HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2

Histone Deacetylase 11 Is a Fatty-Acid Deacylase

(2018) Zsofia Kutil et al.   ACS Chemical Biology

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy

(2017) Ruan F.V. Medrano et al.   Oncotarget

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a

(2017) Hui Jing et al.   eLife

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

(2017) Xiaoyu Zhang et al.   eLife

HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine

(2016) Pornpun Aramsangtienchai et al.   ACS Chemical Biology

Identifying the functional contribution of the defatty-acylase activity of SIRT6

(2016) Xiaoyu Zhang et al.   Nature Chemical Biology

Antiviral therapy of hepatitis delta virus infection — progress and challenges towards cure

(2016) Anika Wranke et al.   Current Opinion in Virology

Sirtuins in Epigenetic Regulation

(2015) Hui Jing et al.   CHEMICAL REVIEWS

How pyridoxal 5′-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

(2015) Giorgio Giardina et al.   FEBS Journal

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

(2015) Eva Sahakian et al.   MOLECULAR IMMUNOLOGY

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

(2014) S. Bhattacharya et al.   EMBO Molecular Medicine

Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

(2014) Bin He et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses

(2013) Hui Zheng et al.   Cell Reports

Profiling of Substrates for Zinc-dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro

(2012) Andreas S. Madsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

HDAC11 is a novel drug target in carcinomas

(2012) Hedwig E. Deubzer et al.   INTERNATIONAL JOURNAL OF CANCER

HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma

(2011) D. Buglio et al.   BLOOD

The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis

(2011) Bernd C. Kieseier   CNS DRUGS

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

(2011) D. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

(2009) Donald D. Anderson et al.   PLoS One

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

(2008) Alejandro Villagra et al.   NATURE IMMUNOLOGY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY