Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone

Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence

(2019) Michael O. Daniyan et al.   Biomolecules

The Link That Binds: The Linker of Hsp70 as a Helm of the Protein’s Function

(2019) Chakafana et al.   Biomolecules

Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites

(2019) Zininga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast

(2018) Weibin Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif

(2018) Blessing Mabate et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Discovering Putative Prion-Like Proteins in Plasmodium falciparum: A Computational and Experimental Analysis

(2018) Irantzu Pallarès et al.   Frontiers in Microbiology

(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

(2017) Tawanda Zininga et al.   MOLECULES

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion

(2016) Tawanda Zininga et al.   CELL STRESS & CHAPERONES

Use of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coli

(2016) Xolani Henry Makhoba et al.   PLoS One

Functionality of Class A and Class B J-protein co-chaperones with Hsp70

(2015) Hyun Young Yu et al.   FEBS LETTERS

A Functional DnaK Dimer Is Essential for the Efficient Interaction with Hsp40 Heat Shock Protein

(2015) Evans Boateng Sarbeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein

(2015) Tawanda Zininga et al.   PLoS One

C-terminal amino acids are essential for human heat shock protein 70 dimerization

(2014) Guillaume Marcion et al.   CELL STRESS & CHAPERONES

Nucleotide-Dependent Interactions within a Specialized Hsp70/Hsp40 Complex Involved in Fe–S Cluster Biogenesis

(2014) Jin Hae Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani

(2013) Saurabh Pratap Singh et al.   PLoS One

Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain

(2013) Francesco A. Aprile et al.   PLoS One

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

(2012) Simone Külzer et al.   CELLULAR MICROBIOLOGY

The C-terminal Helices of Heat Shock Protein 70 Are Essential for J-domain Binding and ATPase Activation

(2012) Xue-Chao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Allostery of the Chaperonin GroEL

(2012) Helen R. Saibil et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

(2012) Vasant Muralidharan et al.   Nature Communications

Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

(2011) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK)

(2011) Andrea D. Thompson et al.   CELL STRESS & CHAPERONES

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum

(2011) Marni Williams et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Expression of a Malarial Hsp70 Improves Defects in Chaperone-Dependent Activities in ssa1 Mutant Yeast

(2011) Samantha L. Bell et al.   PLoS One

Intracellular Protozoan Parasites of Humans: The Role of Molecular Chaperones in Development and Pathogenesis

(2011) Addmore Shonhai et al.   PROTEIN AND PEPTIDE LETTERS

Co-expression of the Plasmodium falciparum molecular chaperone, PfHsp70, improves the heterologous production of the antimalarial drug target GTP cyclohydrolase I, PfGCHI

(2011) Linda L. Stephens et al.   PROTEIN EXPRESSION AND PURIFICATION

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock

(2010) Melissa Botha et al.   CELL STRESS & CHAPERONES

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

(2009) Annette N. Chiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hsp70-1 from Plasmodium falciparum: Protein stability, domain analysis and chaperone activity

(2009) Gauri Misra et al.   BIOPHYSICAL CHEMISTRY

Plasmodial heat shock proteins: targets for chemotherapy

(2009) Addmore Shonhai   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Function Study of a Plasmodium falciparum Hsp70 Using Three Dimensional Modelling and in Vitro Analyses

(2008) Addmore Shonhai et al.   PROTEIN AND PEPTIDE LETTERS