CDK12: A Potent Target and Biomarker for Human Cancer Therapy

Heterogeneity of genomic profile in patients with HER2-positive breast cancer

(2020) Bo Chen et al.   ENDOCRINE-RELATED CANCER

Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy

(2020) Jonathan Chou et al.   Cancer Discovery

CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition

(2020) Martina S.J. McDermott et al.   Cells

Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery

(2020) Alberto Pérez-Posada et al.   PLoS Genetics

Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer

(2019) Judit Castillo et al.   MOLECULAR & CELLULAR PROTEOMICS

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability

(2019) Seung H. Choi et al.   GENES & DEVELOPMENT

CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes

(2019) Anil Paul Chirackal Manavalan et al.   EMBO REPORTS

Pan‐Cancer Analysis of CDK12 Loss‐of‐Function Alterations and Their Association with the Focal Tandem‐Duplicator Phenotype

(2019) Ethan S. Sokol et al.   ONCOLOGIST

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

(2019) Malgorzata Krajewska et al.   Nature Communications

A Splice Site Variant of CDK12 and Breast Cancer in Three Eurasian Populations

(2019) Natalia V. Bogdanova et al.   Frontiers in Oncology

CDK 12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS 1‐ErbB‐ PI 3K signaling

(2019) Hee‐Joo Choi et al.   EMBO REPORTS

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma

(2019) Cun Wang et al.   GUT

Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma

(2019) Ian Bayles et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

(2019) Victor Quereda et al.   CANCER CELL

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

(2019) Arun Kanakkanthara et al.   CANCER RESEARCH

CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β-catenin Signaling

(2019) Fang Peng et al.   CURRENT CANCER DRUG TARGETS

Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer

(2019) Melissa A. Reimers et al.   EUROPEAN UROLOGY

Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma

(2019) Meijuan Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genomics of lethal prostate cancer at diagnosis and castration resistance

(2019) Joaquin Mateo et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole-genome sequencing of prostate cancer reveals novel mutation-driven processes and molecular subgroups

(2019) Caixia Liang et al.   LIFE SCIENCES

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile

(2018) Eva Novotná et al.   ARCHIVES OF TOXICOLOGY

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

(2018) Amanda Balboni Iniguez et al.   CANCER CELL

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

(2018) Francesca Menghi et al.   CANCER CELL

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer

(2018) Yi-Mi Wu et al.   CELL

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

(2018) David A. Quigley et al.   CELL

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

(2018) Srinivas R. Viswanathan et al.   CELL

Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation

(2018) Tingjun Lei et al.   Nature Communications

Metastatic and triple-negative breast cancer: challenges and treatment options

(2018) Sumayah Al-Mahmood et al.   Drug Delivery and Translational Research

CDK12: an emerging therapeutic target for cancer

(2018) Goldie Y L Lui et al.   JOURNAL OF CLINICAL PATHOLOGY

Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis

(2018) Chenfei Zhou et al.   Cancer Management and Research

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation

(2018) Sara J. Dubbury et al.   NATURE

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

(2018) Mei Zeng et al.   eLife

Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer

(2017) Sabrina Schecher et al.   INTERNATIONAL JOURNAL OF CANCER

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response–Targeted Therapies in Breast Cancer

(2017) Kalnisha Naidoo et al.   MOLECULAR CANCER THERAPEUTICS

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

(2017) Jerry F. Tien et al.   NUCLEIC ACIDS RESEARCH

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors

(2017) Hana Paculová et al.   TUMOR BIOLOGY

The emerging roles of CDK12 in tumorigenesis

(2017) Hana Paculová et al.   Cell Division

Role and therapeutic potential of CDK12 in human cancers

(2016) Rosaria Chilà et al.   CANCER TREATMENT REVIEWS

Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex

(2016) Hong-Ru Chen et al.   CEREBRAL CORTEX

Identification and Characterization of theCyclin-Dependent KinasesGene Family in Silkworm,Bombyx mori

(2016) Yinü Li et al.   DNA AND CELL BIOLOGY

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

(2016) Tinghu Zhang et al.   Nature Chemical Biology

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

(2016) Ann Katrin Greifenberg et al.   Cell Reports

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

(2016) Shawn F. Johnson et al.   Cell Reports

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

(2015) Kaiwei Liang et al.   MOLECULAR AND CELLULAR BIOLOGY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

(2015) Kingsley M. Ekumi et al.   NUCLEIC ACIDS RESEARCH

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

(2014) Nicolò Riggi et al.   CANCER CELL

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

(2014) L. Davidson et al.   GENES & DEVELOPMENT

Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS Transcripts

(2014) Tristan T. Eifler et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

The structure and substrate specificity of human Cdk12/Cyclin K

(2014) Christian A. Bösken et al.   Nature Communications

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design

(2013) Ruth Thompson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code

(2013) Dirk Eick et al.   CHEMICAL REVIEWS

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells

(2013) C Delehouzé et al.   ONCOGENE

The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity

(2012) F. Rodrigues et al.   DEVELOPMENT

Cyclin K-containing Kinase Complexes Maintain Self-renewal in Murine Embryonic Stem Cells

(2012) Qian Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models

(2012) Cynthia X. Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II

(2012) S.- W. G. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin K goes with Cdk12 and Cdk13

(2012) Jiri Kohoutek et al.   Cell Division

Dual Roles of PARP-1 Promote Cancer Growth and Progression

(2012) M. J. Schiewer et al.   Cancer Discovery

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening

(2011) T. J. Guzi et al.   MOLECULAR CANCER THERAPEUTICS

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

(2010) David Parry et al.   MOLECULAR CANCER THERAPEUTICS

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Defining mechanisms that regulate RNA polymerase II transcription in vivo

(2009) Nicholas J. Fuda et al.   NATURE

Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron

(2008) Donald J Messner et al.   BMC GASTROENTEROLOGY

The SH3 domain- a family of versatile peptide- and protein-recognition module

(2008) Tomonori Kaneko   Frontiers in Bioscience-Landmark

Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma

(2008) Ines Gütgemann et al.   MODERN PATHOLOGY

Cracking the RNA polymerase II CTD code

(2008) Sylvain Egloff et al.   TRENDS IN GENETICS