Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy

The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo

(2020) Salome Paillas et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase

(2019) Ming-Jen Lee et al.   PHYTOMEDICINE

The transcriptional regulator Sin3A contributes to the oncogenic potential of STAT3

(2019) Giovanni Gambi et al.   CANCER RESEARCH

Sp1‐mediated epigenetic dysregulation dictates HDAC inhibitor susceptibility of HER2‐overexpressing breast cancer

(2019) Guoyin Li et al.   INTERNATIONAL JOURNAL OF CANCER

Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy

(2019) Debarati Banik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

(2019) Min-Wu Chao et al.   Clinical Epigenetics

Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines

(2019) Jan J. Bandolik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma

(2019) Giada Juli et al.   Cancers

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

(2019) Baoyuan Zhang et al.   Acta Pharmaceutica Sinica B

Suppression of BCL6 function by HDAC inhibitor mediated acetylation and chromatin modification enhances BET inhibitor effects in B-cell lymphoma cells

(2019) María G. Cortiguera et al.   Scientific Reports

Vorinostat and Belinostat, hydroxamate-based anti-cancer agents, are nitric oxide donors

(2019) Reece G. Kenny et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Phase II Trial of Bortezomib and Vorinostat in Mantle Cell Lymphoma and Diffuse Large B-cell Lymphoma

(2018) Victor Yazbeck et al.   Clinical Lymphoma Myeloma & Leukemia

Curcumin: A Natural Pan-HDAC Inhibitor in Cancer

(2018) Sara Saffar Soflaei et al.   CURRENT PHARMACEUTICAL DESIGN

Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms

(2018) Ashlesha Chaubal et al.   Epigenetics & Chromatin

Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

(2018) Johannes Ridinger et al.   Scientific Reports

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo

(2018) R. D. W. Kelly et al.   Scientific Reports

The Enzyme Activity of Histone Deacetylase 8 is Modulated by a Redox-Switch

(2018) Niklas Jänsch et al.   Redox Biology

Elevated histone H3 acetylation and loss of the Sp1–HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma

(2018) Avisek Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysine acetylation and cancer: A proteomics perspective

(2017) Jeovanis Gil et al.   Journal of Proteomics

Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity

(2017) Blaz Groselj et al.   MOLECULAR CANCER THERAPEUTICS

Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers

(2017) Gilson J Sanchez et al.   NUCLEIC ACIDS RESEARCH

Targeting Class I Histone Deacetylases in a “Complex” Environment

(2017) Christopher J. Millard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids

(2017) Júlia Novaes et al.   Pharmaceutics

Phase II multicenter trial of the histone deactylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed epithelial ovarian cancer (EOC)

(2017) N. J. Finkler et al.   JOURNAL OF CLINICAL ONCOLOGY

Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45-NER pathway

(2016) Pallavi Rajput et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

(2016) Seung Ho Baek et al.   PHYTOMEDICINE

The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

(2016) Øystein Helland et al.   PLoS One

The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7

(2016) Jason W. Schmidberger et al.   PROTEIN SCIENCE

Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms

(2016) Dona Sinha et al.   SEMINARS IN CANCER BIOLOGY

Exploring the molecular targets of dietary flavonoid fisetin in cancer

(2016) Deeba N. Syed et al.   SEMINARS IN CANCER BIOLOGY

Calebin-A induces cell cycle arrest in human colon cancer cells and xenografts in nude mice

(2016) Wen-Shiung Liou et al.   Journal of Functional Foods

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

(2016) Elizabeth E. Hull et al.   Biomed Research International

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

(2016) Hannah Wapenaar et al.   Clinical Epigenetics

The structure of the core NuRD repression complex provides insights into its interaction with chromatin

(2016) Christopher J Millard et al.   eLife

Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor

(2015) Jingwei Zhou et al.   ACS Chemical Biology

Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1

(2015) Yue Guo et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer

(2015) Swati Dhar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emerging roles of lysine methylation on non-histone proteins

(2015) Xi Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure and function insights into the NuRD chromatin remodeling complex

(2015) Morgan P. Torchy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells

(2015) Khushwant S. Bhullar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Natural and Synthetic Flavonoids: Structure–Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia

(2015) José C. J. M. D. S. Menezes et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Calebin A: Analytical Development for Pharmacokinetics Study, Elucidation of Pharmacological Activities and Content Analysis of Natural Health Products

(2015) Ana Luísa De P. Oliveira et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Expression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanoma

(2015) James S Wilmott et al.   MODERN PATHOLOGY

HDAC inhibitors still need a home run, despite recent approval

(2015) Malini Guha   NATURE REVIEWS DRUG DISCOVERY

Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity

(2015) Shu-Huei Wang et al.   PLoS One

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

(2015) I Rettig et al.   Cell Death & Disease

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

(2015) Jonas Ecker et al.   Acta Neuropathologica Communications

HDAC inhibitors and immunotherapy; a double edged sword?

(2015) Michiel Kroesen et al.   Oncotarget

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

(2014) M. Bots et al.   BLOOD

Suberoylanilide hydroxamic acid suppresses inflammation-induced neovascularization

(2014) Hongyan Zhou et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention

(2014) Samriddhi Shukla et al.   CANCER LETTERS

Crafting the Brain – Role of Histone Acetyltransferases in Neural Development and Disease

(2014) Bilal N. Sheikh   CELL AND TISSUE RESEARCH

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner

(2014) Rodrigo L. dos Santos et al.   Cell Stem Cell

Function of transcription factors at DNA lesions in DNA repair

(2014) Michal Malewicz et al.   EXPERIMENTAL CELL RESEARCH

Curcumin Augments the Efficacy of Antitumor Drugs Used in Leukemia by Modulation of Heat Shock Proteins Via HDAC6

(2014) Ruma Sarkar et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

(2014) Bharat Aggarwal et al.   MOLECULES

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

(2013) Richard D.W. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

(2013) O. M. Dovey et al.   BLOOD

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

(2013) F. Santoro et al.   BLOOD

Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

(2013) Berit Maria Müller et al.   BMC CANCER

Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class Ι histone deacetylases

(2013) Chi-qi Chen et al.   CARCINOGENESIS

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

(2013) Rachel Deplus et al.   EMBO JOURNAL

An Update on Antitumor Activity of Naturally Occurring Chalcones

(2013) En-Hui Zhang et al.   Evidence-based Complementary and Alternative Medicine

Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression

(2013) Chenlin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase Ib Study of Panobinostat and Bortezomib in Relapsed or Relapsed and Refractory Multiple Myeloma

(2013) Jesús F. San-Miguel et al.   JOURNAL OF CLINICAL ONCOLOGY

Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi-1 leukemia cells

(2013) ZHI-HUA ZHANG et al.   Molecular Medicine Reports

Curcumin as a regulator of epigenetic events

(2013) Marie-Hélène Teiten et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Histone chaperones in nucleosome assembly and human disease

(2013) Rebecca J Burgess et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correction: Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells

(2013) Sascha Venturelli et al.   PLoS One

HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses

(2013) J E Bolden et al.   Cell Death & Disease

Health-Promoting Components of Fruits and Vegetables in the Diet

(2013) Rui Hai Liu   Advances in Nutrition

Synthesis of Biologically Active Chalcones and their Anti-inflammatory Effects

(2012) Jae-Ho Jeon et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Sp1 Facilitates DNA Double-Strand Break Repair through a Nontranscriptional Mechanism

(2012) K. Beishline et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

Synthesis of Chalcones with Anticancer Activities

(2012) Suvitha Syam et al.   MOLECULES

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics

(2012) Arne H. Smits et al.   NUCLEIC ACIDS RESEARCH

Histone Deacetylase in Chronic Lymphocytic Leukemia

(2012) J.C. Wang et al.   ONCOLOGY

Natural chalcones as dual inhibitors of HDACs and NF-κB

(2012) B. ORLIKOVA et al.   ONCOLOGY REPORTS

Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells

(2011) Limin Shu et al.   AAPS Journal

Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors

(2011) Srinivas Kantevari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Histone Deacetylases 9 and 10 Are Required for Homologous Recombination

(2011) Shweta Kotian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Histone Deacetylase 11 Promotes Expression of IL-10 in Kupffer Cells and Induces Tolerance Following Orthotopic Liver Transplantation in Rats

(2011) Zheng-rong Lian et al.   JOURNAL OF SURGICAL RESEARCH

Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung

(2011) Yoshihiro Minamiya et al.   LUNG CANCER

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

(2011) Praveen Rajendran et al.   Molecular Cancer

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

The role of Sp1 and Sp3 in normal and cancer cell biology

(2010) Lin Li et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

research paper: Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia

(2010) Daniel Antunes Moreno et al.   BRITISH JOURNAL OF HAEMATOLOGY

Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma

(2010) Ruben Niesvizky et al.   CANCER

HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis

(2010) J.C. Morales et al.   CANCER LETTERS

Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex

(2010) Karen T. Smith et al.   CHEMISTRY & BIOLOGY

Regulatory signal transduction pathways for class IIa histone deacetylases

(2010) Maribel Parra et al.   CURRENT OPINION IN PHARMACOLOGY

Oct1 regulates trophoblast development during early mouse embryogenesis

(2010) V. Sebastiano et al.   DEVELOPMENT

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

(2010) Sabine Lagger et al.   EMBO JOURNAL

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

(2010) T. Yamaguchi et al.   GENES & DEVELOPMENT

Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabinein vitroand in orthotopic mouse model of human pancreatic cancer

(2010) Kuzhuvelil B. Harikumar et al.   INTERNATIONAL JOURNAL OF CANCER

Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin

(2010) Akiko Hayashi et al.   INTERNATIONAL JOURNAL OF CANCER

Marine Drugs from Sponge-Microbe Association—A Review

(2010) Tresa Remya A. Thomas et al.   Marine Drugs

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

(2010) Cristina Aguilera et al.   NATURE

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy

(2010) O. Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung

(2010) Yoshihiro Minamiya et al.   TUMOR BIOLOGY

Energetic Differences at the Subunit Interfaces of Normal Human Hemoglobins Correlate with Their Developmental Profile

(2009) Lois R. Manning et al.   BIOCHEMISTRY

Sin3: Master scaffold and transcriptional corepressor

(2009) Adrienne Grzenda et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies

(2009) Gamze Bora-Tatar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

(2009) Anastasia Detsi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isoform-specific histone deacetylase inhibitors: The next step?

(2009) Sriram Balasubramanian et al.   CANCER LETTERS

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

(2009) Ailsa J. Frew et al.   CANCER LETTERS

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA

(2009) P Fritsche et al.   GUT

Class IIa histone deacetylases: conducting development and differentiation

(2009) Maud Martin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A Positive Regulatory Role for the mSin3A-HDAC Complex in Pluripotency through Nanog and Sox2

(2009) Gretchen A. Baltus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma

(2009) Richard L. Piekarz et al.   JOURNAL OF CLINICAL ONCOLOGY

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model

(2009) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

(2008) Florian R Fritzsche et al.   BMC CANCER

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

(2008) W Weichert et al.   BRITISH JOURNAL OF CANCER

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

(2008) Jessica L. MacDonald et al.   DEVELOPMENTAL DYNAMICS

Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead

(2008) Antonello Mai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Novel Germ Cell-specific Protein, SHIP1, Forms a Complex with Chromatin Remodeling Activity during Spermatogenesis

(2008) Eunyoung Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Chalcone Polyphenol Inhibits the Deacetylase Activity of SIRT1 and Cell Growth in HEK293T Cells

(2008) Tomoaki Kahyo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

(2008) Yongcheng Ying et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones

(2008) Solomon S. Solomon et al.   LIFE SCIENCES

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

(2008) Agustín Valenzuela-Fernández et al.   TRENDS IN CELL BIOLOGY

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

(2008) Bharat B. Aggarwal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Developmental expression of histone deacetylase 11 in the murine brain

(2007) Hedi Liu et al.   JOURNAL OF NEUROSCIENCE RESEARCH