Deterioration of hematopoietic autophagy is linked to osteoporosis

Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis

(2019) Jiadong Wu et al.   BONE

VEGFA from Early Osteoblast Lineage Cells (Osterix+) is Required in Mice for Fracture Healing

(2019) Evan G. Buettmann et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Iron Accumulation Leads to Bone Loss by Inducing Mesenchymal Stem Cell Apoptosis Through the Activation of Caspase3

(2018) Ye Yuan et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Bone and blood interactions in human health and disease

(2018) Rodrigo J. Valderrábano et al.   BONE

Osteocyte regulation of bone and blood

(2018) Paola Divieti Pajevic et al.   BONE

Annexin A5 involvement in bone overgrowth at the enthesis

(2018) Akemi Shimada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone disease in β thalassemia patients: past, present and future perspectives

(2018) Vincenzo De Sanctis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Loss of the Hematopoietic Stem Cell Factor GATA2 in the Osteogenic Lineage Impairs Trabecularization and Mechanical Strength of Bone

(2018) Alexander Tolkachov et al.   MOLECULAR AND CELLULAR BIOLOGY

Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis

(2018) Marta B. Alvarez et al.   STEM CELLS AND DEVELOPMENT

Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice

(2018) Jie Huang et al.   Theranostics

Osteogenesis and aging: lessons from mesenchymal stem cells

(2018) Arantza Infante et al.   Stem Cell Research & Therapy

BMI-1 Mediates Estrogen-Deficiency-Induced Bone Loss by Inhibiting Reactive Oxygen Species Accumulation and T Cell Activation

(2017) Jinbo Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Human type H vessels are a sensitive biomarker of bone mass

(2017) Liang Wang et al.   Cell Death & Disease

Vascular endothelial growth factor control mechanisms in skeletal growth and repair

(2016) Kai Hu et al.   DEVELOPMENTAL DYNAMICS

Bone Density Loss Is Associated With Blood Cell Counts

(2016) Rodrigo J Valderrábano et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+Hematopoietic Stem-Progenitor Cells

(2016) Maria Catalina Gomez-Puerto et al.   STEM CELLS

Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage

(2016) Marilina Piemontese et al.   Scientific Reports

Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton

(2016) Rui Yue et al.   eLife

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

(2015) M. Bowers et al.   BLOOD

Bone marrow ablation demonstrates that estrogen plays an important role in osteogenesis and bone turnover via an antioxidative mechanism

(2015) Chunmin Shi et al.   BONE

Autophagy regulates the cell cycle of murine HSPCs in a nutrient-dependent manner

(2015) Yan Cao et al.   EXPERIMENTAL HEMATOLOGY

Hierarchal autophagic divergence of hematopoietic system.

(2015) Yan Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis

(2015) Linda Vi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased Incidence of Fractures in Recipients of Hematopoietic Stem-Cell Transplantation

(2015) Xerxes N. Pundole et al.   JOURNAL OF CLINICAL ONCOLOGY

Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass

(2015) Wang Xiao et al.   JOURNAL OF ENDOCRINOLOGY

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

(2015) Fatemeh Atashi et al.   STEM CELLS AND DEVELOPMENT

Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway—Implications for the treatment of osteoporosis

(2014) Yue-Hua Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

(2013) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoporosis after Stem Cell Transplantation

(2013) Brian L. McClune et al.   Current Osteoporosis Reports

A novel method for autophagy detection in primary cells

(2012) Kanchan Phadwal et al.   Autophagy

Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

(2012) Beom-Jun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

(2012) Anna Mansour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Hematopoietic Cell Regulation of Osteoblast Proliferation and Differentiation

(2011) Monique Bethel et al.   Current Osteoporosis Reports

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells

(2009) R. T. Calado et al.   BLOOD

Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche

(2009) Jennifer M. Gillette et al.   NATURE CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Hematopoietic Stem Cells Regulate Mesenchymal Stromal Cell Induction into Osteoblasts Thereby Participating in the Formation of the Stem Cell Niche

(2008) Younghun Jung et al.   STEM CELLS