Article
Medicine, Research & Experimental
Qing Wu, Jongyun Jung
Summary: This study introduces a novel genome-wide polygenic score (GPS) to quantify inherited susceptibility to osteoporosis and osteoporotic fracture, providing new opportunities for clinical prevention and risk assessment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Haidong Wei, Yanju Bi, Yulai Wang, Qian Zhao, Runxiang Zhang, Jianhong Li, Jun Bao
Summary: Keel bone fractures in laying hens can affect the welfare, health, and production performance of the hens. Through a study of 120 Hy-line Brown laying hens, it was found that abnormal bone metabolism is associated with keel bone fractures, highlighting the importance of bone health in laying hens.
Article
Endocrinology & Metabolism
Jose L. Ramirez-GarciaLuna, Karla Rangel-Berridi, Ore-Oluwa Olasubulumi, Derek H. Rosenzweig, Janet E. Henderson, Rahul Gawri, Paul A. Martineau
Summary: This study investigated how immune cells influence bone repair using a mouse model. The results showed that mice exposed to subsequent fractures had significantly improved bone morphometric parameters and increased content of blood vessels, osteoclasts, and macrophages. These findings suggest that a transient increase in the inflammatory state during healing injury promotes faster bone remodelling and enhanced neo-angiogenesis.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Gengqi Wang, Wenqiang Xu, Junjie Zhang, Tian Tang, Jing Chen, Changchun Fan
Summary: The study aims to address the challenge of repairing fractures in the presence of infection using nanotechnology. By producing iron oxide nanoparticles containing hydroxyapatite and Raloxifene, targeted drug delivery, infection control, and promotion of cell proliferation/differentiation are achieved for tissue repair. The results demonstrate the potential of R-IONPs-HA in repairing bone fractures and preventing infection through its good biocompatibility, antibacterial activity, and ossification induction.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Review
Immunology
Tatjana Bordukalo-Niksic, Vera Kufner, Slobodan Vukicevic
Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Boyang Wan, Nobuhiro Yoda, Keke Zheng, Zhongpu Zhang, Chi Wu, Jonathan Clark, Keiichi Sasaki, Michael Swain, Qing Li
Summary: The study developed a numerical approach to predict the fatigue life of reconstruction plates considering the effect of bone remodeling. The simulation results indicated that appropriate remodeling of grafted bone could positively extend the fatigue life of fixation plates.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Endocrinology & Metabolism
Ariane Zamarioli, Gremah Adam, Kevin A. A. Maupin, Paul J. J. Childress, Alexander Brinker, Joao P. B. Ximenez, Nabarun Chakraborty, Aarti Gautam, Rasha Hammamieh, Melissa A. A. Kacena
Summary: The study found that administering BMP2 at the fracture site of mice had systemic effects on distant bones and the mechanisms of action may differ between Earth and spaceflight.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Miao Tian, Ying-bo Han, Gui-yun Yang, Jin-long Li, Chang-sai Shi, Dan Tian
Summary: Lactoferrin (Lf) is a multifunctional protein that plays critical roles in bone remodeling by regulating the function of various cell types involved in the process. It stimulates osteoblast and chondrocyte activity while inhibiting osteoclast function, leading to accelerated fracture repair and improved bone health. These effects have driven the exploration of Lf as a potential therapeutic target for bone-related diseases. However, delivery strategies need to be developed to enhance its bioavailability at the target site. Overall, the importance of Lf in bone remodeling and its potential therapeutic applications warrant a score of 8 out of 10.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Yiru Fu, Jinlin Song
Summary: Low-intensity pulsed ultrasound (LIPUS) can improve orthodontic tooth movement and alveolar bone remodeling by promoting the interaction between osteoblasts and osteoclasts, thus enhancing the effectiveness of orthodontic treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Velimir Matkovic, Prem Goel, Stacey L. Mobley, Nancy E. Badenhop-Stevens, Eun-Jeong Ha, Bin Li, Mario Skugor, Albert Clairmont
Summary: The aim of this study was to compare the relationship between bone mineral density and fractures in young children and adolescents. The results of a case-control study showed that adolescents with fractures had reduced bone mineral density at multiple skeletal regions, while this was not the case with younger children. These findings have implications for the prevention of bone fragility in the pediatric population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yongquan Gao, Xiaochen Liu, Yuan Gu, Deye Song, Muliang Ding, Lele Liao, Junjie Wang, Jiangdong Ni, Guangxu He
Summary: Bisphosphonates do not significantly affect fracture healing time in fracture patients, but they do increase bone density, prevent osteoporosis, and inhibit both bone resorption and formation markers. Early application of bisphosphonates after injury in the appropriate patient population should be considered.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Weizhou Wang, Yanghao Wang, Zhihong Tang, Yongcheng Chen, Zhui Liu, Hao Duan, Zongyu Zhong, Fei He
Summary: MSCs transplantation effectively promoted bone density and trabecular number in ovariectomized mice, as well as enhanced vascular repair and prevented osteoporosis development in mice with femoral artery ligation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Anthony L. Guerrerio, Allyson Mateja, Marjohn Rasooly, Samara Levin, Alaina Magnani, Caeden Dempsey, Gretchen MacCarrick, Harry C. Dietz, Erica Brittain, Alison M. Boyce, Pamela A. Frischmeyer-Guerrerio
Summary: Loeys-Dietz syndrome (LDS) patients commonly have reduced bone density and increased risk of fractures, possibly due to increased bone resorption. Certain clinical features can predict a subgroup of patients at highest risk of low bone density and fractures.
GENETICS IN MEDICINE
(2022)
Article
Orthopedics
Armaun J. Emami, Aimy Sebastian, Yu-Yang Lin, Cristal S. Yee, Benjamin Osipov, Gabriela G. Loots, Tamara Alliston, Blaine A. Christiansen
Summary: This study investigated the alterations in lacunar-canalicular microstructure and perilacunar/canalicular remodeling (PLR) rate in the contralateral limb following femoral fracture in mice. The results showed significant changes in canalicular width and downregulation of PLR-associated genes post-fracture, indicating potential impacts on bone mechanical properties. These findings enhance our understanding of the systemic effects of fracture on distant skeletal sites and increased fracture risk.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yiran Zheng, Luisa Sophie Rajcsanyi, Manuela Kowalczyk, Johanna Giuranna, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Foecker, Saad Al-Lahham, Johannes Hebebrand, Dagmar Fuhrer, Susanne Tan, Denise Zwanziger, Triinu Peters, Anke Hinney
Summary: The bone-derived adipokine lipocalin-2 is involved in body weight regulation and its levels are influenced by variants in the LCN2 gene. Variants in LCN2 and MC4R genes have an impact on the circulating levels of lipocalin-2. These findings suggest the important roles of LCN2 variants in the regulation of lipocalin-2 levels and body weight.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
T. C. Ribeiro, A. A. Jorge, L. R. Montenegro, M. Q. Almeida, B. Ferraz-de-Souza, M. Y. Nishi, B. B. Mendonca, A. C. Latronico
HORMONE AND METABOLIC RESEARCH
(2016)
Article
Multidisciplinary Sciences
Debora Lucia Seguro Danilovic, Bruno Ferraz-de-Souza, Amanda Wictky Fabri, Nathalie Oliveira Santana, Marco Aurelio Kulcsar, Claudio Roberto Cernea, Suemi Marui, Ana Oliveira Hoff
Article
Endocrinology & Metabolism
Sergio Setsuo Maeda, Carolina Aguiar Moreira, Victoria Zeghbi Cochenski Borba, Francisco Bandeira, Maria Lucia Fleiuss de Farias, Joao Lindolfo Cunha Borges, Francisco Jose Albuquerque de Paula, Felipe Augusto Brasileiro Vanderlei, Fabio Luiz de Menezes Montenegro, Rodrigo Oliveira Santos, Bruno Ferraz-de-Souza, Marise Lazaretti-Castro
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2018)
Editorial Material
Endocrinology & Metabolism
Bruno Ferraz-de-Souza
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2018)
Article
Cell Biology
Pedro L. F. Costa, Monica M. Franca, Maria L. Katayama, Eduardo T. Carneiro, Regina M. Martin, Maria A. K. Folgueira, Ana C. Latronico, Bruno Ferraz-de-Souza
Article
Endocrinology & Metabolism
L. L. Iervolino, B. Ferraz-de-Souza, R. M. Martin, F. C. Costa, M. C. Miranda, B. B. Mendonca, T. S. Bachega
OSTEOPOROSIS INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
A. M. Fernandes, M. G. M. Rocha-Braz, M. M. Franca, A. M. Lerario, V. R. F. Simoes, E. A. Zanardo, L. D. Kulikowski, R. M. Martin, B. B. Mendonca, B. Ferraz-de-Souza
OSTEOPOROSIS INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Marcelo Belli, Regina Matsunaga Martin, Marilia D'Elboux Guimaraes Brescia, Climerio Pereira Nascimento, Ledo Mazzei Massoni Neto, Sergio Samir Arap, Bruno Ferraz-de-Souza, Rosa Maria Affonso Moyses, Munro Peacock, Fabio Luiz de Menezes Montenegro
Article
Endocrinology & Metabolism
Manuela G. M. Rocha-Braz, Monica M. Franca, Adriana M. Fernandes, Antonio M. Lerario, Evelin A. Zanardo, Lucas S. de Santana, Leslie D. Kulikowski, Regina M. Martin, Berenice B. Mendonca, Bruno Ferraz-de-Souza
Summary: In a study on the genetic bases of osteoporosis, 28 cases were analyzed with targeted sequencing, revealing only 3 pathogenic or likely pathogenic variants. 21% of cases showed associations of variants in different genes, suggesting challenges in identifying actionable pathogenic variants in intriguing cases of idiopathic or familial osteoporosis.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Endocrinology & Metabolism
Federica Buonocore, Avinaash Maharaj, Younus Qamar, Katrin Koehler, Jenifer P. Suntharalingham, Li F. Chan, Bruno Ferraz-de-Souza, Claire R. Hughes, Lin Lin, Rathi Prasad, Jeremy Allgrove, Edward T. Andrews, Charles R. Buchanan, Tim D. Cheetham, Elizabeth C. Crowne, Justin H. Davies, John W. Gregory, Peter C. Hindmarsh, Tony Hulse, Nils P. Krone, Pratik Shah, M. Guftar Shaikh, Catherine Roberts, Peter E. Clayton, Mehul T. Dattani, N. Simon Thomas, Angela Huebner, Adrian J. Clark, Louise A. Metherell, John C. Achermann
Summary: Genetic causes of primary adrenal insufficiency in children and young people were investigated in a cohort of 155 individuals in the UK, with 66.5% receiving a genetic diagnosis. Pathogenic variants were identified in 11 genes, highlighting the importance of genetic testing in defining the cause of PAI. Age at presentation, treatment, ancestral background, and birth weight can provide diagnostic clues, but genetic testing is often necessary for accurate diagnosis.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Endocrinology & Metabolism
Miguel Madeira, Andre Caroli Rocha, Carolina Aguiar Moreira, Aguida Maria Menezes Aguiar, Sergio Setsuo Maeda, Abel Silveira Cardoso, Charlles Heldan de Moura Castro, Catarina Brasil D'Alva, Barbara Campolina Carvalho Silva, Bruno Ferraz-de-Souza, Marise Lazaretti-Castro, Francisco Bandeira, Sandra R. Torres
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2020)
Review
Developmental Biology
Sorahia Domenice, Aline Zamboni Machado, Frederico Moraes Ferreira, Bruno Ferraz-de-Souza, Antonio Marcondes Lerario, Lin Lin, Mirian Yumie Nishi, Nathalia Lisboa Gomes, Thatiana Evelin da Silva, Rosana Barbosa Silva, Rafaela Vieira Correa, Luciana Ribeiro Montenegro, Amanda Narciso, Elaine Maria Frade Costa, John C. Achermann, Berenice Bilharinho Mendonca
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
(2016)