CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

(2020) Maximilian M. L. Knott et al.   CANCER AND METASTASIS REVIEWS

CDK9 Blockade Exploits Context-Dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma

(2020) Guillermo Flores et al.   MOLECULAR CANCER THERAPEUTICS

Translational genomics of malignant rhabdoid tumours: Current impact and future possibilities

(2020) Martina A. Finetti et al.   SEMINARS IN CANCER BIOLOGY

Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy

(2020) Jonathan Chou et al.   Cancer Discovery

Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma

(2020) Günther H.S. Richter et al.   Cancers

Rhabdomyosarcoma

(2019) Stephen X. Skapek et al.   Nature Reviews Disease Primers

A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis

(2019) Dan Yu et al.   NUCLEIC ACIDS RESEARCH

Chemical genomics reveals histone deacetylases are required for core regulatory transcription

(2019) Berkley E. Gryder et al.   Nature Communications

Organization and regulation of gene transcription

(2019) Patrick Cramer   NATURE

Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

(2019) Berkley E. Gryder et al.   NATURE GENETICS

Epigenetic Targets in Synovial Sarcoma: A Mini-Review

(2019) Ryland Hale et al.   Frontiers in Oncology

Compare and contrast: pediatric cancer versus adult malignancies

(2019) Patricia Kattner et al.   CANCER AND METASTASIS REVIEWS

Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia

(2019) Raoul Tibes et al.   Frontiers in Oncology

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

(2018) Matthew J. McBride et al.   CANCER CELL

EWS/ETS-driven Ewing Sarcoma requires BET bromodomain proteins

(2018) Paradesi Naidu Gollavilli et al.   CANCER RESEARCH

The landscape of genomic alterations across childhood cancers

(2018) Susanne N. Gröbner et al.   NATURE

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

(2018) Jinlei Bian et al.   BIOORGANIC CHEMISTRY

Open questions: why are babies rarely born with cancer?

(2018) Michelle Monje   BMC BIOLOGY

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

(2018) Hanghang Zhang et al.   CELL

Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma

(2018) Xiaoyang Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs

(2018) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Inhibitors of cyclin-dependent kinases as cancer therapeutics

(2017) Steven R. Whittaker et al.   PHARMACOLOGY & THERAPEUTICS

PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability

(2017) Berkley E. Gryder et al.   Cancer Discovery

Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors

(2017) Natalia Moreno et al.   Oncotarget

Discovery of novel indirubin-3′-monoxime derivatives as potent inhibitors against CDK2 and CDK9

(2015) Lei Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart

(2015) G. Matrone et al.   JOURNAL OF CELL SCIENCE

Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor

(2015) Frédéric Coin et al.   MOLECULAR CELL

Getting up to speed with transcription elongation by RNA polymerase II

(2015) Iris Jonkers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

(2015) Tim Hensel et al.   Oncotarget

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

(2015) Huasong Lu et al.   eLife

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

(2014) Nicolò Riggi et al.   CANCER CELL

New Strategies in Ewing Sarcoma: Lost in Translation?

(2014) F. I. Arnaldez et al.   CLINICAL CANCER RESEARCH

Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263

(2014) Gernot Polier et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel CDK9 Inhibitor Shows Potent Antitumor Efficacy in Preclinical Hematologic Tumor Models

(2014) T. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

(2014) J. F. Shern et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor

(2013) T K Albert et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Subnuclear distribution of SSX regulates its function

(2013) Jiaochen Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

(2013) Ryan P. McNamara et al.   Cell Reports

Synovial sarcoma in children and adolescents: A critical reappraisal of staging investigations in relation to the rate of metastatic involvement at diagnosis

(2012) Andrea Ferrari et al.   EUROPEAN JOURNAL OF CANCER

Salvage rates and prognostic factors after relapse in children and adolescents with initially localised synovial sarcoma

(2012) Andrea Ferrari et al.   EUROPEAN JOURNAL OF CANCER

PAX3/FOXO1Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification

(2012) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcription factors: from enhancer binding to developmental control

(2012) François Spitz et al.   NATURE REVIEWS GENETICS

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SS18 Together with Animal-Specific Factors Defines Human BAF-Type SWI/SNF Complexes

(2012) Evelien Middeljans et al.   PLoS One

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo

(2011) L Raimondi et al.   CELL DEATH AND DIFFERENTIATION

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol

(2011) Xiangrui Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

(2011) G Polier et al.   Cell Death & Disease

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

(2010) Gaetano Romano et al.   CELL CYCLE

Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3′ end processing through p21, NPAT and CDK9

(2010) J Pirngruber et al.   ONCOGENE

Synovial Sarcoma is a Stem Cell Malignancy

(2010) Norifumi Naka et al.   STEM CELLS

Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005

(2009) Iyad Sultan et al.   CANCER

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells

(2009) Sungyoo Cho et al.   EMBO JOURNAL

Selective control of gene expression by CDK9 in human cells

(2009) Judit Garriga et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation

(2009) Riccardo Taulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Flavopiridol, Fludarabine, and Rituximab in Mantle Cell Lymphoma and Indolent B-Cell Lymphoproliferative Disorders

(2009) Thomas S. Lin et al.   JOURNAL OF CLINICAL ONCOLOGY

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL

PP2B and PP1  cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

(2008) R. Chen et al.   GENES & DEVELOPMENT

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY