Engineering a Humanised Niche to Support Human Haematopoiesis in Mice: Novel Opportunities in Modelling Cancer

Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease

(2019) Huan Liu et al.   Science Translational Medicine

Development, regulation, metabolism and function of bone marrow adipose tissues

(2018) Ziru Li et al.   BONE

The adipose organ and multiple myeloma: Impact of adipokines on tumor growth and potential sites for therapeutic intervention

(2018) Alessandro Allegra et al.   European Journal of Internal Medicine

Rational Design of Mouse Models for Cancer Research

(2018) Marietta Landgraf et al.   TRENDS IN BIOTECHNOLOGY

The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer

(2018) Mayra A. Carrillo et al.   Frontiers in Immunology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

(2017) Ander Abarrategi et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering a humanized bone organ model in mice to study bone metastases

(2017) Laure C Martine et al.   Nature Protocols

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

(2017) Diana Passaro et al.   Jove-Journal of Visualized Experiments

Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo

(2017) Yoshihito Minoda et al.   Frontiers in Immunology

In Vivo Murine-Matured Human CD3 + Cells as a Preclinical Model for T Cell-Based Immunotherapies

(2017) Kevin G. Haworth et al.   Molecular Therapy-Methods & Clinical Development

A Validated Preclinical Animal Model for Primary Bone Tumor Research

(2016) Ferdinand Wagner et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Phase II and phase III failures: 2013–2015

(2016) Richard K. Harrison   NATURE REVIEWS DRUG DISCOVERY

Tissue engineered humanized bone supports human hematopoiesis in vivo

(2015) Boris M. Holzapfel et al.   BIOMATERIALS

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Navigating the bone marrow niche: translational insights and cancer-driven dysfunction

(2015) Michaela R. Reagan et al.   Nature Reviews Rheumatology

Concise Review: Humanized Models of Tumor Immunology in the 21st Century: Convergence of Cancer Research and Tissue Engineering

(2015) Boris Michael Holzapfel et al.   STEM CELLS

HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide

(2015) Alessandro Canella et al.   Oncotarget

Modifications of the mouse bone marrow microenvironment favor angiogenesis and correlate with disease progression from asymptomatic to symptomatic multiple myeloma

(2015) Arianna Calcinotto et al.   OncoImmunology

Mimicking breast cancer-induced bone metastasis in vivo: current transplantation models and advanced humanized strategies

(2014) Laure Thibaudeau et al.   CANCER AND METASTASIS REVIEWS

Differences in innate immune response between man and mouse

(2014) Josefin Zschaler et al.   CRITICAL REVIEWS IN IMMUNOLOGY

A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone

(2014) L. Thibaudeau et al.   Disease Models & Mechanisms

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients

(2014) Melanie Werner-Klein et al.   PLoS One

The role of epigenetics in the biology of multiple myeloma

(2014) K Dimopoulos et al.   Blood Cancer Journal

Effect of culture conditions and calcium phosphate coating on ectopic bone formation

(2013) Cédryck Vaquette et al.   BIOMATERIALS

Signaling Between Tumor Cells and the Host Bone Marrow Microenvironment

(2013) Natasa Kovacic et al.   CALCIFIED TISSUE INTERNATIONAL

Humanised xenograft models of bone metastasis revisited: novel insights into species-specific mechanisms of cancer cell osteotropism

(2013) Boris Michael Holzapfel et al.   CANCER AND METASTASIS REVIEWS

Design and Fabrication of Tubular Scaffolds via Direct Writing in a Melt Electrospinning Mode

(2012) Toby D. Brown et al.   Biointerphases

Multiple myeloma-related deregulation of bone marrow-derived CD34+ hematopoietic stem and progenitor cells

(2012) I. Bruns et al.   BLOOD

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

(2012) R. W. J. Groen et al.   BLOOD

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

(2012) Y. Chen et al.   BLOOD

Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγnull Mice Display a T-Effector Memory Phenotype

(2012) Niwa Ali et al.   PLoS One

A Novel Mouse Model for Multiple Myeloma (MOPC315.BM) That Allows Noninvasive Spatiotemporal Detection of Osteolytic Disease

(2012) Peter O. Hofgaard et al.   PLoS One

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

(2012) J E Noll et al.   Blood Cancer Journal

A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells

(2011) T Calimeri et al.   LEUKEMIA

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment

(2010) Johannes C. Reichert et al.   BIOMATERIALS

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

(2010) J. Hu et al.   BLOOD

Denosumab and bisphosphonates: Different mechanisms of action and effects

(2010) Roland Baron et al.   BONE

Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis

(2010) Arun Balakumaran et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

(2009) M. Fulciniti et al.   BLOOD

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY