IL-2 enhances ex vivo–expanded regulatory T-cell persistence after adoptive transfer

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

(2018) Eloy Cuadrado et al.   IMMUNITY

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

(2018) David Zemmour et al.   NATURE IMMUNOLOGY

Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers

(2018) Cristina Izquierdo et al.   Scientific Reports

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation

(2017) Brian C. Betts et al.   HAEMATOLOGICA

LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1

(2017) Yan-Wei Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Increased Levels of STAT1 Protein in Blood CD4 T Cells from Systemic Lupus Erythematosus Patients Are Associated with Perturbed Homeostasis of Activated CD45RA-FOXP3hi Regulatory Subset and Follow-Up Disease Severity

(2017) Aleš Goropevšek et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation

(2017) Brian C. Betts et al.   HAEMATOLOGICA

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

(2016) John Koreth et al.   BLOOD

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

(2016) Cameron McDonald-Hyman et al.   BLOOD

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice

(2015) J. N. Manirarora et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Administration of Low Doses of IL-2 Combined to Rapamycin Promotes Allogeneic Skin Graft Survival in Mice

(2014) C. B. Pilon et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Superiority of Rapamycin Over Tacrolimus in Preserving Nonhuman Primate Treg Half-Life and Phenotype After Adoptive Transfer

(2014) K. Singh et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Clustering by fast search and find of density peaks

(2014) A. Rodriguez et al.   SCIENCE

RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector

(2013) DANQI CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome

(2013) Gulbu Uzel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo

(2013) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model

(2013) Douglas C. Wu et al.   TRANSPLANTATION

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Regulatory T Cells Exhibit Decreased Proliferation but Enhanced Suppression After Pulsing With Sirolimus

(2012) K. Singh et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Low-Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant ArteriosclerosisIn Vivo

(2012) J. Hester et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells

(2011) H.-J. Shin et al.   BLOOD

IL-2 Controls the Stability of Foxp3 Expression in TGF- -Induced Foxp3+ T Cells In Vivo

(2011) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Enhancement of antigen-specific Treg vaccination in vivo

(2010) C. Daniel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

IFN-γ Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells

(2009) B. Wei et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T cells for the prevention of graft-versus-host disease: Professionals defeat amateurs

(2009) Matthias Edinger   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Mammalian Target of Rapamycin Inhibition and Alloantigen-Specific Regulatory T Cells Synergize To Promote Long-Term Graft Survival in Immunocompetent Recipients

(2009) G. Raimondi et al.   JOURNAL OF IMMUNOLOGY

Higher expression of Bax in regulatory T cells increases vascular inflammation

(2008) Zeyu Xiong   Frontiers in Bioscience-Landmark

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION