The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-05
DOI
10.3389/fonc.2020.00799
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells
- (2019) Hui Du et al. Analytical Cellular Pathology
- Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production
- (2019) Yasuhiko Koga et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway
- (2019) Hee-Don Chae et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Protein kinase A-induced phosphorylation at the Thr154 affects stability of DJ-1
- (2019) Yeon Uk Ko et al. PARKINSONISM & RELATED DISORDERS
- Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition
- (2019) Rong Xu et al. Journal of Oncology
- Disulfiram/copper causes ROS levels alteration, cell cycle inhibition, and apoptosis in acute myeloid leukaemia cell lines with modulation in the expression of related genes
- (2018) Saeed Hassani et al. BIOMEDICINE & PHARMACOTHERAPY
- Cancer statistics, 2018
- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation
- (2018) Katerina Rejlova et al. Epigenetics
- Targeting transcription factors in acute myeloid leukemia
- (2018) Hisashi Takei et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
- (2018) Yunan Li et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Peptidomimetic blockade of MYB in acute myeloid leukemia
- (2018) Kavitha Ramaswamy et al. Nature Communications
- Forskolin Sensitizes Human Acute Myeloid Leukemia Cells to H3K27me2/3 Demethylases GSKJ4 Inhibitor via Protein Kinase A
- (2018) Michela Illiano et al. Frontiers in Pharmacology
- Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia
- (2018) Younguk Sun et al. Frontiers in Oncology
- Tumor suppressive role for kinases phosphorylating p53 in the DNA damage-induced apoptosis
- (2018) Satomi Yogosawa et al. CANCER SCIENCE
- The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus
- (2018) Kelin L. Wheaton et al. JOURNAL OF BIOLOGICAL RHYTHMS
- Silica/Polyethylene Glycol Hybrid Materials Prepared by a Sol-Gel Method and Containing Chlorogenic Acid
- (2018) Michelina Catauro et al. MOLECULES
- Clinical epigenetics: seizing opportunities for translation
- (2018) María Berdasco et al. NATURE REVIEWS GENETICS
- GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells
- (2017) Ningning Yan et al. EXPERIMENTAL CELL RESEARCH
- Emerging therapies for acute myeloid leukemia
- (2017) Caner Saygin et al. Journal of Hematology & Oncology
- RNA editing signature during myeloid leukemia cell differentiation
- (2017) C Rossetti et al. LEUKEMIA
- Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways
- (2017) Hee-Don Chae et al. Oncotarget
- The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
- (2017) Aixia Sui et al. Oncotarget
- Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors
- (2017) Maithili P. Dalvi et al. Cell Reports
- Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia
- (2017) Rui Lu et al. Frontiers in Oncology
- The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
- (2016) Andreas C. Joerger et al. Annual Review of Biochemistry
- Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin
- (2016) HIKARU WATARAI et al. ANTICANCER RESEARCH
- Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
- (2016) Hartmut Döhner et al. BLOOD
- Identification and characterization of PKF118-310 as a KDM4A inhibitor
- (2016) Gianluigi Franci et al. Epigenetics
- Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs
- (2016) Rohit Mathur et al. HAEMATOLOGICA
- CREB engages C/EBPδ to initiate leukemogenesis
- (2016) C Tregnago et al. LEUKEMIA
- Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells
- (2016) B Mitton et al. LEUKEMIA
- ‘Acute myeloid leukemia: a comprehensive review and 2016 update’
- (2016) I De Kouchkovsky et al. Blood Cancer Journal
- Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target
- (2016) André Steven et al. Oncotarget
- Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs
- (2016) Rohit Mathur et al. HAEMATOLOGICA
- Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2–MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide
- (2016) Alejandro Huante-Mendoza et al. Frontiers in Immunology
- Decrease of phosphorylated proto-oncogeneCREBat Ser 133 site inhibits growth and metastatic activity of renal cell cancer
- (2015) Xue Wang et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Post-translational control of transcription factors: methylation ranks highly
- (2015) Simon M. Carr et al. FEBS Journal
- Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300
- (2015) S. Uttarkar et al. MOLECULAR CANCER THERAPEUTICS
- Targeting novel signaling pathways for resistant acute myeloid leukemia
- (2015) Kathleen M. Sakamoto et al. MOLECULAR GENETICS AND METABOLISM
- A small-molecule inhibitor of the aberrant transcription factor CBF -SMMHC delays leukemia in mice
- (2015) A. Illendula et al. SCIENCE
- CREB phosphorylation at Ser133regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling
- (2014) Shaista Naqvi et al. BIOCHEMICAL JOURNAL
- Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
- (2014) Panagiotis Ntziachristos et al. NATURE
- Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
- (2014) Rintaro Hashizume et al. NATURE MEDICINE
- Molecular Basis of NF-κB Signaling
- (2013) Johanna Napetschnig et al. Annual Review of Biophysics
- MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation
- (2013) M. Pigazzi et al. HAEMATOLOGICA
- Signal transducers and activators of transcription—from cytokine signalling to cancer biology
- (2011) Cristina Isabel Santos et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- miR-34b Targets Cyclic AMP-Responsive Element Binding Protein in Acute Myeloid Leukemia
- (2009) M. Pigazzi et al. CANCER RESEARCH
- Degradation of cAMP-Responsive Element-Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in -Cells and Human Pancreatic Islets
- (2009) S. Costes et al. DIABETES
- Regulating gene transcription in response to cyclic AMP elevation
- (2007) William A. Sands et al. CELLULAR SIGNALLING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now