A role for the MEGF6 gene in predisposition to osteoporosis

Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment

(2020) Nicole Lindsay-Mosher et al.   PLoS Genetics

Joint Association Analysis Identified 18 New Loci for Bone Mineral Density

(2019) Yu-Fang Pei et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The genetic architecture of osteoporosis and fracture risk

(2019) Katerina Trajanoska et al.   BONE

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

(2019) Zhipeng Ma et al.   NATURE

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Model systems for regeneration: zebrafish

(2019) Ines J. Marques et al.   DEVELOPMENT

Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish

(2019) Kazuyuki Hoshijima et al.   DEVELOPMENTAL CELL

MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer Metastasis

(2018) Hanqing Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Generation and characterization of Megf6 null and Cre knock-in alleles

(2018) Ye Wang et al.   GENESIS

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

(2017) Roberta Gioia et al.   HUMAN MOLECULAR GENETICS

Precise Editing of the Zebrafish Genome Made Simple and Efficient

(2016) Kazuyuki Hoshijima et al.   DEVELOPMENTAL CELL

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Database Resources of the National Center for Biotechnology Information

(2016)   NUCLEIC ACIDS RESEARCH

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Genetics of osteoporosis: searching for candidate genes for bone fragility

(2016) Manuela G. M. Rocha-Braz et al.   Archives of Endocrinology Metabolism

An integrative approach to predicting the functional effects of non-coding and coding sequence variation

(2015) Hashem A. Shihab et al.   BIOINFORMATICS

Extracellular matrix networks in bone remodeling

(2015) Andrea I. Alford et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives

(2014) Alexandre Bureau et al.   BIOINFORMATICS

TGF-  mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

(2014) C. Munjal et al.   Disease Models & Mechanisms

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

MutationTaster2: mutation prediction for the deep-sequencing age

(2014) Jana Marie Schwarz et al.   NATURE METHODS

Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders

(2013) Carmen García-Ibarbia et al.   GENE

dbNSFP v2.0: A Database of Human Non-synonymous SNVs and Their Functional Predictions and Annotations

(2013) Xiaoming Liu et al.   HUMAN MUTATION

The zebrafish as a model for complex tissue regeneration

(2013) Matthew Gemberling et al.   TRENDS IN GENETICS

Attenuated BMP1 Function Compromises Osteogenesis, Leading to Bone Fragility in Humans and Zebrafish

(2012) P.V. Asharani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Macrophage-stimulating protein and calcium homeostasis in zebrafish

(2012) Leonie F. A. Huitema et al.   FASEB JOURNAL

Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models

(2012) Hashem A. Shihab et al.   HUMAN MUTATION

Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women

(2012) Tai-Huang Chao et al.   Journal of the Chinese Medical Association

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome

(2012) Timothy J. Dahlem et al.   PLoS Genetics

Maximum-likelihood estimation of recent shared ancestry (ERSA)

(2011) C. D. Huff et al.   GENOME RESEARCH

EGFL6 Promotes Endothelial Cell Migration and Angiogenesis through the Activation of Extracellular Signal-regulated Kinase

(2011) Shek Man Chim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design Considerations for Massively Parallel Sequencing Studies of Complex Human Disease

(2011) Bing-Jian Feng et al.   PLoS One

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

(2011) Graciana Diez-Roux et al.   PLOS BIOLOGY

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++

(2010) Eugene V. Davydov et al.   PLoS Computational Biology

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

I-TASSER: Fully automated protein structure prediction in CASP8

(2009) Yang Zhang   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

A genome-wide linkage scan for low spinal bone mineral density in a single extended family confirms linkage to 1p36.3

(2008) Andy Willaert et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Multiple Genetic Loci for Bone Mineral Density and Fractures

(2008) Unnur Styrkarsdottir et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

(2008) M. J. Jurynec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A reference standard for the description of osteoporosis

(2007) John A. Kanis et al.   BONE