Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition

The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer

(2018) Jung-Jin Park et al.   ONCOGENE

Non-redundant functions of EMT transcription factors

(2018) Marc P. Stemmler et al.   NATURE CELL BIOLOGY

The multiverse nature of epithelial to mesenchymal transition

(2018) Pasquale Simeone et al.   SEMINARS IN CANCER BIOLOGY

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1

(2017) Ji-Hyung Lee et al.   NATURE CELL BIOLOGY

Targeting Lyn regulates Snail family shuttling and inhibits metastasis

(2017) D Thaper et al.   ONCOGENE

Correlation of Snail expression and survival in patients with early-stage triple-negative breast cancer (TNBC).

(2017) S. Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

(2016) Chia-Wei Li et al.   CANCER RESEARCH

Phosphorylation Regulates Functions of ZEB1 Transcription Factor

(2016) M. Candelaria Llorens et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer

(2016) Wenhui Zhou et al.   Cell Reports

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

(2015) Reetta Virtakoivu et al.   CANCER RESEARCH

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

(2015) Peijing Zhang et al.   CELL CYCLE

An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors

(2015) Andrew T. Chang et al.   GENES & DEVELOPMENT

PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer

(2015) Sreedevi Avasarala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Twist predicts poor outcome of patients with astrocytic glioma

(2015) Kristiina Nordfors et al.   JOURNAL OF CLINICAL PATHOLOGY

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

(2015) Rajendra P. Gajula et al.   NEOPLASIA

PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial-Mesenchymal Transition and Radioresistance in Lung Cancer Cells

(2014) E. Kim et al.   CANCER RESEARCH

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

Slug is temporally regulated by cyclin E in cell cycle and controls genome stability

(2014) W-L Wang et al.   ONCOGENE

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

GSK3β controls epithelial–mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug

(2013) S-H Kao et al.   ONCOGENE

Zinc finger E-box binding homeobox 1 promotes invasion and bone metastasis of small cell lung cancerin vitroandin vivo

(2012) Yi Liu et al.   CANCER SCIENCE

Functional regulation of Slug / Snail2 is dependent on GSK-3β-mediated phosphorylation

(2012) Jin Young Kim et al.   FEBS Journal

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction

(2012) A Deshiere et al.   ONCOGENE

Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

(2012) Gongda Xue et al.   Cancer Discovery

Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness

(2011) J. Hong et al.   CANCER RESEARCH

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation

(2011) Kun Zhang et al.   EMBO JOURNAL

14-3-3 Binding Sites in the Snail Protein Are Essential for Snail-Mediated Transcriptional Repression and Epithelial-Mesenchymal Differentiation

(2010) Zhaoyuan Hou et al.   CANCER RESEARCH

Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of Snail

(2010) C. Du et al.   CANCER RESEARCH

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

(2010) Sang Yoon Park et al.   EMBO JOURNAL

Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

(2010) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcription

(2010) H. L. Franco et al.   NUCLEIC ACIDS RESEARCH

Role of CK1 in GSK3β-mediated phosphorylation and degradation of Snail

(2010) Y Xu et al.   ONCOGENE

The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells

(2009) J. Wang et al.   INTERNATIONAL IMMUNOLOGY

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors

(2009) J.-M. Mingot et al.   JOURNAL OF CELL SCIENCE

The class I bHLH factors E2-2A and E2-2B regulate EMT

(2009) V. R. Sobrado et al.   JOURNAL OF CELL SCIENCE

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

(2009) Douglas S. Micalizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of Serine 11 and Serine 92 as New Positive Regulators of Human Snail1 Function: Potential Involvement of Casein Kinase-2 and the cAMP-activated Kinase Protein Kinase A

(2009) Matthew Reid MacPherson et al.   MOLECULAR BIOLOGY OF THE CELL

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

Zeb1 links epithelial-mesenchymal transition and cellular senescence

(2008) Y. Liu et al.   DEVELOPMENT

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 To Mediate SNAIL-Dependent Transcriptional Repression

(2008) Z. Hou et al.   MOLECULAR AND CELLULAR BIOLOGY