Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors

Orphan receptor GPR158 controls stress-induced depression

(2018) Laurie P Sutton et al.   eLife

Gpr158 mediates osteocalcin’s regulation of cognition

(2017) Lori Khrimian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum

(2016) Laurie P. Sutton et al.   BIOLOGICAL PSYCHIATRY

Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders

(2016) Ana M. Garcia et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons

(2016) I. Sarria et al.   JOURNAL OF NEUROSCIENCE

cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor

(2016) M Fujita et al.   MOLECULAR PSYCHIATRY

Gαi/o-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later

(2015) Tarsis F. Brust et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain

(2015) Cesare Orlandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of ventral striatal cAMP signaling in stress-induced behaviors

(2015) Florian Plattner et al.   NATURE NEUROSCIENCE

Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice

(2015) Zhen-Zhen Wang et al.   Scientific Reports

Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors

(2015) Prerana Shrestha et al.   eLife

Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT1A receptor-adenylyl cyclase axis

(2014) Adele Stewart et al.   FASEB JOURNAL

GPR179 Is Required for High Sensitivity of the mGluR6 Signaling Cascade in Depolarizing Bipolar Cells

(2014) T. A. Ray et al.   JOURNAL OF NEUROSCIENCE

Potential role of G protein-coupled receptor (GPCR) heterodimerization in neuropsychiatric disorders: A focus on depression

(2014) Kinga Szafran et al.   Pharmacological Reports

Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice

(2014) André R.S. Colla et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant-like activity of dehydrozingerone: Involvement of the serotonergic and noradrenergic systems

(2014) Débora M. Martinez et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuropathology of stress

(2013) Paul J. Lucassen et al.   ACTA NEUROPATHOLOGICA

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling

(2013) E.R. Workman et al.   NEUROPHARMACOLOGY

Monoamine neurocircuitry in depression and strategies for new treatments

(2013) Michel Hamon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The antidepressant-like action of mGlu5 receptor antagonist, MTEP, in the tail suspension test in mice is serotonin dependent

(2013) Agnieszka Pałucha-Poniewiera et al.   PSYCHOPHARMACOLOGY

G protein-linked signaling pathways in bipolar and major depressive disorders

(2013) Hiroaki Tomita et al.   Frontiers in Genetics

GPR179 Is Required for Depolarizing Bipolar Cell Function and Is Mutated in Autosomal-Recessive Complete Congenital Stationary Night Blindness

(2012) Neal S. Peachey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Exome Sequencing Identifies Mutations in GPR179 Leading to Autosomal-Recessive Complete Congenital Stationary Night Blindness

(2012) Isabelle Audo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes

(2012) Cesare Orlandi et al.   JOURNAL OF CELL BIOLOGY

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

The neurobiology of depression and antidepressant action

(2012) Paul Willner et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons

(2012) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complex of G Protein Regulator RGS9-2 and G 5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum

(2012) K. Xie et al.   Science Signaling

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

(2011) Jean-Philippe Guilloux et al.   JOURNAL OF NEUROSCIENCE METHODS

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

RGS inhibition at G i2 selectively potentiates 5-HT1A-mediated antidepressant effects

(2010) J. N. Talbot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress signalling pathways that impair prefrontal cortex structure and function

(2009) Amy F. T. Arnsten   NATURE REVIEWS NEUROSCIENCE

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

(2007) Jason J. Radley et al.   JOURNAL OF COMPARATIVE NEUROLOGY