Ruscogenin attenuates particulate matter-induced acute lung injury in mice via protecting pulmonary endothelial barrier and inhibiting TLR4 signaling pathway

Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway

(2020) Lingjing Liu et al.   Aging-US

Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by suppressing TLR4 signaling

(2020) Yunhao Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibitory functions of maslinic acid on particulate matter-induced lung injury through TLR4-mTOR-autophagy pathways

(2020) So Yeon Jeong et al.   ENVIRONMENTAL RESEARCH

Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells

(2020) Gloria Asensio-Juárez et al.   Cells

Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway

(2019) Yanni Lv et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Fluorescent reconstitution on deposition of PM2.5 in lung and extrapulmonary organs

(2019) Donghai Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary inflammation induced by low dose particulate matter exposure in mice

(2019) Yik Lung Chan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

In Vivo Comparative Study on Acute and Sub-acute Biological Effects Induced by Ultrafine Particles of Different Anthropogenic Sources in BALB/c Mice

(2019) Francesca Farina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic and low-level particulate matter exposure can sustainably mediate lung damage and alter CD4 T cells during acute lung injury

(2019) Yusheng Li et al.   MOLECULAR IMMUNOLOGY

Ambient Particulate Air Pollution and Daily Mortality in 652 Cities

(2019) Cong Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative analysis of mRNAs, miRNAs and lncRNAs in urban particulate matter SRM 1648a-treated EA.hy926 human endothelial cells

(2019) Yan Wang et al.   CHEMOSPHERE

The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM2.5)

(2019) Pengyuan Dai et al.   CHEMOSPHERE

PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation

(2019) Yan-Min Long et al.   JOURNAL OF HAZARDOUS MATERIALS

Fine particulate matter from pig house induced immune response by activating TLR4/MAPK/NF-κB pathway and NLRP3 inflammasome in alveolar macrophages

(2019) Qian Tang et al.   CHEMOSPHERE

Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury

(2018) Yun-he Ding et al.   ACTA PHARMACOLOGICA SINICA

Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways

(2018) Xiaoquan Rao et al.   ANTIOXIDANTS & REDOX SIGNALING

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury

(2018) Weijie Dong et al.   Autophagy

High molecular weight hyaluronan attenuates fine particulate matter-induced acute lung injury through inhibition of ROS-ASK1-p38/JNK-mediated epithelial apoptosis

(2018) Chenming Xu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling

(2018) Jia Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endocytosis of particulate matter induces cytokine production by neutrophil via Toll-like receptor 4

(2018) Tadahiro Miyake et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice

(2018) Chung-I Lin et al.   International Journal of Biological Sciences

Seasonal variation and chemical composition of particulate matter: A study by XPS, ICP-AES and sequential microanalysis using Raman with SEM/EDS

(2018) Lucy T. González et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

The Lancet Commission on pollution and health

(2018) Philip J Landrigan et al.   LANCET

Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma

(2018) John P Reilly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway

(2018) Yuanli Xia et al.   BIOMEDICINE & PHARMACOTHERAPY

Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice

(2018) Yuan Li et al.   PHYTOTHERAPY RESEARCH

Microtubule destabilization caused by particulate matter contributes to lung endothelial barrier dysfunction and inflammation

(2018) Pratap Karki et al.   CELLULAR SIGNALLING

Air Pollution and Noncommunicable Diseases

(2018) Dean E. Schraufnagel et al.   CHEST

Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness

(2018) Mengmeng Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

VCAM-1-mediated neutrophil infiltration exacerbates ambient fine particle-induced lung injury

(2018) Anfeng Cui et al.   TOXICOLOGY LETTERS

Particle deposition in the human lung: Health implications of particulate matter from different sources

(2018) Qihong Deng et al.   ENVIRONMENTAL RESEARCH

Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter

(2017) Hussein Traboulsi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015

(2017) Aaron J Cohen et al.   LANCET

Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation

(2017) Xu-Chen Xu et al.   TOXICOLOGY LETTERS

The Combination of Three Components Derived from Sheng MaiSan Protects Myocardial Ischemic Diseases and Inhibits Oxidative Stress via Modulating MAPKs and JAK2-STAT3 Signaling Pathways Based on Bioinformatics Approach

(2017) Fang Li et al.   Frontiers in Pharmacology

Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway

(2017) Jian Wang et al.   Journal of Thoracic Disease

Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress

(2017) Petra Haberzettl et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcription Factor NF-κB: An Update on Intervention Strategies

(2016) Arvind Panday et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic InflammationNovelty and Significance

(2016) C. Arden Pope et al.   CIRCULATION RESEARCH

The health effects of ambient PM2.5 and potential mechanisms

(2016) Shaolong Feng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations –results from a panel study

(2016) Regina Rückerl et al.   ENVIRONMENTAL RESEARCH

PM 2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways

(2016) Kanae Bekki et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ophiopogon japonicus—A phytochemical, ethnomedicinal and pharmacological review

(2016) Min-Hui Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases

(2015) Fang Li et al.   ACTA PHARMACOLOGICA SINICA

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Ruscogenin suppresses mouse neutrophil activation: Involvement of protein kinase A pathway

(2015) Y.N. Lin et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat

(2014) Hung-Jen Lu et al.   BMC Complementary and Alternative Medicine

Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke

(2013) Teng Guan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats

(2013) Li-Qing Bi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pressurized Liquid Extraction of Diesel and Air Particulate Standard Reference Materials: Effect of Extraction Temperature and Pressure

(2012) Michele M. Schantz et al.   ANALYTICAL CHEMISTRY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways

(2011) Thomas Kampfrath et al.   CIRCULATION RESEARCH

Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB

(2011) Qi Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ruscogenin Mainly Inhibits Nuclear Factor-κB but Not Akt and Mitogen-Activated Protein Kinase Signaling Pathways in Human Umbilical Vein Endothelial Cells

(2010) Jiaxi Song et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter

(2009) Joanna Shoenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL