Autophagy‐Sirt3 axis decelerates hematopoietic aging

Deterioration of hematopoietic autophagy is linked to osteoporosis

(2020) Ye Yuan et al.   AGING CELL

Aging-induced IL27Ra Signaling Impairs Hematopoietic Stem Cells

(2020) Hanqing He et al.   BLOOD

MitophAging: Mitophagy in Aging and Disease

(2020) Daniela Bakula et al.   Frontiers in Cell and Developmental Biology

Nucleophagy: from homeostasis to disease

(2019) Margarita-Elena Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Blood autophagy defect causes accelerated non-hematopoietic organ aging

(2019) Yixuan Fang et al.   Aging-US

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

(2019) Xingrun Zhang et al.   Cell Discovery

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

(2019) Hao Meng et al.   Frontiers in Aging Neuroscience

Post-translational Modifications of Key Machinery in the Control of Mitophagy

(2019) Liming Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence

(2018) Mary Mohrin et al.   AGING CELL

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment

(2018) Ryo Yamamoto et al.   Cell Stem Cell

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Aging alters the epigenetic asymmetry of HSC division

(2018) M. Carolina Florian et al.   PLOS BIOLOGY

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

DNA damage tolerance in hematopoietic stem and progenitor cells in mice

(2017) Bas Pilzecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging

(2017) Sarah E. Latchney et al.   SEMINARS IN HEMATOLOGY

Molecular mechanisms underlying lineage bias in aging hematopoiesis

(2017) Harold K. Elias et al.   SEMINARS IN HEMATOLOGY

Age-associated changes in human hematopoietic stem cells

(2017) Wendy W. Pang et al.   SEMINARS IN HEMATOLOGY

Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm

(2016) Majing Luo et al.   Autophagy

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

(2016) Hu Wang et al.   Cell Stem Cell

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells

(2016) Shailaja Akunuru et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells

(2016) Yixuan Fang et al.   Oncotarget

Autophagy is required for stem cell mobilization by G-CSF

(2015) L. Leveque-El Mouttie et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

(2015) Peter D. Adams et al.   Cell Stem Cell

Hierarchal Autophagic Divergence of Hematopoietic System

(2015) Yan Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Autophagy Sustains Hematopoiesis Through Targeting Notch

(2015) Yan Cao et al.   STEM CELLS AND DEVELOPMENT

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

(2014) Pauline Rimmelé et al.   Stem Cell Reports

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Telomere Dynamics in Mice and Humans

(2013) Rodrigo T. Calado et al.   SEMINARS IN HEMATOLOGY

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

A novel method for autophagy detection in primary cells

(2012) Kanchan Phadwal et al.   Autophagy

Restoring Cell Polarity: An HSC Fountain of Youth

(2012) Carmen Carrillo-García et al.   Cell Stem Cell

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

(2010) F. Liu et al.   BLOOD

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE