Parallels between retinal and brain pathology and response to immunotherapy in old, late‐stage Alzheimer's disease mouse models

Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

(2020) Haoshen Shi et al.   ACTA NEUROPATHOLOGICA

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

(2020) John V. Pluvinage et al.   NATURE REVIEWS NEUROSCIENCE

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

(2020) Rieke Martens et al.   Nature Communications

Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses

(2020) Songlin Li et al.   Frontiers in Immunology

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals

(2020) Reisa A. Sperling et al.   JAMA Neurology

Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus

(2020) Lily Y.-L. Chang et al.   Frontiers in Neuroscience

In vivo Retinal Fluorescence Imaging With Curcumin in an Alzheimer Mouse Model

(2020) Ahmad Sidiqi et al.   Frontiers in Neuroscience

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Functional and morphological changes of the retinal vessels in Alzheimer’s disease and mild cognitive impairment

(2019) Giuseppe Querques et al.   Scientific Reports

Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice

(2019) Hyeonwi Son et al.   Scientific Reports

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

(2019) Neta Rosenzweig et al.   Nature Communications

Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer’s Disease and Vascular Brain Injury

(2019) Charles DeCarli et al.   JOURNAL OF ALZHEIMERS DISEASE

What is the "Relevant" Amyloid β 42 Concentration?

(2019) Jevgenij Raskatov   CHEMBIOCHEM

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer’s disease

(2019) Philippe Bourassa et al.   ACTA NEUROPATHOLOGICA

The vascular side of Alzheimer's disease

(2019) Arthur Liesz   SCIENCE

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

(2019) Khanh V. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

(2019) Xavier Hadoux et al.   Nature Communications

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

(2019) Maya Koronyo-Hamaoui et al.   BRAIN

Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals

(2019) Nina Schultz et al.   JOURNAL OF ALZHEIMERS DISEASE

Capillary cerebral amyloid angiopathy in Alzheimer’s disease: association with allocortical/hippocampal microinfarcts and cognitive decline

(2018) Moritz Hecht et al.   ACTA NEUROPATHOLOGICA

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

(2018) Nina Schultz et al.   AGING CELL

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models

(2018) Altan Rentsendorj et al.   BRAIN BEHAVIOR AND IMMUNITY

Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction

(2018) Shuxuan Huang et al.   BRAIN RESEARCH

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

(2018) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer’s Disease

(2018) Katerina A. Tetzloff et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer’s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery

(2018) Antonietta Vilella et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease

(2018) Rowan Gurney et al.   NEUROPATHOLOGY

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease

(2018) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

(2018) Alfonso Grimaldi et al.   Cell Death & Disease

Left lateralized cerebral glucose metabolism declines in amyloid-β positive persons with mild cognitive impairment

(2018) Christopher M. Weise et al.   NeuroImage-Clinical

Plasma Amyloid-β Levels are Significantly Associated with a Transition Toward Alzheimer's Disease as Measured by Cognitive Decline and Change in Neocortical Amyloid Burden

(2018) Alan Rembach et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings

(2018) Bliss Elizabeth O’Bryhim et al.   JAMA Ophthalmology

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer’s disease retinas

(2018) Jurre den Haan et al.   Acta Neuropathologica Communications

Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis

(2017) Lora Minkova et al.   HUMAN BRAIN MAPPING

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

(2017) Marius Chiasseu et al.   Molecular Neurodegeneration

Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology

(2017) Douglas G. Walker et al.   NEUROBIOLOGY OF AGING

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Amelioration of amyloid β-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-κB signaling and NLRP3 inflammasome

(2017) Chunyan Lei et al.   NEUROSCIENCE

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

(2017) Jay Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases

(2017) Jonah Doustar et al.   Frontiers in Neurology

Ocular indicators of Alzheimer’s: exploring disease in the retina

(2016) Nadav J. Hart et al.   ACTA NEUROPATHOLOGICA

Visual system manifestations of Alzheimer's disease

(2016) Yael Kusne et al.   ACTA OPHTHALMOLOGICA

Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala

(2016) Christian Wachinger et al.   BRAIN

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis

(2016) M.T. Ferretti et al.   BRAIN BEHAVIOR AND IMMUNITY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

(2016) Lana M. Osborn et al.   PROGRESS IN NEUROBIOLOGY

Retinal amyloid peptides and complement factor H in transgenic models of Alzheimerʼs disease

(2016) Peter N. Alexandrov et al.   NEUROREPORT

Melanopsin retinal ganglion cell loss in Alzheimer disease

(2015) Chiara La Morgia et al.   ANNALS OF NEUROLOGY

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin

(2015) Rajni Parthasarathy et al.   EXPERIMENTAL EYE RESEARCH

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes

(2015) Willa D. Brenowitz et al.   NEUROBIOLOGY OF AGING

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer’s Disease

(2015) Carolyn C. Rudy et al.   Aging and Disease

Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

(2014) Kenneth E. Bernstein et al.   BIOLOGICAL CHEMISTRY

Asymmetry and heterogeneity of Alzheimer’s and frontotemporal pathology in primary progressive aphasia

(2014) M.-Marsel Mesulam et al.   BRAIN

Interocular symmetry of retinal nerve fibre layer thickness in healthy eyes: a spectral-domain optical coherence tomographic study

(2014) Young Hoon Hwang et al.   Clinical and Experimental Optometry

ACE Overexpression in Myelomonocytic Cells: Effect on a Mouse Model of Alzheimer’s Disease

(2014) Maya Koronyo-Hamaoui et al.   CURRENT HYPERTENSION REPORTS

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer’s-like cognitive decline

(2014) Kenneth E. Bernstein et al.   JOURNAL OF CLINICAL INVESTIGATION

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

(2013) Manja Lehmann et al.   BRAIN

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice

(2013) Christian Schön et al.   PLoS One

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Distinct laterality alterations distinguish mild cognitive impairment and Alzheimer's disease from healthy aging: Statistical parametric mapping with high resolution MRI

(2012) Xiaojing Long et al.   HUMAN BRAIN MAPPING

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease in the Retina: Imaging Retinal Aß Plaques for Early Diagnosis and Therapy Assessment

(2012) Yosef Koronyo et al.   Neurodegenerative Diseases

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Trafficking CD11b-Positive Blood Cells Deliver Therapeutic Genes to the Brain of Amyloid-Depositing Transgenic Mice

(2010) L. Lebson et al.   JOURNAL OF NEUROSCIENCE

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Down-regulation of glutamine synthetase enhances migration of rat astrocytes after in vitro injury

(2010) Jian Zou et al.   NEUROCHEMISTRY INTERNATIONAL

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

(2009) Bingqian Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9

(2009) Maya Koronyo-Hamaoui et al.   JOURNAL OF NEUROCHEMISTRY

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

(2008) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

(2008) Dietmar Rudolf Thal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE