Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration

Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

(2021) Marco Leibinger et al.   Nature Communications

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

(2021) Takashi Nishina et al.   Nature Communications

A transcriptional switch governs fibroblast activation in heart disease

(2021) Michael Alexanian et al.   NATURE

Gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration

(2020) Yandong Li et al.   CIRCULATION

Cellular diversity of the regenerating caudal fin

(2020) Yiran Hou et al.   Science Advances

Microglia-organized scar-free spinal cord repair in neonatal mice

(2020) Yi Li et al.   NATURE

STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

(2020) Andrew J. Paris et al.   NATURE CELL BIOLOGY

Gene regulatory networks controlling vertebrate retinal regeneration

(2020) Thanh Hoang et al.   SCIENCE

Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates

(2020) Wei Wang et al.   SCIENCE

Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

(2020) Laura Alonso-Herranz et al.   eLife

Endothelial to Mesenchymal Transition in Cardiovascular Disease

(2019) Jason C. Kovacic et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure

(2019) Jing Ye et al.   MEDIATORS OF INFLAMMATION

IL ‐6 trans‐signaling controls liver regeneration after partial hepatectomy

(2019) Nastaran Fazel Modares et al.   HEPATOLOGY

Deep evolutionary origin of limb and fin regeneration

(2019) Sylvain Darnet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish

(2019) Veronika Miskolci et al.   eLife

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

(2019) Benjamin Ng et al.   Science Translational Medicine

TGF-β Signaling Promotes Tissue Formation during Cardiac Valve Regeneration in Adult Zebrafish

(2019) Anabela Bensimon-Brito et al.   DEVELOPMENTAL CELL

Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation

(2019) Rubén Marín-Juez et al.   DEVELOPMENTAL CELL

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Simultaneous lineage tracing and cell-type identification using CRISPR–Cas9-induced genetic scars

(2018) Bastiaan Spanjaard et al.   NATURE BIOTECHNOLOGY

Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart

(2018) Héctor Sánchez-Iranzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The local microenvironment limits the regenerative potential of the mouse neonatal heart

(2018) Mario Notari et al.   Science Advances

Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise

(2018) Srdjan Boskovic et al.   PLoS One

Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration

(2018) Tobias Gerber et al.   SCIENCE

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Transient cardiomyocyte fusion regulates cardiac development in zebrafish

(2017) Suphansa Sawamiphak et al.   Nature Communications

interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration

(2017) Hiroshi Tsujioka et al.   Nature Communications

Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair

(2017) Deepika Dogra et al.   Nature Communications

Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation

(2017) Yinzi Liu et al.   PLoS Genetics

Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration

(2017) Shih-Lei Lai et al.   eLife

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in MiceNovelty and Significance

(2016) Harmandeep Kaur et al.   CIRCULATION RESEARCH

2C-Cas9: a versatile tool for clonal analysis of gene function

(2016) Vincenzo Di Donato et al.   GENOME RESEARCH

Four cases of investigational therapy with interleukin-11 against acute myocardial infarction

(2016) Masashi Nakagawa et al.   HEART AND VESSELS

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration

(2016) W. C. W. Chen et al.   Science Advances

Dynamic remodeling of the extra cellular matrix during zebrafish fin regeneration

(2015) Jayalakshmi Govindan et al.   GENE EXPRESSION PATTERNS

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration

(2013) Jinhu Wang et al.   DEVELOPMENTAL BIOLOGY

Myofibroblasts: Trust your heart and let fate decide

(2013) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration

(2013) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling

(2011) Thomas Kubin et al.   Cell Stem Cell

tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

(2011) K. Kikuchi et al.   DEVELOPMENT

Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration

(2011) S. Sousa et al.   DEVELOPMENT

Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish

(2011) J. M. Gonzalez-Rosa et al.   DEVELOPMENT

Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin

(2011) Franziska Knopf et al.   DEVELOPMENTAL CELL

Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

(2011) Kazu Kikuchi et al.   DEVELOPMENTAL CELL

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Trpv5/6 is vital for epithelial calcium uptake and bone formation

(2011) Jo Vanoevelen et al.   FASEB JOURNAL

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

(2010) Masanori Obana et al.   CIRCULATION

Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish

(2010) C. Mosimann et al.   DEVELOPMENT

A transitional extracellular matrix instructs cell behavior during muscle regeneration

(2010) Sarah Calve et al.   DEVELOPMENTAL BIOLOGY

Zebrafish cardiac enhancer trap lines: New tools for in vivo studies of cardiovascular development and disease

(2010) Kar-Lai Poon et al.   DEVELOPMENTAL DYNAMICS

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinct populations of quiescent and proliferative pancreatic  -cells identified by HOTcre mediated labeling

(2009) D. Hesselson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression and functional analysis of zebrafish larval fin fold regeneration

(2008) Nozomi Yoshinari et al.   DEVELOPMENTAL BIOLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE