Article
Multidisciplinary Sciences
Ming Tang, Guofang Chen, Bo Tu, Zhiyi Hu, Yujia Huang, Christopher C. DuFort, Xiaoping Wan, Zhiyong Mao, Yongzhong Liu, Wei-Guo Zhu, Wen Lu
Summary: DDR has different effects on cancer susceptibility and drug resistance. Recent studies showed that DDR inhibitors impact immune surveillance, however, the underlying mechanism is poorly understood. This study reveals that methyltransferase SMYD2 plays a crucial role in nonhomologous end joining repair (NHEJ), promoting tumor cell adaptability to radiotherapy. SMYD2 is mobilized to chromatin upon DNA damage and methylates Ku70, leading to increased recruitment of Ku70/Ku80/DNA-PKcs complex. Inhibition of SMYD2 or knockdown of SMYD2 results in persistent DNA damage and improper repair, leading to cytosolic DNA accumulation and activation of cGAS-STING pathway, triggering antitumor immunity by infiltration and activation of cytotoxic CD8+ T cells. This study reveals a novel role of SMYD2 in regulating NHEJ pathway and innate immune responses, suggesting SMYD2 as a promising therapeutic target for cancer treatment.
Article
Biochemistry & Molecular Biology
Chirada Dusadeemeelap, Thira Rojasawasthien, Takuma Matsubara, Shoichiro Kokabu, William N. Addison
Summary: This study investigates the role of TET-mediated DNA hydroxymethylation in bone formation using a novel selective TET enzyme inhibitor, BC339. The results show that inhibiting TET with BC339 suppresses osteoblast differentiation and functions through increasing the methylation level of the Sp7 promoter.
Editorial Material
Oncology
Antoine Italiano
Summary: In a phase I trial, Yap and colleagues found that the ATR inhibitor BAY 1895344 is safe and induces durable responses in ATM-deficient tumors. This opens up possibilities for innovative combination regimens targeting DNA damage response defects in cancer.
Article
Oncology
Yucheng Liu, Xinyan Wang, Wucheng Zhu, Zhongheng Sui, Xiangqing Wei, Yang Zhang, Jiansong Qi, Yanhong Xing, Wuyang Wang
Summary: This study reveals the mechanism by which TRPML1 inhibits autophagy to regulate apoptosis, involving disrupted mitochondrial turnover, elevated ROS, DNA damage, and p53 activation. These findings have potential clinical implications for treating melanoma and glioblastoma.
Article
Oncology
Johanna Vollmer, Jonas Ecker, Thomas Hielscher, Gintvile Valinciute, Johannes Ridinger, Nora Jamaladdin, Heike Peterziel, Cornelis M. van Tilburg, Ina Oehme, Olaf Witt, Till Milde
Summary: This study characterizes the transcriptional effects of class I HDAC inhibitors in MYC-driven medulloblastoma (MB) and explores beneficial drug combinations. The combination of entinostat with olaparib showed synergy in MYC-amplified MB cells, increasing cell death, decreasing viability, and enhancing DNA damage.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Changyong Wu, Yang Shen, Lin Shi, Junhao Zhang, Tongxuan Guo, Lingni Zhou, Wanzhou Wang, Xu Zhang, Rutong Yu, Xuejiao Liu
Summary: Glioblastoma multiforme (GBM) is a highly deadly brain tumor. UBA1 inhibition by TAK-243 can increase the sensitivity of GBM to radiotherapy by impairing DNA double-strand break repair. This study provides a new therapeutic strategy for improving the radiation sensitivity of GBM and lays a foundation for further clinical trials.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dehua Lu, Lailiang Qu, Cheng Wang, Heng Luo, Shang Li, Fucheng Yin, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Wan Peng, Limei Ji, Lingyi Kong, Xiaobing Wang
Summary: Combining HDAC inhibitors with DNA damage agents has shown promise in treating solid tumors. We designed a series of harmine-based inhibitors, with compound 27 showing potential in binding to DNA and causing DNA damage. Compound 27 induced cell apoptosis through the p53 signaling pathway and exhibited significant anti-proliferation effects against HCT-116 cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hongjin Chen, Yuchen Jiang, Rongdiao Liu, Jie Deng, Qinbo Chen, Lingfeng Chen, Guang Liang, Xiong Chen, Zheng Xu
Summary: Pancreatic adenocarcinoma is the deadliest type of cancer and inflammation plays a key role in its development. This study found that various inflammatory cytokines were highly expressed in pancreatic cancer, and a compound called C66, which has anti-inflammatory activity, inhibited the proliferation and migration of pancreatic cancer cells. Further investigation showed that C66 achieved this by targeting JNK and inhibiting inflammation. Knockdown of JNK expression also inhibited the proliferation and migration of pancreatic cancer cells, further confirming the role of JNK in tumor progression.
Article
Biochemistry & Molecular Biology
Yuchuan Zhou, Hongxia Liu, Wang Zheng, Qianping Chen, Songling Hu, Yan Pan, Yang Bai, Jianghong Zhang, Chunlin Shao
Summary: Through cross-analysis of different databases, this study identified 11 survival-related genes in GBM patients, with the discovery that the MMP14 gene plays a key role in SAHA-induced radiosensitization of GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Li Dong, Jianran Qin, Luyang Tai, Kangyi Mou, Xiaojun Liao, Fang Chen, Xiaosong Hu
Summary: The curcumin-mediated photodynamic technology (Cur-PDT) was found to effectively inactivate Bacillus subtilis by inducing cell redox state imbalance, damaging DNA, and disrupting membrane structures.
Article
Oncology
Bin Wei, Lingyan Xu, Wenjie Guo, Yuanyuan Wang, Jingjing Wu, Xiaofei Li, Xiaomin Cai, Jinbo Hu, Meijing Wang, Qiang Xu, Wen Liu, Yanhong Gu
Summary: SHP2 dephosphorylates PARP1 to simultaneously suppress DNA repair and enhance STING pathway-mediated antitumor immunity, suggesting SHP2 activation as a potential therapeutic approach in colon cancer. The combination of lovastatin and chemotherapy may enhance the efficacy of treatment by exacerbating STING pathway activation in tumor cells.
Article
Pharmacology & Pharmacy
Soumitra Shome, Anupam Das Talukdar, Rajat Nath, Sujit Tewari
Summary: Curcumin-ZnO nanocomposites show strong potential as an antibiofilm agent against Pseudomonas aeruginosa, inhibiting biofilm formation through increased superoxide anion generation, inhibited lipid peroxidation, and disintegration of the cell membrane.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaolei Li, Xiao Su, Rui Liu, Yongsha Pan, Jiankai Fang, Lijuan Cao, Chao Feng, Qianwen Shang, Yongjing Chen, Changshun Shao, Yufang Shi
Summary: Pharmacological modulation of macrophage phenotype by HDAC inhibitors can reshape the tumor immune microenvironment, enhance anti-tumor immune responses, and improve the efficacy of immunotherapies in various tumors.
Article
Pharmacology & Pharmacy
Xiao-Ling Liang, Lan Ouyang, Nan-Nan Yu, Zheng-Hua Sun, Zi-Kang Gui, Yu-Long Niu, Qing-Yu He, Jing Zhang, Yang Wang
Summary: This study identifies a potential anticancer therapy strategy by inducing cell death through shifting the scission position of mitochondria. The pan-HDAC inhibitor pracinostat is found to activate the CDK5-Drp1 signaling pathway, leading to mitochondrial fission and showing potential in CRC treatment.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Cell Biology
Yuan Wang, Bochao Liu, Huimei Lu, Jingmei Liu, Peter J. Romanienko, Gaetano T. Montelione, Zhiyuan Shen
Summary: This study identifies a regulatory mechanism by which the cytoplasmic function of KU70 is enabled through methylation by SETD4. Mutations of SETD4 prevent methylation of KU70. The findings also reveal the importance of SETD4 and KU70K570 methylation in the suppression of apoptosis.
Article
Oncology
Chi-Yuan Chen, Chin-Chuan Chen, Wen-Yu Chuang, Yann-Lii Leu, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh, Tong-Hong Wang
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Li-Fang Chou, Chi-Yuan Chen, Wan-Hua Yang, Chin-Chuan Chen, Junn-Liang Chang, Yann-Lii Leu, Miaw-Jene Liou, Tong-Hong Wang
Correction
Biochemistry & Molecular Biology
Ting-Hsiang Huang, Faith Fowler, Chin-Chuan Chen, Zih-Jie Shen, Barry Sleckman, Jessica K. Tyler
Article
Medical Laboratory Technology
Lin Kang, Hung-Yuan Li, Horng-Yih Ou, Pensee Wu, Shu-Huei Wang, Chih-Jen Chang, Shin-Yu Lin, Chao-Liang Wu, Hung-Tsung Wu
TRANSLATIONAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Chin-Chuan Chen, Hung-Yuan Li, Yann-Lii Leu, Yu-Ju Chen, Chia-Jen Wang, Shu-Huei Wang
Article
Medicine, General & Internal
Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Yun-Shien Lee, Jang-Hau Lian, Hsi-Lung Hsieh, Chi-Yuan Chen
Summary: The study revealed that palbociclib effectively inhibited the growth, migration, and invasion ability of OSCC cells while promoting cellular senescence and apoptosis. It was found that palbociclib induced DNA damage and p21 expression through the p53 independent pathway, leading to the downregulation of c-Myc and CDC25A expression to inhibit cell cycle progression. Additionally, palbociclib downregulated RAD51 expression to impede the DNA damage repair capability of OSCC cells.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang
Summary: Corylin induces browning of white adipocytes, activates BAT, promotes lipid metabolism, reduces body weight and fat accumulation, and increases insulin sensitivity and mitochondrial biogenesis, showing anti-obesity effects.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wei-Che Tseng, Chi-Yuan Chen, Ching-Yuh Chern, Chu-An Wang, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Yi-Tsen Kuo, Ya-Chen Chiu, Shih-Ting Tseng, Pei-Ya Lin, Shou-Jhen Liou, Yi-Chen Li, Chin-Chuan Chen
Summary: Curcumin sensitizes BRCA2-deficient cells to CPT-11 by impairing RAD52 recombinase, leading to tumor growth suppression. Additionally, curcumin combined with CPT-11 reduces the growth of BRCA2-knockout tumors in xenograft model studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chin-Chuan Chen, Chi-Yuan Chen, Shu-Fang Cheng, Tzong-Ming Shieh, Yann-Lii Leu, Wen-Yu Chuang, Kuang-Ting Liu, Shir-Hwa Ueng, Yin-Hwa Shih, Li-Fang Chou, Tong-Hong Wang
Summary: The study identified a natural compound, HGK, that can inhibit DDR in liver cancer cells and enhance their sensitivity to doxorubicin without producing any physiological toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kuo-Yen Huang, Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Hsin-Jung Li, Cai-Ling Jhong, Chi-Yuan Chen
Summary: The study revealed that quercetin could inhibit the growth of NSCLC cells harboring the EGFR C797S mutation and induce apoptosis, providing a new approach for treating this type of lung cancer.
Article
Nutrition & Dietetics
Cheng-Hsin Lin, Hung-Yuan Li, Shu-Huei Wang, Yue-Hwa Chen, Yang-Ching Chen, Hung-Tsung Wu
Summary: The study revealed that non-nutritive sweetener AceK may exacerbate dyslipidemia and atherosclerotic lesion induced by high cholesterol diet, increasing the risk of atherosclerosis.
Article
Chemistry, Medicinal
Tong-Hong Wang, Yann-Lii Leu, Chin-Chuan Chen, Hsin-Jung Li, Shuenn-Chen Yang, Kuo-Yen Huang, Chi-Yuan Chen
Summary: Psorachromene, a compound extracted from Psoralea corylifolia Linn. seeds, displays selective cytotoxic effects on NSCLC cells harboring activating EGFR mutations and inhibits activated EGFR signaling and kinase activity.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Tong-Hong Wang, Wei-Che Tseng, Yann-Lii Leu, Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu, Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen
Summary: The flavonoid corylin, isolated from Psoralea corylifolia, has been found to exhibit longevity properties in yeast, human cells, and mice. Traditional Chinese medicine has long been believed to increase lifespan, but identifying the specific molecules responsible for this effect has been challenging. Through screening traditional Chinese medicines and isolating compounds, researchers identified corylin as a key molecule in Psoralea corylifolia that extends lifespan in various organisms.
NATURE COMMUNICATIONS
(2022)