Orphan G Protein Coupled Receptors in Affective Disorders

Orphan G-Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

(2020) Jorge Carvalho et al.   CIRCULATION

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

A New Rapid-Acting Antidepressant

(2020) John H. Krystal et al.   CELL

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

(2020) Gina L.C. Yosten et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR56/ADGRG1 is associated with response to antidepressant treatment

(2020) Raoul Belzeaux et al.   Nature Communications

Antenatal Glucocorticoid Exposure Results in Sex-Specific and Transgenerational Changes in Prefrontal Cortex Gene Transcription that Relate to Behavioural Outcomes

(2019) Andrea Constantinof et al.   Scientific Reports

Ketamine: A Paradigm Shift for Depression Research and Treatment

(2019) John H. Krystal et al.   NEURON

The ERK Pathway: Molecular Mechanisms and Treatment of Depression

(2019) John Q. Wang et al.   MOLECULAR NEUROBIOLOGY

Uncovering the Genetic Architecture of Major Depression

(2019) Andrew M. McIntosh et al.   NEURON

Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies

(2019) Tadafumi Kato   PSYCHIATRY AND CLINICAL NEUROSCIENCES

The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex

(2019) Chenghui Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

(2019) Gabriela Pandini Silote et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Persistent adverse effects of antidepressants

(2019) Joanna Moncrieff   Epidemiology and Psychiatric Sciences

Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative

(2019) Jan Scott et al.   International Journal of Bipolar Disorders

Chronic social defeat stress induces sustained synaptic structural changes in the prefrontal cortex and amygdala

(2019) L. Colyn et al.   BEHAVIOURAL BRAIN RESEARCH

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gpr158 Deficiency Impacts Hippocampal CA1 Neuronal Excitability, Dendritic Architecture, and Affects Spatial Learning

(2019) Demirhan Çetereisi et al.   Frontiers in Cellular Neuroscience

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

(2019) Satoshi Deyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The stressed brain of humans and rodents

(2018) M. Joëls et al.   Acta Physiologica

Cocaine- and amphetamine-regulated transcript peptide (CART) induced reward behavior is mediated via G i/o dependent phosphorylation of PKA/ERK/CREB pathway

(2018) Amita R. Somalwar et al.   BEHAVIOURAL BRAIN RESEARCH

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks

(2018) Sami Ben Hamida et al.   BIOLOGICAL PSYCHIATRY

Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†

(2018) Tian Li et al.   BIOLOGY OF REPRODUCTION

Design and synthesis of 1-(1-benzothiophen-7-yl)-1 H -pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists

(2018) Takashi Nakahata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

(2018) Nava Zisapel   BRITISH JOURNAL OF PHARMACOLOGY

Tip60: updates

(2018) Ahmed H. Ghobashi et al.   JOURNAL OF APPLIED GENETICS

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Corticosteroids and the brain

(2018) Marian Joëls   JOURNAL OF ENDOCRINOLOGY

Discovery of a Potent, Selective, and Brain-Penetrant Small-Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake

(2018) Chunyang Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation

(2018) Inês Silva Amorim et al.   JOURNAL OF NEUROSCIENCE

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Sucrose preference test for measurement of stress-induced anhedonia in mice

(2018) Meng-Ying Liu et al.   Nature Protocols

Glimmers in illuminating the druggable genome

(2018) Griffin Rodgers et al.   NATURE REVIEWS DRUG DISCOVERY

Proteomic characterization of hippocampus of chronically socially isolated rats treated with fluoxetine: Depression-like behaviour and fluoxetine mechanism of action

(2018) Ivana Perić et al.   NEUROPHARMACOLOGY

Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning

(2018) Takamitsu Sano et al.   NEUROSCIENCE RESEARCH

The phoenixins: From discovery of the hormone to identification of the receptor and potential physiologic actions

(2018) Lauren M. Stein et al.   PEPTIDES

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

(2018) Argel Aguilar-Valles et al.   Nature Communications

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

(2018) Stefanie Giera et al.   eLife

Orphan receptor GPR158 controls stress-induced depression

(2018) Laurie P Sutton et al.   eLife

Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics

(2018) Wu Zheng et al.   Frontiers in Molecular Neuroscience

Lithium – pharmacological and toxicological aspects: the current state of the art

(2018) Branislava Medić et al.   CURRENT MEDICINAL CHEMISTRY

Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37

(2018) Beihui Liu et al.   GLIA

A History of the Pharmacological Treatment of Bipolar Disorder

(2018) Francisco López-Muñoz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serotonin receptors in depression and anxiety: Insights from animal studies

(2018) Elżbieta Żmudzka et al.   LIFE SCIENCES

Anxiolytics targeting GABAA receptors: Insights on etifoxine

(2018) Pierrick Poisbeau et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders

(2018) Yi Zhou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses

(2018) Giuseppe Condomitti et al.   NEURON

Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors

(2018) Cesare Orlandi et al.   NEUROPSYCHOPHARMACOLOGY

Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors

(2018) Cesare Orlandi et al.   Cell Reports

The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders

(2018) Nicolas B. Senese et al.   Frontiers in Pharmacology

GPR88 in A2A receptor-expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating

(2017) A. C. Meirsman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2 ) increases receptor signaling activity

(2017) Ryan H. Purcell et al.   HUMAN MUTATION

Dopamine System Dysregulation in Major Depressive Disorders

(2017) Pauline Belujon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Gpr158 mediates osteocalcin’s regulation of cognition

(2017) Lori Khrimian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia

(2017) Keiji Nishiyama et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of G-protein coupled receptor signalling underpinning neurobiology of mood disorders and depression

(2017) Dimitris K Grammatopoulos   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

(2017) Eero Castrén et al.   NEUROBIOLOGY OF DISEASE

A standardization of the Novelty-Suppressed Feeding Test protocol in rats

(2017) Arantxa Blasco-Serra et al.   NEUROSCIENCE LETTERS

The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

(2017) Karolina Pytka et al.   Pharmacological Reports

Folding Underlies Bidirectional Role of GPR37/Pael-R in Parkinson Disease

(2017) Lina Leinartaité et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

(2017) Atsuro Oishi et al.   Scientific Reports

The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review

(2017) Vladimir Maletic et al.   Frontiers in Psychiatry

Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173

(2016) Lauren M. Stein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist

(2016) Aura C. Meirsman et al.   BIOLOGICAL PSYCHIATRY

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

(2016) Liping Hou et al.   LANCET

Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173

(2016) Alice K. Treen et al.   MOLECULAR ENDOCRINOLOGY

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition

(2016) J Keller et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

(2016) Craig L Hyde et al.   NATURE GENETICS

Stress, glucocorticoids and memory: implications for treating fear-related disorders

(2016) Dominique de Quervain et al.   NATURE REVIEWS NEUROSCIENCE

Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex

(2016) Carolina Aguado et al.   Frontiers in Neuroanatomy

REG4 promotes peritoneal metastasis of gastric cancer through GPR37

(2016) Hexiao Wang et al.   Oncotarget

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons

(2016) Tatsuhiro Miyagi et al.   PLoS One

Effects of Phoenixin-14 on anxiolytic-like behavior in mice

(2015) J.H. Jiang et al.   BEHAVIOURAL BRAIN RESEARCH

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88

(2015) Carolyn D. Dzierba et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders

(2015) Yingzhi Bi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

GPR39 Zn2+-sensing receptor: A new target in antidepressant development?

(2015) Katarzyna Młyniec et al.   JOURNAL OF AFFECTIVE DISORDERS

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain

(2015) Cesare Orlandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system

(2015) João P. Lopes et al.   JOURNAL OF NEUROCHEMISTRY

Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics

(2015) M Alda   MOLECULAR PSYCHIATRY

Spine synapse remodeling in the pathophysiology and treatment of depression

(2015) Catharine H. Duman et al.   NEUROSCIENCE LETTERS

Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model

(2015) Massimo Ubaldi et al.   PHARMACOGENOMICS

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder

(2015) Christoph U. Correll et al.   World Psychiatry

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

(2015) Stefanie Giera et al.   Nature Communications

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

(2015) Sarah D. Ackerman et al.   Nature Communications

Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort

(2015) Joanne Ryan et al.   Brain and Behavior

Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor

(2014) Chunyang Jin et al.   ACS Chemical Neuroscience

Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52

(2014) Masaki Setoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

(2014) Shigeru Tanaka et al.   NEUROBIOLOGY OF DISEASE

Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders

(2014) Hidetoshi Komatsu et al.   PLoS One

Dual regulation of G proteins and the G-protein–activated K+channels by lithium

(2014) Isabella Farhy Tselnicker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

(2014) B.-I. Bae et al.   SCIENCE

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Manipulating melatonin in managing mood

(2013) P. Boyce et al.   ACTA PSYCHIATRICA SCANDINAVICA

The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex

(2013) N. Kurabayashi et al.   DEVELOPMENT

Side effects of antidepressants during long-term use in a naturalistic setting

(2013) Pierre M. Bet et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle developmentin vivo

(2013) Melissa P. Wu et al.   FEBS Journal

Mice lacking the Parkinson's related GPR37/PAEL receptor show non-motor behavioral phenotypes: age and gender effect

(2013) S. Mandillo et al.   GENES BRAIN AND BEHAVIOR

Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats

(2013) Zheng Huan Fang et al.   NEUROSCIENCE RESEARCH

GPR158, an Orphan Member of G Protein-Coupled Receptor Family C: Glucocorticoid-Stimulated Expression and Novel Nuclear Role

(2013) Nitin Patel et al.   PLoS One

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

(2013) Rebecca C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-linked signaling pathways in bipolar and major depressive disorders

(2013) Hiroaki Tomita et al.   Frontiers in Genetics

Association study in three different populations between the GPR88 gene and major psychoses

(2013) Maria Del Zompo et al.   Molecular Genetics & Genomic Medicine

Developmental Expression of Orphan G Protein-Coupled Receptor 50 in the Mouse Brain

(2012) Ellen Grünewald et al.   ACS Chemical Neuroscience

Synergistic mechanisms involved in the antidepressant effects of agomelatine

(2012) Daniela Tardito et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes

(2012) Cesare Orlandi et al.   JOURNAL OF CELL BIOLOGY

Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains

(2012) M. Batailler et al.   JOURNAL OF NEUROENDOCRINOLOGY

Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors

(2012) Bao-le Zhang et al.   Journal of Zhejiang University-SCIENCE B

Lithium toxicity profile: a systematic review and meta-analysis

(2012) Rebecca F McKnight et al.   LANCET

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

(2012) Albert Quintana et al.   NATURE NEUROSCIENCE

Mutation in Parkinson Disease-Associated, G-Protein-Coupled Receptor 37 (GPR37/PaelR) Is Related to Autism Spectrum Disorder

(2012) Eriko Fujita-Jimbo et al.   PLoS One

Comparative characterization of GPRC5B and GPRC5C LacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice

(2011) Takamitsu Sano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern

(2011) M. Delavest et al.   EUROPEAN PSYCHIATRY

Specific expression of GPR56 by human cytotoxic lymphocytes

(2011) Yen-Ming Peng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

(2011) Jean-Martin Beaulieu   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor

(2011) Hirohide Nambu et al.   LIFE SCIENCES

GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala

(2011) L.-L. Zhang et al.   NEUROSCIENCE

GPR50 Interacts with TIP60 to Modulate Glucocorticoid Receptor Signalling

(2011) Jian Li et al.   PLoS One

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

(2011) R. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A

(2011) Yogesh Dwivedi   Neuropsychiatric Disease and Treatment

Genome-scan for bipolar disorder with sib-pair families in the Sardinian population: A new susceptibility locus on chromosome 1p22-p21?

(2010) Maria Del Zompo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys

(2010) Rochellys Diaz Heijtz et al.   Behavioral and Brain Functions

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment

(2010) Gilberto Spadoni et al.   CNS Neuroscience & Therapeutics

Antidepressant-like behavior in brain-specific angiogenesis inhibitor 2-deficient mice

(2010) Daisuke Okajima et al.   Journal of Physiological Sciences

Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing

(2010) Daisuke Okajima et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population

(2010) Donald J. MacIntyre et al.   NEUROSCIENCE LETTERS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

A Molecular Signature of Depression in the Amygdala

(2009) Etienne Sibille et al.   AMERICAN JOURNAL OF PSYCHIATRY

GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues

(2009) Mariella Della Chiesa et al.   INTERNATIONAL IMMUNOLOGY

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?

(2009) Sheree F. Logue et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

GPR3 Receptor, a Novel Actor in the Emotional-Like Responses

(2009) Olga Valverde et al.   PLoS One

Beyond the monoaminergic hypothesis: Agomelatine, a new antidepressant with an innovative mechanism of action

(2009) Siegfried Kasper et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

(2008) Laurence Dufourny et al.   BMC EVOLUTIONARY BIOLOGY

Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression

(2008) M. Orsetti et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CART peptides: regulators of body weight, reward and other functions

(2008) G. Rogge et al.   NATURE REVIEWS NEUROSCIENCE

Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   NEUROPSYCHOPHARMACOLOGY

Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdala

(2008) J.A.J. Becker et al.   NEUROSCIENCE

Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse

(2007) Elena A. Ivanova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

(2007) Jason J. Radley et al.   JOURNAL OF COMPARATIVE NEUROLOGY