Macropinocytosis in Different Cell Types: Similarities and Differences

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

(2020) John C. Charpentier et al.   Nature Communications

Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration

(2019) Hélène D. Moreau et al.   DEVELOPMENTAL CELL

FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages

(2019) Wei Hong Toh et al.   JOURNAL OF CELL SCIENCE

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro

(2019) Anjana Ajikumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of novel macropinocytosis inhibitors using a rational screen of FDA-approved drugs

(2018) Hui-Ping Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer

(2018) Gil Redelman-Sidi et al.   CANCER RESEARCH

NGF steers microglia toward a neuroprotective phenotype

(2018) Caterina Rizzi et al.   GLIA

The physiological regulation of macropinocytosis during Dictyostelium growth and development

(2018) Thomas D. Williams et al.   JOURNAL OF CELL SCIENCE

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis

(2018) Dar’ya S. Redka et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

A Novel Method to Image Macropinocytosis in Vivo

(2018) Lunhao Chen et al.   Frontiers in Neuroscience

Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement

(2018) Dan Dou et al.   Frontiers in Immunology

Macropinosome formation by tent pole ruffling in macrophages

(2018) Nicholas D. Condon et al.   JOURNAL OF CELL BIOLOGY

Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance

(2018) Johnathan Canton   Frontiers in Immunology

Function of small GTPases in Dictyostelium macropinocytosis

(2018) Thomas D. Williams et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The breadth of macropinocytosis research

(2018) Joel A. Swanson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes

(2018) Adam A. Wall et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors

(2017) Adam A. Wall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Escherichia coli K1 utilizes host macropinocytic pathways for invasion of brain microvascular endothelial cells

(2017) Lip Nam Loh et al.   TRAFFIC

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

Glucocorticoid-Induced Leucine Zipper Protein Controls Macropinocytosis in Dendritic Cells

(2016) Joseph Calmette et al.   JOURNAL OF IMMUNOLOGY

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

A plasma membrane template for macropinocytic cups

(2016) Douwe M Veltman et al.   eLife

Macropinocytosis Exploitation by Cancers and Cancer Therapeutics

(2016) Kevin D. Ha et al.   Frontiers in Physiology

GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells

(2016) Mobashar Hussain Urf Turabe Fazil et al.   Scientific Reports

High-Content, Full Genome siRNA Screen for Regulators of Oncogenic HRAS-Driven Macropinocytosis

(2015) Myles Fennell et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

The effect of the size of fluorescent dextran on its endocytic pathway

(2015) Lei Li et al.   CELL BIOLOGY INTERNATIONAL

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages

(2015) J. P. Lim et al.   JOURNAL OF CELL SCIENCE

Albumin-associated free fatty acids induce macropinocytosis in podocytes

(2015) Jun-Jae Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

(2015) Rafaa Zeineddine et al.   Molecular Neurodegeneration

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

(2015) Weihao Tang et al.   Molecular Brain

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

(2015) Rafaa Zeineddine et al.   Frontiers in Physiology

Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells

(2015) Zhenzhen Liu et al.   Frontiers in Physiology

Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells

(2014) Yanrong Qian et al.   CANCER LETTERS

Determining the macropinocytic index of cells through a quantitative image-based assay

(2014) Cosimo Commisso et al.   Nature Protocols

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis

(2014) M. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

(2014) Youhei Egami et al.   Frontiers in Physiology

Echovirus 1 Entry into Polarized Caco-2 Cells Depends on Dynamin, Cholesterol, and Cellular Factors Associated with Macropinocytosis

(2013) S. E. Krieger et al.   JOURNAL OF VIROLOGY

Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes

(2013) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macropinocytosis is responsible for the uptake of pathogenic and non-pathogenic mycobacteria by B lymphocytes (Raji cells)

(2012) Blanca Estela García-Pérez et al.   BMC MICROBIOLOGY

Filamentous Influenza Virus Enters Cells via Macropinocytosis

(2012) J. S. Rossman et al.   JOURNAL OF VIROLOGY

Establishment of outgrowth endothelial cells from peripheral blood

(2012) Javier Martin-Ramirez et al.   Nature Protocols

SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages

(2012) J. P. Lim et al.   Biology Open

A growth factor signaling cascade confined to circular ruffles in macrophages

(2012) T. P. Welliver et al.   Biology Open

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Ruffles limit diffusion in the plasma membrane during macropinosome formation

(2011) T. P. Welliver et al.   JOURNAL OF CELL SCIENCE

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Syntaxin 1B Suppresses Macropinocytosis and Semaphorin 3A-Induced Growth Cone Collapse

(2011) H. Kabayama et al.   JOURNAL OF NEUROSCIENCE

Measles Virus Glycoprotein-Pseudotyped Lentiviral Vector-Mediated Gene Transfer into Quiescent Lymphocytes Requires Binding to both SLAM and CD46 Entry Receptors

(2011) C. Frecha et al.   JOURNAL OF VIROLOGY

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

(2011) Nirupama Mulherkar et al.   VIROLOGY

Native Low-Density Lipoprotein Uptake by Macrophage Colony-Stimulating Factor–Differentiated Human Macrophages Is Mediated by Macropinocytosis and Micropinocytosis

(2010) Joshua J. Anzinger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Mature dendritic cells use endocytic receptors to capture and present antigens

(2010) C. D. Platt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry

(2010) J. Mercer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Kaposi's Sarcoma-Associated Herpesvirus Utilizes an Actin Polymerization-Dependent Macropinocytic Pathway To Enter Human Dermal Microvascular Endothelial and Human Umbilical Vein Endothelial Cells

(2009) H. Raghu et al.   JOURNAL OF VIROLOGY

Virus entry by macropinocytosis

(2009) Jason Mercer et al.   NATURE CELL BIOLOGY

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS

(2008) Prisca Liberali et al.   EMBO JOURNAL

Internalization of a non-pathogenic mycobacteria by macropinocytosis in human alveolar epithelial A549 cells

(2008) Blanca Estela García-Pérez et al.   MICROBIAL PATHOGENESIS

Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse

(2008) Hiroyuki Kabayama et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

(2008) J. H. Overmeyer et al.   MOLECULAR CANCER RESEARCH

The steady-state development of splenic dendritic cells

(2008) P Sathe et al.   Mucosal Immunology

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY