Role of EGFR in the Nervous System

Alteration of the late endocytic pathway in Charcot–Marie–Tooth type 2B disease

(2020) Roberta Romano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation

(2020) Paola Saveri et al.   Cells

A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy

(2020) Adileh Ayati et al.   BIOORGANIC CHEMISTRY

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation

(2019) Sarah C. Starossom et al.   Nature Communications

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

(2019) Tai L. Ng et al.   NATURE

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

(2019) Pilar Rivero-Ríos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte‐to‐astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation

(2019) Jiwen Li et al.   GLIA

Mechanisms of ERBB3 Action in Human Neoplasia

(2019) Laurel Black et al.   AMERICAN JOURNAL OF PATHOLOGY

Myelin in the Central Nervous System: Structure, Function, and Pathology

(2019) Christine Stadelmann et al.   PHYSIOLOGICAL REVIEWS

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

(2019) James W. Fawcett   NEUROCHEMICAL RESEARCH

EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP

(2019) Emanuela Nocita et al.   Cells

Neural stem cell therapy - brief review

(2018) Cezary Grochowski et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain

(2018) Jonathan P. Robson et al.   FEBS Journal

Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury

(2018) Su-Mei Liu et al.   CNS Neuroscience & Therapeutics

Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development

(2018) Qian Yang et al.   Frontiers in Molecular Neuroscience

The EGFR odyssey – from activation to destruction in space and time

(2017) Jeroen Bakker et al.   JOURNAL OF CELL SCIENCE

Epiregulin and EGFR interactions are involved in pain processing

(2017) Loren J. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging functions of the EGFR in cancer

(2017) Sara Sigismund et al.   Molecular Oncology

EGF Enhances Oligodendrogenesis from Glial Progenitor Cells

(2017) Junlin Yang et al.   Frontiers in Molecular Neuroscience

Inhibition of Epidermal Growth Factor Receptor Improves Myelination and Attenuates Tissue Damage of Spinal Cord Injury

(2016) Si Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Necdin controls EGFR signaling linked to astrocyte differentiation in primary cortical progenitor cells

(2016) Izumi Fujimoto et al.   CELLULAR SIGNALLING

Analysis of genetics and risk factors of Alzheimer’s Disease

(2016) M. Panpalli Ates et al.   NEUROSCIENCE

Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease

(2016) Jianchun Chen et al.   PHYSIOLOGICAL REVIEWS

Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

(2015) Julien Bruban et al.   FASEB JOURNAL

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway

(2015) Apichaya Niyomchan et al.   TOXICOLOGY LETTERS

EGFR signaling patterns are regulated by its different ligands

(2014) Stine Louise Jeppe Knudsen et al.   GROWTH FACTORS

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury

(2014) Zai-Wang Li et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The mechanisms of EGFR in the regulation of axon regeneration

(2013) Ming-Feng Xu et al.   CELL BIOCHEMISTRY AND FUNCTION

Tissue kallikrein mediates neurite outgrowth through epidermal growth factor receptor and flotillin-2 pathway in vitro

(2013) Zhengyu Lu et al.   CELLULAR SIGNALLING

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on  -Secretase Activity and A  Production

(2013) E. A. Heilig et al.   JOURNAL OF NEUROSCIENCE

Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension

(2013) T. S. Pavlov et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intranasal epidermal growth factor treatment rescues neonatal brain injury

(2013) Joseph Scafidi et al.   NATURE

EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS

(2013) Claire E. Le Pichon et al.   PLoS One

ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease

(2013) Yuriko Iwakura et al.   Frontiers in Cellular Neuroscience

Reduced EGFR level potentially mediates the Aβ42-induced neuronal loss in transgenic fruit fly and mouse

(2013) Lei Wang et al.   Protein & Cell

ErbB1 epidermal growth factor receptor is a valid target for reducing the effects of multiple inhibitors of axonal regeneration

(2012) Veronica H.L. Leinster et al.   EXPERIMENTAL NEUROLOGY

Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury

(2012) Peijun Ju et al.   GLIA

Local generation of glia is a major astrocyte source in postnatal cortex

(2012) Woo-Ping Ge et al.   NATURE

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

(2012) Gael Barthet et al.   NEUROBIOLOGY OF AGING

Epidermal growth factor receptor is a preferred target for treating Amyloid- -induced memory loss

(2012) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

(2012) Gael Barthet et al.   PROGRESS IN NEUROBIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Glial cells in adult neurogenesis

(2011) Joachim Morrens et al.   GLIA

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

(2011) Radek Dobrowolski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SHP-2 Promotes the Maturation of Oligodendrocyte Precursor Cells Through Akt and ERK1/2 Signaling In Vitro

(2011) Xiujie Liu et al.   PLoS One

Subventricular zone microglia transcriptional networks

(2010) Sarah C. Starossom et al.   BRAIN BEHAVIOR AND IMMUNITY

Epidermal growth factor receptor antagonists and CNS axon regeneration: Mechanisms and controversies

(2010) Martin Berry et al.   BRAIN RESEARCH BULLETIN

Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase

(2010) Ying Zhu et al.   GLIA

A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity

(2010) Elizabeth A. Heilig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development

(2010) Emory Kuo et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

(2010) Adan Aguirre et al.   NATURE

Satellite glia not DRG neurons constitutively activate EGFR but EGFR inactivation is not correlated with axon regeneration

(2010) Zubair Ahmed et al.   NEUROBIOLOGY OF DISEASE

Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice

(2010) Mary Wines-Samuelson et al.   PLoS One

PI3 kinase signaling is involved in A -induced memory loss in Drosophila

(2010) H.-C. Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth

(2009) Michael R. Douglas et al.   BRAIN

Epidermal Growth Factor (EGF) Promotes the In Vitro Differentiation of Neural Crest Cells to Neurons and Melanocytes

(2009) Ricardo Castilho Garcez et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR

(2009) M. E. Evangelopoulos et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia

(2009) Zubair Ahmed et al.   NEUROBIOLOGY OF DISEASE

Epidermal Growth Factor Induces the Progeny of Subventricular Zone Type B Cells to Migrate and Differentiate into Oligodendrocytes

(2009) Oscar Gonzalez-Perez et al.   STEM CELLS

Characterization of the Rab7K157N mutant protein associated with Charcot–Marie-Tooth type 2B

(2008) Azzurra De Luca et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Persistent inflammation alters the function of the endogenous brain stem cell compartment

(2008) Stefano Pluchino et al.   BRAIN

Nf1 Mutation Expands an EGFR-Dependent Peripheral Nerve Progenitor that Confers Neurofibroma Tumorigenic Potential

(2008) Jon P. Williams et al.   Cell Stem Cell

Stem Cells for Spinal Cord Repair

(2008) Fanie Barnabé-Heider et al.   Cell Stem Cell

The epidermal growth factor receptor ligands at a glance

(2008) Marlon R. Schneider et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The EGFR Is Required for Proper Innervation to the Skin

(2008) Adel Maklad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spinal Cord mRNA Profile in Patients with ALS: Comparison with Transgenic Mice Expressing the Human SOD-1 Mutant

(2008) Daniel Offen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Constitutive EGFR Signaling in Oligodendrocyte Progenitors Leads to Diffuse Hyperplasia in Postnatal White Matter

(2008) S. Ivkovic et al.   JOURNAL OF NEUROSCIENCE

Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease

(2008) M. R. Spinosa et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE