A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

(2020) Brooke Armistead et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records

(2020) Huijun Chen et al.   LANCET

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Placental Pathology in COVID-19

(2020) Elisheva D Shanes et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State

(2020) Erica M. Lokken et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Coronavirus disease 2019 in pregnant women: a report based on 116 cases

(2020) Jie Yan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Visualization of SARS-CoV-2 virus invading the human placenta using electron microscopy

(2020) Gabriela N. Algarroba et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

(2020) Simonetta Costa et al.   AMERICAN JOURNAL OF PERINATOLOGY

Severe COVID-19 during Pregnancy and Possible Vertical Transmission

(2020) Maria Claudia Alzamora et al.   AMERICAN JOURNAL OF PERINATOLOGY

An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes

(2020) David A. Schwartz   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Vaginal delivery in SARS‐CoV‐2‐infected pregnant women in Northern Italy: a retrospective analysis

(2020) E Ferrazzi et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Evidence of mother-to-newborn infection with COVID-19

(2020) Mingyang Sun et al.   BRITISH JOURNAL OF ANAESTHESIA

Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection

(2020) Maksim Kirtsman et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

A Case Report of Neonatal 2019 Coronavirus Disease in China

(2020) Shaoshuai Wang et al.   CLINICAL INFECTIOUS DISEASES

Novel Coronavirus Infection in Newborn Babies Under 28 Days in China

(2020) Zhi-Jiang Zhang et al.   EUROPEAN RESPIRATORY JOURNAL

Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals

(2020) Liona C. Poon et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection

(2020) David Baud et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antibodies in Infants Born to Mothers With COVID-19 Pneumonia

(2020) Hui Zeng et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

(2020) Lan Dong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

COVID-19: towards controlling of a pandemic

(2020) Juliet Bedford et al.   LANCET

Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study

(2020) Nan Yu et al.   LANCET INFECTIOUS DISEASES

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vertical Transmission in Neonates Born to Mothers With Coronavirus Disease 2019 (COVID-19) Pneumonia

(2020) Xiaolin Hu et al.   OBSTETRICS AND GYNECOLOGY

Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings

(2020) Rebecca N Baergen et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study

(2020) Mengmeng Li et al.   PLoS One

Preterm delivery in pregnant woman with critical COVID ‐19 pneumonia and vertical transmission

(2020) Marzieh Zamaniyan et al.   PRENATAL DIAGNOSIS

Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China

(2020) Lingkong Zeng et al.   JAMA Pediatrics

Clinical characteristics of 19 neonates born to mothers with COVID-19

(2020) Wei Liu et al.   Frontiers of Medicine

Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth

(2020) Loïc Sentilhes et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Vertical Transmission of SARS-CoV-2: What is the Optimal Definition?

(2020) Dean A. Blumberg et al.   AMERICAN JOURNAL OF PERINATOLOGY

Analysis of complement deposition and viral RNA in placentas of COVID-19 patients

(2020) J. Justin Mulvey et al.   Annals of Diagnostic Pathology

Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis

(2020) KF Walker et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Association of COVID-19 with pregnancy outcomes in health-care workers and general women

(2020) S. Khan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2

(2020) Charles Egloff et al.   JOURNAL OF CLINICAL VIROLOGY

Report of Positive Placental Swabs for SARS-CoV-2 in an Asymptomatic Pregnant Woman with COVID-19

(2020) Antonella Ferraiolo et al.   Medicina-Lithuania

Factors preventing materno-fetal transmission of SARS-CoV-2

(2020) Onder Celik et al.   PLACENTA

Transplacental transmission of SARS-CoV-2 infection

(2020) Alexandre J. Vivanti et al.   Nature Communications

Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study

(2020) Marian Knight et al.   BMJ-British Medical Journal

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

(2020) Roger Pique-Regi et al.   eLife

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

(2020) Chaofu Wang et al.   EBioMedicine

COVID-19 in Pregnant Women and Neonates: A Systematic Review of the Literature with Quality Assessment of the Studies

(2020) Giulia Trippella et al.   Pathogens

A snapshot of the Covid-19 pandemic among pregnant women in France

(2020) Gilles Kayem et al.   Journal of Gynecology Obstetrics and Human Reproduction

COVID-19 in a 26-week preterm neonate

(2020) Fiammetta Piersigilli et al.   Lancet Child & Adolescent Health

The MERS-CoV Receptor DPP4 as a Candidate Binding Target of the SARS-CoV-2 Spike

(2020) Yu Li et al.   iScience

SARS–CoV-2 infection of the placenta

(2020) Hillary Hosier et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart

(2019) Yueli Cui et al.   Cell Reports

The role of basigin in reproduction

(2019) Kailiang Li et al.   REPRODUCTION

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance

(2019) Marta Magatti et al.   Cells

The Placenta as a Window to Maternal Vascular Health

(2019) W. Tony Parks et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Recent Updates on Research Models and Tools to Study Virus–Host Interactions at the Placenta

(2019) Jae Kyung Lee et al.   Viruses-Basel

Single cell transcriptional signatures of the human placenta in term and preterm parturition

(2019) Roger Pique-Regi et al.   eLife

Macrophages — a perspective target for antineoplastic immunotherapy

(2019) О.М. Karaman et al.   Experimental Oncology

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

(2018) Giuliano G. Stirparo et al.   DEVELOPMENT

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

Insight into the development of obesity: functional alterations of adipose-derived mesenchymal stem cells

(2018) F. Louwen et al.   Obesity Reviews

High-throughput immunophenotypic characterization of bone marrow- and cord blood-derived mesenchymal stromal cells reveals common and differentially expressed markers: identification of angiotensin-converting enzyme (CD143) as a marker differentially expressed between adult and perinatal tissue sources

(2018) Eliana Amati et al.   Stem Cell Research & Therapy

Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta

(2018) Mónica S. Ventura Ferreira et al.   Stem Cell Research & Therapy

Maternal vascular malperfusion of the placental bed

(2018) Linda M. Ernst   APMIS

Defense and infection of the human placenta

(2018) Amy Heerema-McKenney   APMIS

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

Type III Interferons in Antiviral Defenses at Barrier Surfaces

(2018) Alexandra I. Wells et al.   TRENDS IN IMMUNOLOGY

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems

(2018) Hiroshi Fujiwara et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis

(2018) Saifon Chawanpaiboon et al.   Lancet Global Health

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

(2018) Leticia Reyes et al.   Frontiers in Immunology

A single-cell survey of the human first-trimester placenta and decidua

(2018) Hemant Suryawanshi et al.   Science Advances

The role of decidual immune cells on human pregnancy

(2017) Su Liu et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The role of ACE2, angiotensin-(1–7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction

(2017) Elham Ghadhanfar et al.   Reproductive Biology and Endocrinology

Cellular and molecular mechanisms of viral infection in the human placenta

(2017) Moises León-Juárez et al.   Pathogens and Disease

Zika virus infection of Hofbauer cells

(2016) Michael K. Simoni et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

(2016) Avraham Bayer et al.   Cell Host & Microbe

Principles of Virus Uncoating: Cues and the Snooker Ball

(2016) Yohei Yamauchi et al.   TRAFFIC

Human trophoblasts confer resistance to viruses implicated in perinatal infection

(2015) Avraham Bayer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Viral Infections During Pregnancy

(2015) Michelle Silasi et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Placenta: The Forgotten Organ

(2015) Emin Maltepe et al.   Annual Review of Cell and Developmental Biology

The placenta: a multifaceted, transient organ

(2015) G. J. Burton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The rat placental renin-angiotensin system - a gestational gene expression study

(2015) Kanchan Vaswani et al.   Reproductive Biology and Endocrinology

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Cardiovascular disease risk in women with a history of spontaneous preterm delivery: A systematic review and meta-analysis

(2015) Karst Y Heida et al.   European Journal of Preventive Cardiology

Toll-like Receptors at the Maternal-Fetal Interface in Normal Pregnancy and Pregnancy Complications

(2014) Kaori Koga et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

The intricate interplay between RNA viruses and NF-κB

(2014) M. Lienhard Schmitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of trophoblastic microRNAs in placental viral infection

(2014) Jean-Francois Mouillet et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Human Trophoblasts Recruited T Lymphocytes and Monocytes into Decidua by Secretion of Chemokine CXCL16 and Interaction with CXCR6 in the First-Trimester Pregnancy

(2014) Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Beyond pregnancy: modulation of trophoblast invasion and its consequences for fetal growth and long-term children's health

(2014) Perrie F. O’Tierney-Ginn et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization

(2014) Z. Zhou et al.   PLACENTA

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

The Placenta as a Barrier to Viral Infections

(2014) Elizabeth Delorme-Axford et al.   Annual Review of Virology

Immunology of the Maternal-Fetal Interface

(2013) Adrian Erlebacher   Annual Review of Immunology

Elevated hyaluronan and extracellular matrix metalloproteinase inducer levels in women with preeclampsia

(2013) Mariana Romão et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Autophagy as a mechanism of antiviral defense at the maternal–fetal interface

(2013) Elizabeth Delorme-Axford et al.   Autophagy

EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone

(2013) Yiping Dang et al.   BIOCHEMICAL PHARMACOLOGY

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

(2013) Ole J Hamming et al.   EMBO JOURNAL

Identification of CD147 (basigin) as a mediator of trophoblast functions

(2013) Cheuk-Lun Lee et al.   HUMAN REPRODUCTION

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Review: Placenta-specific microRNAs in exosomes – Good things come in nano-packages

(2013) Y. Ouyang et al.   PLACENTA

Human placental trophoblasts confer viral resistance to recipient cells

(2013) E. Delorme-Axford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placental Syncytium Forms a Biophysical Barrier against Pathogen Invasion

(2013) Varvara B. Zeldovich et al.   PLoS Pathogens

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling

(2013) Martin Knöfler et al.   Frontiers in Genetics

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Inflammation and pregnancy: the role of the immune system at the implantation site

(2011) Gil Mor et al.   Annals of the New York Academy of Sciences

Nuclear Factor-κB: a Key Regulator in Health and Disease of Lungs

(2011) Sanjay Batra et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Pathogens and the placental fortress

(2011) Jennifer R Robbins et al.   CURRENT OPINION IN MICROBIOLOGY

Angiotensin-Converting Enzyme 2 Deficiency Is Associated With Impaired Gestational Weight Gain and Fetal Growth Restriction

(2011) Manish S. Bharadwaj et al.   HYPERTENSION

The role of the Nod-like receptor family in trophoblast innate immune responses

(2011) Vikki M. Abrahams   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The expression and localization of the human placental prorenin/renin-angiotensin system throughout pregnancy: Roles in trophoblast invasion and angiogenesis?

(2011) K.G. Pringle et al.   PLACENTA

The Unique Properties of Uterine NK Cells

(2010) Irit Manaster et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Placental Apoptosis in Health and Disease

(2010) Andrew N. Sharp et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Over-expression of caveolin-1 aggravate LPS-induced inflammatory response in AT-1 cells via up-regulation of cPLA2/p38 MAPK

(2010) Xue-Jun Lv et al.   INFLAMMATION RESEARCH

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Chronic intervillositis of the placenta: A systematic review

(2010) E. Contro et al.   PLACENTA

Mechanisms of viral entry: sneaking in the front door

(2010) Jennifer A. Thorley et al.   PROTOPLASMA

Placental Syncytiotrophoblast Constitutes a Major Barrier to Vertical Transmission of Listeria monocytogenes

(2010) Jennifer R. Robbins et al.   PLoS Pathogens

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy, antiviral immunity, and viral countermeasures

(2009) Sanae Shoji-Kawata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes1

(2009) Shan-Shun Luo et al.   BIOLOGY OF REPRODUCTION

Villitis of Unknown Etiology Is Associated with a Distinct Pattern of Chemokine Up-Regulation in the Feto-Maternal and Placental Compartments: Implications for Conjoint Maternal Allograft Rejection and Maternal Anti-Fetal Graft-versus-Host Disease

(2009) M. J. Kim et al.   JOURNAL OF IMMUNOLOGY

Adhesion Molecules in Human Trophoblast – A Review. I. Villous Trophoblast

(2009) J.D. Aplin et al.   PLACENTA

The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion

(2009) Z. Zhou et al.   PLACENTA

The expression of caveolin-1 and the distribution of caveolae in the murine placenta and yolk sac: Parallels to the human placenta

(2009) S. Mohanty et al.   PLACENTA

SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro

(2009) Susan F. Dosch et al.   VIRUS RESEARCH

Functional Characterization of the Human Placental Fusogenic Membrane Protein Syncytin 21

(2008) Chie-Pein Chen et al.   BIOLOGY OF REPRODUCTION

Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy

(2008) C. Carlino et al.   BLOOD

Basigin-Mediated Gene Expression Changes in Mouse Uterine Stromal Cells During Implantation

(2008) Li Chen et al.   ENDOCRINOLOGY

The placenta in pre-eclampsia and intrauterine growth restriction

(2008) D J Roberts et al.   JOURNAL OF CLINICAL PATHOLOGY

Whole-genome microarray and targeted analysis of angiogenesis-regulating gene expression (ENG, FLT1, VEGF, PlGF) in placentas from pre-eclamptic and small-for-gestational-age pregnancies

(2008) Johanne Holm Toft et al.   Journal of Maternal-Fetal & Neonatal Medicine

Profiling Gene Expression in Human Placentae of Different Gestational Ages: An OPRU* Network and UW SCOR Study

(2008) Andrei M. Mikheev et al.   Reproductive Sciences

ACE2 and ANG-(1-7) in the rat uterus during early and late gestation

(2007) Liomar A. A. Neves et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY