Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

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T follicular helper cell heterogeneity: Time, space, and function

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Immunological basis for enhanced immunity of nanoparticle vaccines

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Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

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Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

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Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells

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Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay

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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

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Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization

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Immunity to Influenza is dependent on MHC II polymorphism: study with 2 HLA transgenic strains

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C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes

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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

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Virus-like particle vaccines: immunology and formulation for clinical translation

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Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

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Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

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Characterization of T-Dependent and T-Independent B Cell Responses to a Virus-like Particle

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Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D)

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Immune Response of A Novel ATR-AP205-001 Conjugate Anti-hypertensive Vaccine

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Follicular Helper T Cells

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Germinal Center B Cell Dynamics

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Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

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Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

Sequencing and cloning of antigen-specific antibodies from mouse memory B cells

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Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation

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High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

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Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

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Cutting Edge: An In Vivo Reporter Reveals Active B Cell Receptor Signaling in the Germinal Center

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Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

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Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

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Immune history profoundly affects broadly protective B cell responses to influenza

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Of mice, macaques and men: scaling of virus dynamics and immune responses

(2015) Christian L. Althaus   Frontiers in Microbiology

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

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Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

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Innate Immunity Mediates Follicular Transport of Particulate but Not Soluble Protein Antigen

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Nanoparticle-based adjuvant for enhanced protective efficacy of DNA vaccine Ag85A-ESAT-6-IL-21 against Mycobacterium tuberculosis infection

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Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

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Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

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Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes

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