthritis: hitting the target

(2015) Claas Hinze et al.   Nature Reviews Rheumatology

HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

(2015) Michael J. Ombrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic sharing and heritability of paediatric age of onset autoimmune diseases

(2015) Yun R. Li et al.   Nature Communications

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort

(2014) Jaime Guzman et al.   ANNALS OF THE RHEUMATIC DISEASES

Early predictors of prognosis in juvenile idiopathic arthritis: a systematic literature review

(2014) E H Pieter van Dijkhuizen et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases

(2014) J Cobb et al.   PHARMACOGENOMICS JOURNAL

Fast Principal Component Analysis of Large-Scale Genome-Wide Data

(2014) Gad Abraham et al.   PLoS One

Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning

(2014) Gad Abraham et al.   PLoS Genetics

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

(2013) Anne Hinks et al.   NATURE GENETICS

HIBAG—HLA genotype imputation with attribute bagging

(2013) X Zheng et al.   PHARMACOGENOMICS JOURNAL

SparSNP: Fast and memory-efficient analysis of all SNPs for phenotype prediction

(2012) Gad Abraham et al.   BMC BIOINFORMATICS

Performance and Robustness of Penalized and Unpenalized Methods for Genetic Prediction of Complex Human Disease

(2012) Gad Abraham et al.   GENETIC EPIDEMIOLOGY

CLARITY – ChiLdhood Arthritis Risk factor Identification sTudY

(2012) Justine A Ellis et al.   Pediatric Rheumatology

Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis

(2011) Carol A. Wallace et al.   ARTHRITIS AND RHEUMATISM

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Policy challenges for the pediatric rheumatology workforce: Part III. the international situation

(2011) Michael Henrickson   Pediatric Rheumatology

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Quantification of the familial contribution to juvenile idiopathic arthritis

(2010) Sampath Prahalad et al.   ARTHRITIS AND RHEUMATISM

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype

(2010) Halima Moncrieffe et al.   Pharmacogenetics and Genomics

The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling

(2010) Naomi R. Wray et al.   PLoS Genetics

Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis

(2009) H. M. Albers et al.   ARTHRITIS AND RHEUMATISM

Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study

(2008) N. Adib et al.   RHEUMATOLOGY