Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor

Blockbuster dreams for Pfizer's CDK inhibitor

(2013) Malini Guha   NATURE BIOTECHNOLOGY

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Structural basis of transcription elongation

(2012) Fuensanta W. Martinez-Rucobo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development

(2012) Valentina Caracciolo et al.   CELL CYCLE

Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia

(2012) J. E. Karp et al.   HAEMATOLOGICA

Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase

(2012) Douglas M. Jacobsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Promoter proximal pausing and the control of gene expression

(2011) Jian Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity

(2011) Fuensanta W Martinez-Rucobo et al.   EMBO JOURNAL

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol

(2011) Xiangrui Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation

(2011) Stefania Bottardi et al.   NUCLEIC ACIDS RESEARCH

Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

(2011) Zhao Qin Bao et al.   STRUCTURE

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells

(2010) Thomas K Albert et al.   GENOME BIOLOGY

Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli

(2009) Miranda L. Cox et al.   CELLULAR SIGNALLING

RNA Polymerase II C-terminal Heptarepeat Domain Ser-7 Phosphorylation Is Established in a Mediator-dependent Fashion

(2009) Stefan Boeing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective control of gene expression by CDK9 in human cells

(2009) Judit Garriga et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Defining mechanisms that regulate RNA polymerase II transcription in vivo

(2009) Nicholas J. Fuda et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology

(2008) S WANG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES