Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration

Chronic Kidney Disease

(2020) Michael S. Goligorsky   AMERICAN JOURNAL OF PATHOLOGY

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Regulated necrosis in kidney ischemia-reperfusion injury

(2019) Aspasia Pefanis et al.   KIDNEY INTERNATIONAL

Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury

(2019) Pedro Rojas-Morales et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

Intestinal Toll-like receptor 9 deficiency leads to Paneth cell hyperplasia and exacerbates kidney, intestine, and liver injury after ischemia/reperfusion injury

(2019) Sang Jun Han et al.   KIDNEY INTERNATIONAL

NLRC5: A paradigm for NLRs in immunological and inflammatory reaction

(2019) Yuting Wu et al.   CANCER LETTERS

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

(2019) James Chapman et al.   FEBS LETTERS

Cell Death in the Kidney

(2019) Giovanna Priante et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death

(2019) Hideki Sanjo et al.   JOURNAL OF IMMUNOLOGY

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

(2019) Pengfei Xu et al.   Cell Death & Disease

TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells

(2019) Alessandra Tammaro et al.   Frontiers in Immunology

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses

(2019) Seiji Kishi et al.   JOURNAL OF CLINICAL INVESTIGATION

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

(2019) Dominick A. Matos et al.   MOLECULAR CELL

Pathophysiological Role of Organelle Stress/Crosstalk in AKI-to-CKD Transition

(2019) Hiroshi Maekawa et al.   SEMINARS IN NEPHROLOGY

The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis

(2019) Takayuki Koyano et al.   Scientific Reports

Impact of aging on transition of acute kidney injury to chronic kidney disease

(2019) Myung-Gyu Kim et al.   Scientific Reports

The global burden of kidney disease and the sustainable development goals

(2018) Valerie A Luyckx et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Oncogene-induced senescence and tumour control in complex biological systems

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth

(2018) Yi Li et al.   CELL RESEARCH

Acute Kidney Injury as a Condition of Renal Senescence

(2018) Lucia Andrade et al.   CELL TRANSPLANTATION

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H2O2-Induced NRK-52E Cells via the Nrf2/TLR4/NF-κB Pathway

(2018) Jiawei Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

(2018) Congwei Luo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury

(2018) Bing Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NLRC5 deficiency protects against acute kidney injury in mice by mediating carcinoembryonic antigen–related cell adhesion molecule 1 signaling

(2018) Quanxin Li et al.   KIDNEY INTERNATIONAL

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

The impact on quality of life of dialysis patients with renal insufficiency

(2018) Marta Dąbrowska-Bender et al.   Patient Preference and Adherence

A molecular signature for delayed graft function

(2018) Dagmara McGuinness et al.   AGING CELL

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

(2018) Ali Poyan Mehr et al.   NATURE MEDICINE

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

(2018) Hui Chen et al.   Cell Death & Disease

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

(2018) Dan E. McNamara et al.   Jove-Journal of Visualized Experiments

TREM-1 Attenuates RIPK3 Mediated Necroptosis in Hyperoxia Induced Lung Injury in Neonatal Mice

(2018) Mansoor Ali Syed et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure

(2018) Emily J. See et al.   KIDNEY INTERNATIONAL

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury

(2018) Hua-Lin Zhou et al.   NATURE

Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury

(2018) Su-Mi Kim et al.   Frontiers in Immunology

Danger signals in regulating the immune response to solid organ transplantation

(2017) Jamie L. Todd et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

(2017) Geurt Stokman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

(2017) Radmila Micanovic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

(2017) Hazel H. Szeto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI

(2017) Heather M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives

(2017) Alessandra Tammaro et al.   PHARMACOLOGY & THERAPEUTICS

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Cellular senescence in the aging and diseased kidney

(2017) F. A. Valentijn et al.   Journal of Cell Communication and Signaling

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Renal Aging: Causes and Consequences

(2016) Eoin D. O’Sullivan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular and Molecular Mechanisms of AKI

(2016) A. Agarwal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury

(2016) Jesper Kers et al.   SEMINARS IN NEPHROLOGY

Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation

(2016) Mark C. Dessing et al.   Scientific Reports

Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation

(2016) A. Tammaro et al.   Scientific Reports

Ferroptosis in p53-dependent oncosuppression and organismal homeostasis

(2015) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

(2015) Youssef Aachoui et al.   Cell Host & Microbe

Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

(2015) D. P. Basile et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

(2015) H. Rabb et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uromodulin, kidney function, cardiovascular disease, and mortality

(2015) Olivier Devuyst et al.   KIDNEY INTERNATIONAL

The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion

(2015) Mark C. Dessing et al.   KIDNEY INTERNATIONAL

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Mitochondria: a therapeutic target in acute kidney injury

(2015) Yu Ishimoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Toll-Like Receptor Family Polymorphisms Are Associated with Primary Renal Diseases but Not with Renal Outcomes Following Kidney Transplantation

(2015) Mark C. Dessing et al.   PLoS One

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion

(2015) Pieter J. Bakker et al.   PLoS One

Modeling-Enabled Characterization of Novel NLRX1 Ligands

(2015) Pinyi Lu et al.   PLoS One

A Tissue-Specific Role for Nlrp3 in Tubular Epithelial Repair after Renal Ischemia/Reperfusion

(2014) Pieter J. Bakker et al.   AMERICAN JOURNAL OF PATHOLOGY

NAD+ Deficiency in Age-Related Mitochondrial Dysfunction

(2014) Tomas A. Prolla et al.   Cell Metabolism

Mitochondria-targeted therapies for acute kidney injury

(2014) Luis Carlos Tábara et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Conditional Knockout of Proximal Tubule Mitofusin 2 Accelerates Recovery and Improves Survival after Renal Ischemia

(2014) J. M. Gall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor 4-Induced IL-22 Accelerates Kidney Regeneration

(2014) O. P. Kulkarni et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pattern recognition receptors and the inflammasome in kidney disease

(2014) Jaklien C. Leemans et al.   Nature Reviews Nephrology

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Early Activation of Toll-Like Receptor (TLR)-3 Initiates Kidney Injury after Ischemia and Reperfusion

(2014) Patrick Paulus et al.   PLoS One

Origin of regenerating tubular cells after acute kidney injury

(2014) K. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effect of Neutralization of the Extracellular High-Mobility Group Box 1 on Renal Ischemia-Reperfusion Injury in Miniature Swine

(2014) Kohei Miura et al.   TRANSPLANTATION

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Caspase-1: The inflammasome and beyond

(2013) Gabriel Sollberger et al.   Innate Immunity

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Dynamics in AKI to CKD Progression

(2013) G. R. Kinsey   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Non-apoptotic effects of antiapoptotic agent zVAD-fmk in renal injury

(2013) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

(2013) T. Shay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Toll-like Receptor (TLR) 2 and 9 in Renal Ischemia and Reperfusion Injury

(2013) Xingzhi Li et al.   UROLOGY

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR4 mRNA Levels as Tools to Estimate Risk for Early Posttransplantation Kidney Graft Dysfunction

(2012) Vinicius Andrade-Oliveira et al.   TRANSPLANTATION

Delayed Graft Function in the Kidney Transplant

(2011) A. Siedlecki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

RAGE Does Not Contribute to Renal Injury and Damage upon Ischemia/Reperfusion-Induced Injury

(2011) Mark C. Dessing et al.   Journal of Innate Immunity

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

(2011) H. H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Pathophysiology of ischemic acute kidney injury

(2011) Asif A. Sharfuddin et al.   Nature Reviews Nephrology

Bioenergetics and cell death

(2010) Yulia Kushnareva et al.   Annals of the New York Academy of Sciences

Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion

(2010) E.Y. Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

(2010) M. C. Bosco et al.   BLOOD

A comprehensive genotype–phenotype interaction of different Toll-like receptor variations in a renal transplant cohort

(2010) Bernd Krüger et al.   CLINICAL SCIENCE

Nod1 and Nod2 Are Expressed in Human and Murine Renal Tubular Epithelial Cells and Participate in Renal Ischemia Reperfusion Injury

(2010) Alana A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury

(2010) Krisztina Rusai et al.   PEDIATRIC NEPHROLOGY

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

(2008) Wilco P. Pulskens et al.   PLoS One