Review
Immunology
Fanny Martinez, Julien Novarino, Jose Enrique Mejia, Nicolas Fazilleau, Meryem Aloulou
Summary: Environmental factors and age can affect the efficiency of the immune system, especially the decline in immune cells and cellular immunity in the elderly. Immunosenescence affects T and B cells, leading to weakened lymphocyte responses to vaccines and pathogens.
IMMUNOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Shihong Zhong, Qiong Li, Chunhua Wen, Yifan Li, Yang Zhou, Zihan Jin, Guofu Ye, Yanda Zhao, Jinlin Hou, Yongyin Li, Libo Tang
Summary: The objective of this study was to investigate the role of B cells in IFN-alpha-mediated anti-HBV cellular immunity. The results showed that B cell depletion impaired the function of T cells and delayed HBV clearance. IFN-alpha treatment enhanced the response of HBV-specific CD8+ T cells, but this effect was lost in B cell-deficient models. These findings suggest that IFN-alpha orchestrates protective HBV-specific cellular immunity in a B cell-dependent manner.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Jennifer K. King, Tiffany M. Tran, May H. Paing, Yuxin Yin, Amit K. Jaiswal, Ching-Hsuan Tso, Koushik Roy, David Casero, Dinesh S. Rao
Summary: The microRNA miR-146a is a negative regulator of the immune transcription factor NFκB and plays important roles in the immune system. Its deficiency leads to chronic inflammation and autoimmune disease. This study found that miR-146a suppresses B-cell responses and identified TRAF6 as a target gene. TRAF6 was shown to be required for proliferation in these B-cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Thomas Walle, Joscha A. Kraske, Boyu Liao, Benedicte Lenoir, Carmen Timke, Emilia von Bohlen Und Halbach, Florian Tran, Paul Griebel, Dorothee Albrecht, Azaz Ahmed, Meggy Suarez-Carmona, Alejandro Jimenez-Sanchez, Tizian Beikert, Alexandra Tietz-Dahlfuss, Ayse Nur Menevse, Gabriele Schmidt, Manuela Brom, Jens H. W. Pahl, Wiebke Antonopoulos, Matthias Miller, Ramon Lopez Perez, Felix Bestvater, Nathalia A. Giese, Philipp Beckhove, Philip Rosenstiel, Dirk Jaeger, Oliver Strobel, Dana Pe'er, Niels Halama, Juergen Debus, Adelheid Cerwenka, Peter E. Huber
Summary: NK cells play a central role in the radiation-induced immune response, enhancing tumor control through the secretion of CXCL8/IL-8 and recruiting immune cells. This discovery suggests a rational cancer treatment strategy combining NK cells with radiotherapy.
Article
Multidisciplinary Sciences
Jianmei Xiao, Xing Wan, Haoliang Wang, Guohong Deng
Summary: CD4 T cells play important roles in chronic hepatitis B and can be classified into different functional subsets based on the cytokines they secrete. Analysis of HBV-specific CD4 T cells based on cytokine secretion provides information on their response magnitude and functional subsets.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Gastroenterology & Hepatology
Ruben C. Hoogeveen, Suzan Dijkstra, Lea M. Bartsch, Hannah K. Drescher, Jasneet Aneja, Maxwell P. Robidoux, James A. Cheney, Joerg Timm, Adam Gehring, Paulo Sergio Fonseca de Sousa, Lya Ximenez, Luis Baiao Peliganga, Anita Pitts, Fiona B. Evans, Andre Boonstra, Arthur Y. Kim, Lia L. Lewis-Ximenez, Georg M. Lauer
Summary: This study compares HBV-specific T cell responses in patients with different degrees of viral control and finds that functional cure is associated with higher frequencies of functional HBV-specific CD4 memory T cell responses.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Fu-Shi Quan
Summary: This study demonstrates that influenza B virus-like particle vaccines expressing hemagglutinin, neuraminidase, or both antigens can provide cross-protections against mismatched Victoria lineage virus infections, by inducing antibody and T cell responses to reduce lung viral loads and minimize infection outcomes.
Article
Rheumatology
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzman, Gerd Sutter, Reinhold E. Schmidt, Torsten Witte, Ulrich Kalinke
Summary: Rituximab-treated patients and B cell-deficient mice showed reduced expansion of virus-specific CD8(+) T cells after vaccination/infection with different vaccines/pathogens, indicating that B cells can modulate CD8(+) T cell responses. The choice of vaccines for B cell-depleted patients needs to be re-evaluated to effectively induce protective CD8(+) T cell responses.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Mathematics
Jagdish S. Thakur, Archana Thakur, Lawrence G. Lum
Summary: Mathematical models play a crucial role in exploring the complexities of biological systems at the cellular level. In this study, a model was presented to investigate the interactions between immune cells for in vitro polyclonal antibody synthesis. The model incorporates interactions of various cells and predicts time-dependent trajectories of these cells and antibody synthesis stimulated by pokeweed mitogen.
Article
Gastroenterology & Hepatology
Yan Yan, Wei Zhao, Wei Liu, Yan Li, Xu Wang, Jingna Xun, Chantsalmaa Davgadorj
Summary: CCL19 enhances Ag-responsive IFN-γ(+) CD8(+) T cells in patients with HBV infection and promotes rapid clearance of intrahepatic HBV in mice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Virology
Anna M. Hassebroek, Harini Sooryanarain, Connie L. Heffron, Seth A. Hawks, Tanya LeRoith, Thomas E. Cecere, William B. Stone, Debra Walter, Hassan M. Mahsoub, Bo Wang, Debin Tian, Hannah M. Ivester, Irving C. Allen, Albert J. Auguste, Nisha K. Duggal, Chenming Zhang, Xiang-Jin Meng
Summary: This study developed a vaccine based on hepatitis B virus core antigen, which expressed B and T cell epitopes of SARS-CoV-2 and was evaluated for its immunogenicity and protective efficacy. The results showed that the vaccine induced specific humoral and cell-mediated immune responses, but had limited effectiveness against SARS-CoV-2 infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Julie Lucifora, Dulce Alfaiate, Caroline Pons, Maud Michelet, Ricardo Ramirez, Floriane Fusil, Fouzia Amirache, Axel Rossi, Anne-Flore Legrand, Emilie Charles, Serena Vegna, Rayan Farhat, Michel Rivoire, Guillaume Passot, Nicolas Gadot, Barbara Testoni, Charlotte Bach, Thomas F. Baumert, Anastasia Hyrina, Rudolf K. Beran, Fabien Zoulim, Andre Boonstra, Hildegard Buening, Eloi R. Verrier, Francois-Loic Cosset, Simon P. Fletcher, Anna Salvetti, David Durantel
Summary: This study elucidates the molecular mechanisms underlying how HDV interferes with HBV in patients with chronic coinfection. The researchers found that HDV induces the expression of interferon-stimulated genes (ISGs), and these genes are upregulated in HDV/HBV-coinfected patients. Inhibiting the hepatocyte's response to interferon partially restores the levels of HBV.
JOURNAL OF HEPATOLOGY
(2023)
Article
Infectious Diseases
Yuxin Chen, Shengxia Yin, Xin Tong, Yue Tao, Jun Ni, Jie Pan, Ming Li, Yawen Wan, Minxin Mao, Yali Xiong, Xiaomin Yan, Yue Yang, Rui Huang, Chao Wu, Han Shen
Summary: This study analyzed the dynamic changes of immune responses after receiving the CoronaVac vaccine. The results showed that CoronaVac can effectively induce circulating and memory B cell and T cell immune responses. Age and interval between doses affect the magnitude of immune responses.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Biochemistry & Molecular Biology
Raphael P. P. Viscidi, Treva Rowley, Ioannis Bossis
Summary: Recent research has highlighted the important role of tissue-resident memory T cells (T-RM cells) and a subset of dendritic cells in inducing strong protective immune responses. However, effective vaccine technologies that can induce robust CD8+ T cell responses through cross-priming are lacking. Here, we developed a platform technology using genetically engineered bovine papillomavirus virus-like particles (VLPs) that possess self-adjuvant properties. These polyionic VLP vaccines were able to induce robust CD8+ T cell responses in peripheral blood and tumor tissues, and outperformed other vaccines and immunotherapies for the treatment of prostate cancer in a relevant murine model. The immunogenicity of polyionic VLP vaccines depended on particle size, reversible antigen-VLP linkage, and a mechanism involving type 1 interferon and Toll-like receptor (TLR)3/7.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel, Lee Wei Lim
Summary: High-frequency stimulation (HFS) is a promising therapy for depression, and this study investigated the dopamine-dependent mechanism of the antidepressant-like effects of HFS of the prelimbic cortex (HFS PrL). The results showed that HFS PrL significantly increased hedonia, reduced anxiety, decreased forced swim immobility, and enhanced hippocampal dopamine and serotonin levels.
Article
Chemistry, Applied
Shuqin Song, Mingmei Wu, Junwei Chen, Zhuohua Mo, Rui Chen, Kun Wang, Tongwen Yu
Summary: A facile method to prepare Fe-N/S-C hybrid electrocatalysts has been developed, showing significantly improved ORR performance with high stability and methanol tolerance. This work represents a breakthrough in the development of efficient non-precious-metal catalysts to address challenges faced by Pt-based electrocatalysts.
JOURNAL OF ENERGY CHEMISTRY
(2021)
Article
Optics
Yan Liu, Qing-Yun Yu, Ze-Ming Chen, Hao-Yang Qiu, Rui Chen, Shao-Ji Jiang, Xin-Tao He, Fu-Li Zhao, Jian-Wen Dong
Summary: A meta-objective based on cascaded metalenses is proposed to achieve high-resolution microobservations, allowing clear visualization of single cell contours in biological tissues.
PHOTONICS RESEARCH
(2021)
Article
Optics
Ze-Yang Chen, Zhun Wei, Rui Chen, Jian-Wen Dong
Summary: The PhyANN scheme efficiently achieves focus shaping of high numerical aperture lens using a diffractive optical element, successfully obtaining various focus shapes without the need for labeled data training. The scheme shows potential for applications in super-resolution imaging, optical trapping, optical lithography, and more.
Article
Chemistry, Multidisciplinary
Lian He, Zixian Huang, Kai Huang, Rui Chen, Nhung T. Nguyen, Rui Wang, Xiaoli Cai, Zhiquan Huang, Stefan Siwko, Joel R. Walker, Gang Han, Yubin Zhou, Ji Jing
Summary: LiPOP is a set of optogenetic tools that can induce photoswitchable necroptosis and pyroptosis in live cells using light. Studies have shown that combining LiPOPs with upconversion nanoparticles or bioluminescence can achieve wireless optogenetic or chemo-optogenetic killing of cancer cells in multiple mouse tumor models. LiPOPs have the potential to trigger necroptotic and pyroptotic cell death in cultured cells and living animals, opening up possibilities for studying non-apoptotic cell death pathways in microbial infection and anti-tumor immunity.
Article
Pharmacology & Pharmacy
Xiaohong Sun, Haiming Xiao, Shanshan Li, Rui Chen, Zeyuan Lin, Yan Yang, Zhiquan Chen, Li Deng, Heqing Huang
Summary: This study reveals that Cx32 plays a protective role in diabetic renal tubulointerstitial fibrosis by suppressing EMT and ECM production, as well as inhibiting ROS generation in renal tubules. Mechanistically, Cx32 down-regulates PKCα expression to inhibit the formation of p22phox-NOX4 complex, leading to reduced NOX4 protein levels.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Rui Chen, Wen Bo Zhao, Xiao Pei Zhang, Hao Liang, Na Na Song, Zhu Yun Liu, Hui Xiao, Xue Ting Peng, Yang Song, Ruo Tong Liao, Wang Hui Luo, Lin Wei
Summary: This study aimed to investigate the relationship between frailty severity and long-term care needs of older adults in Chinese communities. The results showed a strong correlation between frailty and long-term care needs, with an increasing frailty degree leading to a dramatic increase in the LTC needs of older adults.
Article
Pharmacology & Pharmacy
Rui Chen, Jingran Zeng, Chuting Li, Haiming Xiao, Shanshan Li, Zeyuan Lin, Kaipeng Huang, Juan Shen, Heqing Huang
Summary: Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) in diabetic patients. Research has shown that using Fraxin (Fr) can alleviate renal fibrosis by regulating Connexin43 (Cx43) and activating the Nrf2/ARE pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Qianyu Zhang, Zixian Huang, Xi Rui, Yan Wang, Yongqiang Wang, Yuwei Zhou, Rui Chen, Yongju Chen, Yuepeng Wang, Shihao Li, Haigang Li, Ximing Shen, Yancan Liang, Yin Zhang, Zhiquan Huang
Summary: In this study, researchers discovered a non-pyroptotic role of GSDMD in promoting the sensitivity of tumor cells to cisplatin. They found that GSDMD activates the unfolded protein response, leading to cell apoptosis and increasing the effectiveness of cisplatin chemotherapy. The findings suggest that GSDMD may serve as a biomarker for cisplatin sensitivity.
CELL DEATH DISCOVERY
(2022)
Article
Pharmacology & Pharmacy
Zhanchi Xu, Meng Zhang, Yu Wang, Rui Chen, Shiyue Xu, Xiaohong Sun, Yan Yang, Zeyuan Lin, Shaogui Wang, Heqing Huang
Summary: Gentiopicroside (GPS) alleviates renal tubulointerstitial fibrosis (TIF) in diabetes by inhibiting inflammatory response and regulating protein expressions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xi Rui, Zixian Huang, Rui Chen, Yongju Chen, Yan Wang, Zhiquan Huang
Summary: The high expression of RPS3 in ACC is associated with metastasis and poor prognosis, with its regulation of the STAT1/NF-kB signaling pathway impacting migration, invasion, and chemoresistance in ACC. RPS3 may serve as a novel therapeutic target for ACC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Optics
Quan Chen, Duolan Huang, Rui Chen
Summary: This paper proposes a physics-assisted deep neural network scheme for image reconstruction in Fourier ptychographic microscopy. The scheme achieves high-resolution image reconstruction from multiple low-resolution images without the need for training. Experimental results demonstrate its effectiveness in improving image quality and robustness.
Article
Pharmacology & Pharmacy
Yan Yang, Haiming Xiao, Zeyuan Lin, Rui Chen, Shanshan Li, Chuting Li, Xiaohong Sun, Ziqing Hei, Wenyan Gong, Heqing Huang
Summary: CKIP-1 plays a nephroprotective role in diabetic nephropathy by regulating inflammation and its down-regulation exacerbates renal inflammatory fibrosis. Src kinase interacts with CKIP-1 and promotes its ubiquitination and protein degradation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Rui Chen, Yu-ke Chang, Ze-peng Zhuang, Yan Liu, Wen-jie Chen, Jian-wen Dong
Summary: In this paper, a metasurface-based fiber-to-chip multiplexing coupler is proposed, which enables flexible mode conversion and multiplexing coupling between few-mode fibers and on-chip single-mode waveguides. The approach utilizes the symmetrical characteristics of fiber eigenmodes and the freedom of light phase manipulation to achieve the desired phase distribution of metasurfaces. The use of cylindrical nanopillar as metasurface nanostructures ensures polarization independent optical response. Various fiber-to-chip multiplexing couplers are demonstrated using angular spectrum methods and finite-difference time-domain (FDTD) simulations. It is observed that two or three modes can be demultiplexed and coupled into the corresponding on-chip waveguides with low crosstalk. Furthermore, two possible fabrication schemes for multiplexing couplers are proposed, and the related fabrication tolerances and misalignment effects are evaluated and discussed. Metasurface-based couplers offer advantages of ultracompact footprint and low crosstalk compared to traditional on-chip couplers. This study explores the application of metasurfaces in multiplexing coupling between few-mode fiber and on-chip single-mode waveguides, which is expected to overcome the bottleneck of current mode-division multiplexing technologies in optical interconnection and meet the increasing demand for large data throughput of photonic integrated chips.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zixian Huang, Yongju Chen, Rui Chen, Bin Zhou, Yongqiang Wang, Lei Hong, Yuepeng Wang, Jianguang Wang, Xiaoding Xu, Zhiquan Huang, Weiliang Chen
Summary: SERPINB3 is identified as an important target for regulating cisplatin sensitivity in HNSCC induced by HPV infection. Decreased SERPINB3 expression enhances the cytotoxicity of cisplatin by interfering with DNA damage repair and promoting HNSCC cell apoptosis. Using pH-responsive nanoparticles to deliver SERPINB3 small interfering RNA in combination with cisplatin successfully reverses cisplatin chemotherapeutic resistance.
Article
Critical Care Medicine
Lin Lin, Pengfei Wang, Houzhen Zheng, Zheye Zhong, Yongxun Zhuansun, Zhengfei Yang, Rui Chen
Summary: Gasping during cardiac arrest is characterized by high tidal volume, low minute ventilation, and prolonged expiratory time. The increased work of breathing and insufficient neuromechanical efficacy of neural respiratory drive suggest the importance of mechanical ventilation and appropriate management strategies during resuscitation after cardiac arrest.