Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies
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Title
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-16
DOI
10.3389/fimmu.2020.01185
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Note: Only part of the references are listed.- The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma
- (2019) Erik Ladomersky et al. Frontiers in Pharmacology
- Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
- (2019) Michael Platten et al. NATURE REVIEWS DRUG DISCOVERY
- Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation
- (2019) Christopher P. Stanley et al. NATURE
- IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis
- (2019) Kumar S. Bishnupuri et al. CANCER RESEARCH
- Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
- (2019) Maisa C. Takenaka et al. NATURE NEUROSCIENCE
- Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
- (2019) Georgina V Long et al. LANCET ONCOLOGY
- IDO1 in cancer: a Gemini of immune checkpoints
- (2018) Lijie Zhai et al. Cellular & Molecular Immunology
- IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma
- (2018) Erik Ladomersky et al. CLINICAL CANCER RESEARCH
- Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma
- (2018) Pravin Kesarwani et al. CLINICAL CANCER RESEARCH
- Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors
- (2018) Anthony R. Guastella et al. JOURNAL OF NEURO-ONCOLOGY
- Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond
- (2018) Alexander J. Muller et al. Seminars in Immunopathology
- The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors
- (2018) Ana C. R. Moreno et al. Frontiers in Immunology
- Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
- (2018) Paras S. Minhas et al. NATURE IMMUNOLOGY
- Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
- (2017) Mona El Refaey et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Frailty Status in Older Adults Is Related to Alterations in Indoleamine 2,3-Dioxygenase 1 and Guanosine Triphosphate Cyclohydrolase I Enzymatic Pathways
- (2017) Diego Marcos-Pérez et al. Journal of the American Medical Directors Association
- CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014
- (2017) Quinn T Ostrom et al. NEURO-ONCOLOGY
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- P53 prevent tumor invasion and metastasis by down-regulating IDO in lung cancer
- (2017) Dongfang Tang et al. Oncotarget
- The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells
- (2017) Jian Ye et al. Cell Reports
- Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance
- (2017) Marc Hennequart et al. Cancer Immunology Research
- Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?
- (2017) Francesco Fazio et al. Frontiers in Pharmacology
- Tolerogenic Phenotype of IFN-γ–Induced IDO+Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop
- (2016) Qingsheng Li et al. JOURNAL OF IMMUNOLOGY
- Advanced age negatively impacts survival in an experimental brain tumor model
- (2016) Erik Ladomersky et al. NEUROSCIENCE LETTERS
- Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment
- (2016) Cara C. Schafer et al. Oncotarget
- The aryl hydrocarbon receptor promotes aging phenotypes across species
- (2016) Anna Eckers et al. Scientific Reports
- The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas
- (2016) Jana K. Sonner et al. OncoImmunology
- IDO1 is an Integral Mediator of Inflammatory Neovascularization
- (2016) Arpita Mondal et al. EBioMedicine
- Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice
- (2015) Manabu Takamatsu et al. CANCER SCIENCE
- Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells
- (2015) April C.L. Bostian et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy
- (2015) L. Zhai et al. CLINICAL CANCER RESEARCH
- The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy
- (2015) Lijie Zhai et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels
- (2015) Kensuke Sakakibara et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy
- (2015) A. Holtzhausen et al. Cancer Immunology Research
- Tryptophan-Degrading Enzymes in Tumoral Immune Resistance
- (2015) Nicolas van Baren et al. Frontiers in Immunology
- The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
- (2015) M. D. Sharma et al. Science Advances
- Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
- (2015) Ulrike M. Litzenburger et al. Oncotarget
- Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin
- (2015) Saman Maleki Vareki et al. Oncotarget
- Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1
- (2014) Georgios Pantouris et al. AMINO ACIDS
- The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
- (2014) Brigitta Stockinger et al. Annual Review of Immunology
- Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage
- (2014) Krishna S. Tummala et al. CANCER CELL
- Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study
- (2014) E. M. Apalset et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway
- (2014) Martina Ott et al. GLIA
- IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
- (2014) Richard Metz et al. INTERNATIONAL IMMUNOLOGY
- Immunotherapy advances for glioblastoma
- (2014) D. A. Reardon et al. NEURO-ONCOLOGY
- Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases
- (2014) Jazmin Reyes Ocampo et al. Oxidative Medicine and Cellular Longevity
- Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production
- (2014) Margaret M. Lowe et al. PLoS One
- Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology
- (2014) Seray Adams et al. PLoS One
- Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues
- (2014) I. Theate et al. Cancer Immunology Research
- IDO2 in Immunomodulation and Autoimmune Disease
- (2014) George C. Prendergast et al. Frontiers in Immunology
- The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma
- (2014) Minghui Li et al. Journal for ImmunoTherapy of Cancer
- Differential expression and regulation of Tdo2 during mouse decidualization
- (2013) Dang-Dang Li et al. JOURNAL OF ENDOCRINOLOGY
- Expression of Indoleamine 2,3-Dioxygenase and Correlation With Pathological Malignancy in Gliomas
- (2013) Kentaro Mitsuka et al. NEUROSURGERY
- Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
- (2013) S. Malchow et al. SCIENCE
- Immunological and Nonimmunological Effects of Indoleamine 2,3-Dioxygenase on Breast Tumor Growth and Spontaneous Metastasis Formation
- (2012) Vera Levina et al. Clinical & Developmental Immunology
- IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival
- (2012) D. A. Wainwright et al. CLINICAL CANCER RESEARCH
- Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
- (2012) Tracy L. McGaha et al. IMMUNOLOGICAL REVIEWS
- Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
- (2012) L. Pilotte et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
- (2012) Courtney Smith et al. Cancer Discovery
- IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
- (2012) Richard Metz et al. OncoImmunology
- Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis*
- (2011) Dechaboon Changsirivathanathamrong et al. CRITICAL CARE MEDICINE
- IDO Induces Expression of a Novel Tryptophan Transporter in Mouse and Human Tumor Cells
- (2011) J. D. Silk et al. JOURNAL OF IMMUNOLOGY
- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- (2011) Christiane A. Opitz et al. NATURE
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
- (2011) Maria T Pallotta et al. NATURE IMMUNOLOGY
- Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
- (2011) Vinod P Balachandran et al. NATURE MEDICINE
- Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors
- (2011) Derek A. Wainwright et al. NEURO-ONCOLOGY
- Dioxin and immune regulation
- (2010) Nikki B. Marshall et al. Annals of the New York Academy of Sciences
- Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
- (2010) X. Liu et al. BLOOD
- 1-l-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-d-methyltryptophan
- (2010) Hajime J. Yuasa et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
- An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
- (2010) J. D. Mezrich et al. JOURNAL OF IMMUNOLOGY
- Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions
- (2010) Tony Avril et al. JOURNAL OF NEUROIMMUNOLOGY
- Kynurenine is an endothelium-derived relaxing factor produced during inflammation
- (2010) Yutang Wang et al. NATURE MEDICINE
- Accumulation of resident and peripheral dendritic cells in the aging CNS
- (2010) Ulrike W. Kaunzner et al. NEUROBIOLOGY OF AGING
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
- (2010) N. T. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling
- (2010) Brett C. DiNatale et al. TOXICOLOGICAL SCIENCES
- IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes
- (2009) F. Fallarino et al. JOURNAL OF IMMUNOLOGY
- Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy
- (2009) Takeshi Miyazaki et al. JOURNAL OF NEUROSURGERY
- A Kinetic, Spectroscopic, and Redox Study of Human Tryptophan 2,3-Dioxygenase†
- (2008) Jaswir Basran et al. BIOCHEMISTRY
- Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival
- (2008) K. Ino et al. CLINICAL CANCER RESEARCH
- Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma
- (2008) Ke Pan et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
- (2008) Karen Bulloch et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
- (2008) Francisco J. Quintana et al. NATURE
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