Post-translational control of transcription factors: methylation ranks highly

The oxygenase Jmjd6–a case study in conflicting assignments

(2015) Angelika Böttger et al.   BIOCHEMICAL JOURNAL

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

(2015) L Zhao et al.   CELL DEATH AND DIFFERENTIATION

Advances in the development of histone lysine demethylase inhibitors

(2015) Tamara Maes et al.   CURRENT OPINION IN PHARMACOLOGY

Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9

(2015) Aarthi V. Maganti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylation of Gata3 Protein at Arg-261 Regulates Transactivation of theIl5Gene in T Helper 2 Cells

(2015) Hiroyuki Hosokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer

(2015) Sreedevi Avasarala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting histone lysine methylation in cancer

(2015) John McGrath et al.   PHARMACOLOGY & THERAPEUTICS

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

(2015) Y. Li et al.   Cancer Discovery

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

(2015) Rebecca Cook et al.   Cell Reports

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

(2015) Hyun-Soo Cho et al.   NEOPLASIA

Readers of histone methylarginine marks

(2014) Sitaram Gayatri et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Towards understanding methyllysine readout

(2014) Catherine A. Musselman et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Selective Inhibitors of Protein Methyltransferases

(2014) H. Ümit Kaniskan et al.   JOURNAL OF MEDICINAL CHEMISTRY

PRMT4-Mediated Arginine Methylation Negatively Regulates Retinoblastoma Tumor Suppressor Protein and Promotes E2F-1 Dissociation

(2014) Kevin Y. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

A Methylation-Phosphorylation Switch Determines Sox2 Stability and Function in ESC Maintenance or Differentiation

(2014) Lan Fang et al.   MOLECULAR CELL

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

(2014) S. M. Carr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roles of Jumonji-type oxygenases in human disease

(2014) Catrine Johansson et al.   Epigenomics

Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation

(2013) Clare C Davies et al.   EMBO JOURNAL

Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

(2013) Xiangxiang Bao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

(2013) Caroline J. DeHart et al.   MOLECULAR & CELLULAR PROTEOMICS

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1

(2013) Shunsheng Zheng et al.   MOLECULAR CELL

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

(2013) Lindsey I James et al.   Nature Chemical Biology

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of lysine methylation of NF- B in differential gene regulation

(2013) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

(2013) Tiejun Zhang et al.   Nature Communications

Arginine methylation controls growth regulation by E2F-1

(2012) Er-Chieh Cho et al.   EMBO JOURNAL

NEDDylation regulates E2F-1-dependent transcription

(2012) Sarah J Loftus et al.   EMBO REPORTS

Emerging roles of RB family: New defense mechanisms against tumor progression

(2012) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

(2012) Gaofeng Cui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NEDDylation controls the target specificity of E2F1 and apoptosis induction

(2012) I Aoki et al.   ONCOGENE

Reactivation of the Tumour Suppressor RASSF1A in Breast Cancer by Simultaneous Targeting of DNA and E2F1 Methylation

(2012) María F. Montenegro et al.   PLoS One

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

(2011) J. He et al.   BLOOD

Methylation-mediated regulation of E2F1 in DNA damage-induced cell death

(2011) Qi Xie et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

p53-Dependent Transcription and Tumor Suppression Are Not Affected in Set7/9-Deficient Mice

(2011) Bernhard Lehnertz et al.   MOLECULAR CELL

The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo

(2011) Stefano Campaner et al.   MOLECULAR CELL

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

(2010) Simon M Carr et al.   EMBO JOURNAL

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

(2010) Lihong Chen et al.   EMBO JOURNAL

Methylation of the Retinoblastoma Tumor Suppressor by SMYD2

(2010) Louis A. Saddic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression

(2010) Lisandra E. West et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine Methylation Regulates E2F1-Induced Cell Death

(2010) Haroula Kontaki et al.   MOLECULAR CELL

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Lysine methylation regulates the pRb tumour suppressor protein

(2010) S Munro et al.   ONCOGENE

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

pRb, a local chromatin organizer with global possibilities

(2009) Michelle S. Longworth et al.   CHROMOSOMA

Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit

(2009) Xiao-Dong Yang et al.   EMBO JOURNAL

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

(2009) M. Barradas et al.   GENES & DEVELOPMENT

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF B

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF-κB activity through lysine monomethylation of p65

(2009) Chee-Kwee Ea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

(2008) X. Zhao et al.   GENES & DEVELOPMENT

Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-κB-dependent Inflammatory Genes

(2008) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for 53BP1 Tudor Domain Recognition of p53 Dimethylated at Lysine 382 in DNA Damage Signaling

(2008) Ioulia Kachirskaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1

(2008) Muriel Le Romancer et al.   MOLECULAR CELL

Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo

(2008) Julia K. Kurash et al.   MOLECULAR CELL

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY

A complex barcode underlies the heterogeneous response of p53 to stress

(2008) Fiona Murray-Zmijewski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conserved functions of the pRB and E2F families

(2008) Sander van den Heuvel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY