Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

(2014) L. Davidson et al.   GENES & DEVELOPMENT

Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors

(2014) Poorval M. Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

(2014) Rachael Natrajan et al.   JOURNAL OF PATHOLOGY

Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS Transcripts

(2014) Tristan T. Eifler et al.   MOLECULAR AND CELLULAR BIOLOGY

The structure and substrate specificity of human Cdk12/Cyclin K

(2014) Christian A. Bösken et al.   Nature Communications

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

(2014) Xiaodan Ji et al.   eLife

Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity

(2013) I. Bajrami et al.   CANCER RESEARCH

Transcriptional Regulation and Its Misregulation in Disease

(2013) Tong Ihn Lee et al.   CELL

The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code

(2013) Dirk Eick et al.   CHEMICAL REVIEWS

A DNA Damage Response System Associated with the phosphoCTD of Elongating RNA Polymerase II

(2013) Tiffany Sabin Winsor et al.   PLoS One

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

The cyclin K/Cdk12 complex

(2012) Dalibor Blazek   CELL CYCLE

Cyclin K-containing Kinase Complexes Maintain Self-renewal in Murine Embryonic Stem Cells

(2012) Qian Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II

(2012) S.- W. G. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene-specific requirement of RNA polymerase II CTD phosphorylation

(2012) Julie Drogat et al.   MOLECULAR MICROBIOLOGY

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cyclin K goes with Cdk12 and Cdk13

(2012) Jiri Kohoutek et al.   Cell Division

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

The super elongation complex (SEC) and MLL in development and disease

(2011) E. Smith et al.   GENES & DEVELOPMENT

Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

(2011) Tina Lenasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Genome profiling of ERBB2-amplified breast cancers

(2010) Fabrice Sircoulomb et al.   BMC CANCER

Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

(2010) Z. J. Zang et al.   CANCER RESEARCH

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

A Gene-Specific Requirement of RNA Polymerase II CTD Phosphorylation for Sexual Differentiation in S. pombe

(2010) Damien Coudreuse et al.   CURRENT BIOLOGY

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

(2010) Brenda C. O'Connell et al.   MOLECULAR CELL

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

P-TEFb stimulates transcription elongation and pre-mRNA splicing through multilateral mechanisms

(2010) Tina Lenasi et al.   RNA Biology

Defining mechanisms that regulate RNA polymerase II transcription in vivo

(2009) Nicholas J. Fuda et al.   NATURE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE