Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells

Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance

(2018) Paula Jaime-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

(2017) Maria Ouzounova et al.   Nature Communications

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity

(2017) Maria Gato-Cañas et al.   Cell Reports

Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity

(2015) Yael Zlotnikov-Klionsky et al.   IMMUNITY

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

(2015) Inès Dufait et al.   Oncotarget

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B

(2015) Inna S. Afonina et al.   IMMUNOLOGICAL REVIEWS

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

(2015) Therese Liechtenstein et al.   Oncotarget

Granzyme B Promotes Cytotoxic Lymphocyte Transmigration via Basement Membrane Remodeling

(2014) Monica D. Prakash et al.   IMMUNITY

Location, location, location: functional and phenotypic heterogeneity between tumor-infiltrating and non-infiltrating myeloid-derived suppressor cells

(2014) Sarah K Maenhout et al.   OncoImmunology

IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation

(2013) J. J. Karrich et al.   BLOOD

Interleukin 21-Induced Granzyme B-Expressing B Cells Infiltrate Tumors and Regulate T Cells

(2013) S. Lindner et al.   CANCER RESEARCH

Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts

(2013) Sarah K. Maenhout et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis

(2013) Tao Zhang et al.   Scientific Reports

Assessing T-cell responses in anticancer immunotherapy

(2013) David Escors et al.   OncoImmunology

Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7

(2012) L. Zangi et al.   BLOOD

Granzyme B in injury, inflammation, and repair

(2012) Paul R. Hiebert et al.   TRENDS IN MOLECULAR MEDICINE

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

Granzyme B cleavage of autoantigens in autoimmunity

(2010) E Darrah et al.   CELL DEATH AND DIFFERENTIATION

Granzymes in age-related cardiovascular and pulmonary diseases

(2010) A Hendel et al.   CELL DEATH AND DIFFERENTIATION

Granzyme B as a novel factor involved in cardiovascular diseases

(2010) Yuji Saito et al.   Journal of Cardiology

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion

(2009) B. Jahrsdorfer et al.   BLOOD

Control of granzymes by serpins

(2009) D Kaiserman et al.   CELL DEATH AND DIFFERENTIATION

Granzymes and perforin in solid organ transplant rejection

(2009) J C Choy   CELL DEATH AND DIFFERENTIATION

Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion

(2009) Donatella D'Eliseo et al.   INTERNATIONAL JOURNAL OF CANCER

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of d-luciferin: effect on intensity, time kinetics and repeatability of photon emission

(2008) Marleen Keyaerts et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro

(2007) Christof Wagner et al.   MOLECULAR IMMUNOLOGY