Recent Updates on Research Models and Tools to Study Virus–Host Interactions at the Placenta

Interferon lambda protects the female reproductive tract against Zika virus infection

(2019) Elizabeth A. Caine et al.   Nature Communications

Advances in Zika Virus–Host Cell Interaction: Current Knowledge and Future Perspectives

(2019) Jae Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human placenta has no microbiome but can contain potential pathogens

(2019) Marcus C. de Goffau et al.   NATURE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

LASSA FEVER IN PREGNANCY WITH A POSITIVE MATERNAL AND FETAL OUTCOME: A CASE REPORT

(2019) Joseph Agboeze et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Protective and Pathogenic Effects of Interferon Signaling During Pregnancy

(2019) Rebecca L. Casazza et al.   VIRAL IMMUNOLOGY

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

(2018) Pamela Ferretti et al.   Cell Host & Microbe

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

(2018) Dawn M. Dudley et al.   NATURE MEDICINE

Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

(2018) Derek J. Platt et al.   Science Translational Medicine

In vitro placenta barrier model using primary human trophoblasts, underlying connective tissue and vascular endothelium

(2018) Akihiro Nishiguchi et al.   BIOMATERIALS

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age

(2018) Jennifer Barrila et al.   INFECTION AND IMMUNITY

Placentation defects are highly prevalent in embryonic lethal mouse mutants

(2018) Vicente Perez-Garcia et al.   NATURE

Congenital Viral Infection: Traversing the Uterine-Placental Interface

(2018) Lenore Pereira   Annual Review of Virology

Regulation of Placental Development and Its Impact on Fetal Growth—New Insights From Mouse Models

(2018) Laura Woods et al.   Frontiers in Endocrinology

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy

(2018) Elizabeth Q. Littauer et al.   Frontiers in Immunology

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

(2018) Leticia Reyes et al.   Frontiers in Immunology

A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier

(2018) Fangchao Yin et al.   TOXICOLOGY IN VITRO

Risks associated with viral infections during pregnancy

(2017) Karen Racicot et al.   JOURNAL OF CLINICAL INVESTIGATION

Progesterone-Based Contraceptives Reduce Adaptive Immune Responses and Protection against Sequential Influenza A Virus Infections

(2017) Olivia J. Hall et al.   JOURNAL OF VIROLOGY

A guinea pig model of Zika virus infection

(2017) Mukesh Kumar et al.   Virology Journal

Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication

(2017) Kjersti M. Aagaard et al.   Scientific Reports

H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation

(2017) Elizabeth Q. Littauer et al.   PLoS Pathogens

Cellular and molecular mechanisms of viral infection in the human placenta

(2017) Moises León-Juárez et al.   Pathogens and Disease

Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection

(2017) Erica L. McGrath et al.   Stem Cell Reports

Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy

(2017) Suan-Sin Foo et al.   Nature Microbiology

Understanding the Pathogenesis of Zika Virus Infection Using Animal Models

(2017) Keeton K. Krause et al.   Immune Network

Ebola virus disease and pregnancy: A review of the current knowledge of Ebola virus pathogenesis, maternal, and neonatal outcomes

(2017) Lisa M. Bebell et al.   Birth Defects Research

The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis

(2016) Amanda L. Prince et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Zika Virus Infects Human Placental Macrophages

(2016) Kendra M. Quicke et al.   Cell Host & Microbe

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

(2016) Avraham Bayer et al.   Cell Host & Microbe

Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission

(2016) Takako Tabata et al.   Cell Host & Microbe

Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study

(2016) Simon Cauchemez et al.   LANCET

Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study

(2016) Guilherme Calvet et al.   LANCET INFECTIOUS DISEASES

Zika Virus Infection in Pregnant Women in Rio de Janeiro

(2016) Patrícia Brasil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika and the Risk of Microcephaly

(2016) Michael A. Johansson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity

(2016) Yingshi Ouyang et al.   PLACENTA

Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?

(2016) A. S. Oliveira Melo et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Gene expression profiling of rubella virus infected primary endothelial cells of fetal and adult origin

(2016) Henriette Geyer et al.   Virology Journal

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance

(2016) C. A. McConkey et al.   Science Advances

Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome

(2016) Mihaela Lazar et al.   EBioMedicine

Placenta-on-a-chip: a novel platform to study the biology of the human placenta

(2015) Ji Soo Lee et al.   Journal of Maternal-Fetal & Neonatal Medicine

Only humans have human placentas: molecular differences between mice and humans

(2015) André Schmidt et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Proliferation control in neural stem and progenitor cells

(2015) Catarina C. F. Homem et al.   NATURE REVIEWS NEUROSCIENCE

Ebola Virus Disease and Marburg Disease in Pregnancy

(2015) Lisa M. Bebell et al.   OBSTETRICS AND GYNECOLOGY

Pregnancy Loss Following Coxsackievirus B3 Infection in Mice during Early Gestation Due toHigh Expression of Coxsackievirus-Adenovirus Receptor (CAR) in Uterus and Embryo

(2014) Ji Young Hwang et al.   EXPERIMENTAL ANIMALS

Bacteria Localization and Chorion Thinning among Preterm Premature Rupture of Membranes

(2014) Kimberly B. Fortner et al.   PLoS One

Normal Human Pregnancy Results in Maternal Immune Activation in the Periphery and at the Uteroplacental Interface

(2014) Andrea I. Loewendorf et al.   PLoS One

The Placenta Harbors a Unique Microbiome

(2014) K. Aagaard et al.   Science Translational Medicine

Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea

(2014) Jung Hye Hwang et al.   YONSEI MEDICAL JOURNAL

A Comparison of the Histological Structure of the Placenta in Experimental Animals

(2014) Satoshi Furukawa et al.   Journal of Toxicologic Pathology

Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations

(2013) Molly J. Stout et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Review: Placenta-specific microRNAs in exosomes – Good things come in nano-packages

(2013) Y. Ouyang et al.   PLACENTA

Human placental trophoblasts confer viral resistance to recipient cells

(2013) E. Delorme-Axford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis

(2012) Dionne P. Robinson et al.   HORMONES AND BEHAVIOR

The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes

(2012) R. B. Donker et al.   MOLECULAR HUMAN REPRODUCTION

The guinea pig as an animal model for studying perinatal changes in microvascular function

(2012) Rebecca M. Dyson et al.   PEDIATRIC RESEARCH

Placental Hofbauer cells limit HIV-1 replication and potentially offset mother to child transmission (MTCT) by induction of immunoregulatory cytokines

(2012) Erica L Johnson et al.   Retrovirology

Phenotypic and Functional Characterization of Mesenchymal Stem Cells from Chorionic Villi of Human Term Placenta

(2012) M. H. Abumaree et al.   Stem Cell Reviews and Reports

Human placenta-derived mesenchymal stem cells suppress T cell proliferation and support the culture expansion of cord blood CD34+ cells: A comparison with human bone marrow-derived mesenchymal stem cells

(2012) Xiying Luan et al.   TISSUE & CELL

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age

(2011) Gisela Enders et al.   JOURNAL OF CLINICAL VIROLOGY

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

(2011) Anthony M Carter   REPRODUCTION

Maternal Immune Responses to Trophoblast: The Contribution of the Horse to Pregnancy Immunology

(2010) Leela E. Noronha et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta

(2010) M. Noguer-Dance et al.   HUMAN MOLECULAR GENETICS

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions

(2010) Jennifer Barrila et al.   NATURE REVIEWS MICROBIOLOGY

Characterisation of Hofbauer Cells in First and Second Trimester Placenta: Incidence, Phenotype, Survival in vitro and Motility

(2010) K. Ingman et al.   PLACENTA

Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes1

(2009) Shan-Shun Luo et al.   BIOLOGY OF REPRODUCTION

C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts

(2009) M.-L. Bortolin-Cavaille et al.   NUCLEIC ACIDS RESEARCH

Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention

(2009) Elena Anzivino et al.   Virology Journal

Glial Cells Missing Homologue 1 Is Induced in Differentiating Equine Chorionic Girdle Trophoblast Cells1

(2008) Amanda M. de Mestre et al.   BIOLOGY OF REPRODUCTION

Placental endothelial cells can be productively infected by Parvovirus B19

(2008) Gianandrea Pasquinelli et al.   JOURNAL OF CLINICAL VIROLOGY