Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart

(2015) Taishi Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

(2015) Dong I. Lee et al.   NATURE

Protein Kinase G Iα Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide

(2014) Daniel Stubbert et al.   HYPERTENSION

RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis

(2014) J. Lauriol et al.   Science Signaling

The beneficial effects of tadalafil on left ventricular dysfunction in doxorubicin-induced cardiomyopathy

(2013) Zhe Jin et al.   Journal of Cardiology

Protein kinase G oxidation is a major cause of injury during sepsis

(2013) O. Rudyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells

(2013) F Li et al.   Cell Death & Disease

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

(2013) Robert M. Blanton et al.   Journal of the American Heart Association

Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1α Knock-In Mouse

(2012) Olena Rudyk et al.   CIRCULATION

H2O2 lowers the cytosolic Ca2+ concentration via activation of cGMP-dependent protein kinase Iα

(2012) Paul Markus Müller et al.   FREE RADICAL BIOLOGY AND MEDICINE

cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation

(2012) Joseph Robert Burgoyne et al.   HYPERTENSION

Phosphodiesterase-9 (PDE9) inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide–cyclic GMP pathway in mice

(2012) F H da Silva et al.   INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase Iα

(2012) Mikio Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function

(2012) Mirko Jaumann et al.   NATURE MEDICINE

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

(2012) Oleksandra Prysyazhna et al.   NATURE MEDICINE

Mechanisms and management of doxorubicin cardiotoxicity

(2011) Y. Shi et al.   HERZ

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Nitric Oxide and Cyclic GMP as Pro-and Anti-Apoptotic Agents

(2010) Ronald R. Fiscus et al.   JOURNAL OF CARDIAC SURGERY

Long-Acting Phosphodiesterase-5 Inhibitor Tadalafil Attenuates Doxorubicin-Induced Cardiomyopathy without Interfering with Chemotherapeutic Effect

(2010) S. Koka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

(2010) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

(2008) F. Josef van der Staay et al.   NEUROPHARMACOLOGY

High blood pressure arising from a defect in vascular function

(2008) S. K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGMP-binding Prepares PKG for Substrate Binding by Disclosing the C-terminal Domain

(2007) Vera Alverdi et al.   JOURNAL OF MOLECULAR BIOLOGY