Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Singular role for T-BET+CXCR3+regulatory T cells in protection from autoimmune diabetes

(2016) Tze Guan Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

(2015) Michelle Rosenzwajg et al.   JOURNAL OF AUTOIMMUNITY

Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice

(2015) J. N. Manirarora et al.   JOURNAL OF IMMUNOLOGY

Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice

(2015) Mara Kornete et al.   PLoS One

Regulatory T Cells Prevent Transfer of Type 1 Diabetes in NOD Mice Only When Their Antigen Is Present In Vivo

(2014) D. R. Tonkin et al.   JOURNAL OF IMMUNOLOGY

In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis

(2014) N. Garabatos et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

(2014) S. A. Villalta et al.   Science Translational Medicine

Limitations of IL-2 and Rapamycin in Immunotherapy of Type 1 Diabetes

(2013) Audrey Baeyens et al.   DIABETES

Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses

(2013) Ryoko Hamano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chromogranin A is a T cell antigen in human type 1 diabetes

(2013) Peter A. Gottlieb et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice

(2013) K. E. Pauken et al.   JOURNAL OF IMMUNOLOGY

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

(2013) Agnès Hartemann et al.   Lancet Diabetes & Endocrinology

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A

(2012) T. Delong et al.   DIABETES

ICOS-Dependent Homeostasis and Function of Foxp3+ Regulatory T Cells in Islets of Nonobese Diabetic Mice

(2012) M. Kornete et al.   JOURNAL OF IMMUNOLOGY

Targeting of a T Cell Agonist Peptide to Lysosomes by DNA Vaccination Induces Tolerance in the Nonobese Diabetic Mouse

(2011) Elisa I. Rivas et al.   JOURNAL OF IMMUNOLOGY

Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ

(2010) G. Fousteri et al.   DIABETOLOGIA

Reversal of type 1 diabetes by a new MHC II-peptide chimera: “Single-epitope-mediated suppression” to stabilize a polyclonal autoimmune T-cell process

(2010) Marvin Lin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets

(2009) Markus Feuerer et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of Ongoing T Cell-Mediated Autoimmunity by Peptide-MHC Class II Dimer Vaccination

(2009) L. Li et al.   JOURNAL OF IMMUNOLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

(2008) A. M. D'Alise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA