CRISPR/Cas9 in Cancer Immunotherapy: Animal Models and Human Clinical Trials

RNA-Targeting CRISPR–Cas Systems and Their Applications

(2020) Michal Burmistrz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine

(2020) Filipe V. Jacinto et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing

(2020) Hua Alexander Han et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR

(2020) Dana Stenger et al.   BLOOD

Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy

(2020) Tao Wan et al.   JOURNAL OF CONTROLLED RELEASE

Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research

(2019) Kiyoung Eun et al.   BMC BIOTECHNOLOGY

Engineer chimeric Cas9 to expand PAM recognition based on evolutionary information

(2019) Dacheng Ma et al.   Nature Communications

Comparison of efficiency and specificity of CRISPR-associated (Cas) nucleases in plants: An expanded toolkit for precision genome engineering

(2019) Oleg Raitskin et al.   PLoS One

Evaluation and Reduction of CRISPR Off-Target Cleavage Events

(2019) Christopher A. Vakulskas et al.   Nucleic Acid Therapeutics

CRISPR Cpf1 proteins: structure, function and implications for genome editing

(2019) Fatemeh Safari et al.   Cell and Bioscience

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

(2019) Stefan Stoiber et al.   Cells

Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies

(2019) Lorraine Springuel et al.   BIODRUGS

FRK plays an oncogenic role in non‐small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming

(2019) Li Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

CAR-Based Strategies beyond T Lymphocytes: Integrative Opportunities for Cancer Adoptive Immunotherapy

(2019) Ramona Rotolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene editing for immune cell therapies

(2019) Stefanie R. Bailey et al.   NATURE BIOTECHNOLOGY

Intrinsic resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance

(2019) Santoni-Rugiu et al.   Cancers

CRISPR/Cas9-mediated Knockout and In Situ Inversion of ORF57 Gene from All Copies of The KSHV Genome in BCBL-1 Cells

(2019) Andrew BeltCappellino et al.   JOURNAL OF VIROLOGY

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

(2019) Matthew F Pech et al.   eLife

Recent advances in the CRISPR genome editing tool set

(2019) Su Bin Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning

(2019) Daqi Wang et al.   Nature Communications

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D

(2019) Jianguo Huang et al.   Scientific Reports

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma

(2019) Bryan D. Choi et al.   Journal for ImmunoTherapy of Cancer

PD-1 disrupted CAR-T cells in the treatment of solid tumors: Promises and challenges

(2019) Eileen McGowan et al.   BIOMEDICINE & PHARMACOTHERAPY

Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system

(2019) Anders W. Matson et al.   PLoS One

Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ

(2019) Xiaoxuan Zhuang et al.   Frontiers in Immunology

Solute carrier transporters: the metabolic gatekeepers of immune cells

(2019) Wenxin Song et al.   Acta Pharmaceutica Sinica B

Molecular biology at the cutting edge: A review on CRISPR/CAS9 gene editing for undergraduates

(2018) Deborah M. Thurtle-Schmidt et al.   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR

(2018) Imran Shair Mohammad et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeted genome editing in acute lymphoblastic leukemia: a review

(2018) Adrián Montaño et al.   BMC BIOTECHNOLOGY

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer

(2018) Yinnan Chen et al.   Advanced Science

Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia

(2018) Ciprian Tomuleasa et al.   Frontiers in Immunology

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

CRISPR deletion of MIEN1 in breast cancer cells

(2018) Timothy Van Treuren et al.   PLoS One

Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3′-overhang

(2018) Su Bin Moon et al.   Nature Communications

Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9

(2018) Lupeng Ye et al.   Cell Discovery

CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions

(2018) Wanghong Hu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling

(2018) Norihide Jo et al.   CANCER SCIENCE

Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality

(2018) Shuichi Watanabe et al.   INTERNATIONAL JOURNAL OF CANCER

CRISPR RNA-guided autonomous delivery of Cas9

(2018) Royce A. Wilkinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single transcript unit CRISPR 2.0 systems for robust Cas9 and Cas12a mediated plant genome editing

(2018) Xu Tang et al.   PLANT BIOTECHNOLOGY JOURNAL

Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor

(2018) Eri Saeki et al.   PLoS One

Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

(2018) Sophie Viaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR in personalized medicine: Industry perspectives in gene editing

(2018) Andrew Hong   SEMINARS IN PERINATOLOGY

CAR T Cell Therapy for Neuroblastoma

(2018) Rebecca M. Richards et al.   Frontiers in Immunology

CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

(2017) Ruisong Ye et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CRISPR–Cas systems exploit viral DNA injection to establish and maintain adaptive immunity

(2017) Joshua W. Modell et al.   NATURE

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

New variants of CRISPR RNA-guided genome editing enzymes

(2017) Jana Murovec et al.   PLANT BIOTECHNOLOGY JOURNAL

CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond

(2017) ZeNan L. Chang et al.   TRENDS IN MOLECULAR MEDICINE

Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease

(2017) Uri Netz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer

(2016) Benjamin H. Lok et al.   CLINICAL CANCER RESEARCH

Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy

(2016) Stephanie M Myers et al.   Future Medicinal Chemistry

Kinesin-5 inhibitor resistance is driven by kinesin-12

(2016) Emma G. Sturgill et al.   JOURNAL OF CELL BIOLOGY

Genome-editing Technologies for Gene and Cell Therapy

(2016) Morgan L Maeder et al.   MOLECULAR THERAPY

Providing Appropriate Risk Information on Genome Editing for Patients

(2016) Motoko Araki et al.   TRENDS IN BIOTECHNOLOGY

A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer

(2016) J. Vijai et al.   Cancer Discovery

MUC1 stimulates EGFR expression and function in endometrial cancer

(2016) Brian J. Engel et al.   Oncotarget

The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer

(2016) Umar Raza et al.   Oncotarget

Toxicity and management in CAR T-cell therapy

(2016) Challice L Bonifant et al.   Molecular Therapy-Oncolytics

CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients

(2016) Shu Su et al.   Scientific Reports

The CRISPR-Cas immune system: Biology, mechanisms and applications

(2015) Devashish Rath et al.   BIOCHIMIE

TP53: an oncogene in disguise

(2015) T Soussi et al.   CELL DEATH AND DIFFERENTIATION

Standards needed for gene-editing errors

(2015) J. Keith Joung   NATURE

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells

(2015) Norihiko Kawamura et al.   Oncotarget

Mechanism of spacer integration links the CRISPR/Cas system to transposition as a form of mobile DNA

(2015) Fred Dyda et al.   Mobile DNA

Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

(2014) David G. McFadden et al.   CELL

Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes

(2014) Shuo-Ting Yen et al.   DEVELOPMENTAL BIOLOGY

DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets

(2014) Corynn Kasap et al.   Nature Chemical Biology

Asymmetric parental genome engineering by Cas9 during mouse meiotic exit

(2014) Toru Suzuki et al.   Scientific Reports

The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems

(2013) Krzysztof Chylinski et al.   RNA Biology

The Perioperative Period is an Underutilized Window of Therapeutic Opportunity in Patients With Colorectal Cancer

(2009) Gerben J. van der Bij et al.   ANNALS OF SURGERY

The ethics of human gene transfer

(2008) Jonathan Kimmelman   NATURE REVIEWS GENETICS