Medicinal Plants as Sources of Active Molecules Against COVID-19

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

(2020) Jin-jin Zhang et al.   ALLERGY

Structure analysis of the receptor binding of 2019-nCoV

(2020) Yun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapid discrimination of Salvia miltiorrhiza according to their geographical regions by laser induced breakdown spectroscopy (LIBS) and particle swarm optimization-kernel extreme learning machine (PSO-KELM)

(2020) Jing Liang et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs

(2020) Hui Luo et al.   Chinese Journal of Integrative Medicine

The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options

(2020) Suliman Khan et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

(2020) Jiabao Xu et al.   Viruses-Basel

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

A potential role for integrins in host cell entry by SARS-CoV-2

(2020) Christian JA Sigrist et al.   ANTIVIRAL RESEARCH

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties

(2020) Cornelis Smit et al.   CLINICAL PHARMACOKINETICS

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

Comparison of the COVID-2019 (SARS-CoV-2) pathogenesis with SARS-CoV and MERS-CoV infections

(2020) Mona Fani et al.   Future Virology

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

Eckol from Ecklonia cava ameliorates TNF-α/IFN-γ-induced inflammatory responses via regulating MAPKs and NF-κB signaling pathway in HaCaT cells

(2020) Su-Hyeon Cho et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

(2020) Jrhau Lung et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical features and treatment of COVID-19 patients in northeast Chongqing

(2020) Suxin Wan et al.   JOURNAL OF MEDICAL VIROLOGY

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

(2020) Ye Qiu et al.   MICROBES AND INFECTION

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Drug treatment options for the 2019-new coronavirus (2019-nCoV)

(2020) Hongzhou Lu   BioScience Trends

Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment

(2020) Zhenwei Wang et al.   BioScience Trends

Repurposing antimalarials and other drugs for COVID-19

(2020) Patricia Schlagenhauf et al.   Travel Medicine and Infectious Disease

Identification of a Pharmacological Biomarker for the Bioassay-Based Quality Control of a Thirteen-Component TCM Formula (Lianhua Qingwen) Used in Treating Influenza A Virus (H1N1) Infection

(2020) Dan Gao et al.   Frontiers in Pharmacology

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far

(2020) Firas A. Rabi et al.   Pathogens

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

SmKSL overexpression combined with elicitor treatment enhances tanshinone production from Salvia miltiorrhiza hairy roots

(2020) Tao Wei et al.   BIOCHEMICAL ENGINEERING JOURNAL

Anti-inflammatory activity in vitro, extractive process and HPLC-MS characterization of total saponins extract from Tribulus terrestris L. fruits

(2020) Chunlian Tian et al.   INDUSTRIAL CROPS AND PRODUCTS

The effect of polysaccharides from Cibotium barometz on enhancing temozolomide–induced glutathione exhausted in human glioblastoma U87 cells, as revealed by 1H NMR metabolomics analysis

(2020) Yue Shi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

(2020) Li Runfeng et al.   PHARMACOLOGICAL RESEARCH

Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses

(2020) Shibo Jiang et al.   TRENDS IN IMMUNOLOGY

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice

(2019) Beodeul Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

Biosynthesis of large-sized silver nanoparticles using Angelica keiskei extract and its antibacterial activity and mechanisms investigation

(2019) Juan Du et al.   MICROCHEMICAL JOURNAL

Identification and analysis of cardiac glycosides in Loranthaceae parasites Taxillus chinensis (DC.) Danser and Scurrula parasitica Linn. and their host Nerium indicum Mill.

(2019) Renyuan Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Anti-diabetic compounds from the seeds of Psoralea corylifolia

(2019) Gaohui Zhu et al.   FITOTERAPIA

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

(2019) Jing-Ru Weng et al.   VIRUS RESEARCH

Kaempferol Promotes Apoptosis While Inhibiting Cell Proliferation via Androgen-Dependent Pathway and Suppressing Vasculogenic Mimicry and Invasion in Prostate Cancer

(2019) Jun Da et al.   Analytical Cellular Pathology

Best practice in research – Overcoming common challenges in phytopharmacological research

(2019) Michael Heinrich et al.   JOURNAL OF ETHNOPHARMACOLOGY

Subchronic toxicity evaluation of ethanol extract of Cassia tora L. seeds in rats

(2019) Mu-Jin Lee et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

(2018) Min-Han Lin et al.   ANTIVIRAL RESEARCH

Chemical composition and antioxidant activity of the endemic Crataegus microphylla Koch subsp. malyana K. I. Chr. & Janjić from Bosnia

(2018) Amira Čopra-Janićijević et al.   INDUSTRIAL CROPS AND PRODUCTS

Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury

(2018) Jae-Won Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Enzymatic extract from Ecklonia cava : Acute and subchronic oral toxicity and genotoxicity studies

(2018) Jun-Won Yun et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Application of Quercus infectoria extract as a natural antimicrobial agent for chicken egg decontamination

(2018) Ahmed A. Tayel et al.   REVISTA ARGENTINA DE MICROBIOLOGIA

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

(2018) Kenza Mamouni et al.   NEOPLASIA

Effects of Rhizome Extract of Dioscorea batatas and Its Active Compound, Allantoin, on the Regulation of Myoblast Differentiation and Mitochondrial Biogenesis in C2C12 Myotubes

(2018) Junnan Ma et al.   MOLECULES

Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro

(2018) Jin Hua Chi et al.   BIOMEDICINE & PHARMACOTHERAPY

Antiviral and Antioxidant Properties of Echinochrome A

(2018) Sergey Fedoreyev et al.   Marine Drugs

Comprehensive review of antimicrobial activities of plant flavonoids

(2018) Ireneusz Górniak et al.   PHYTOCHEMISTRY REVIEWS

Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism

(2017) Gema Pereira-Caro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ethnopharmacological studies of indigenous medicinal plants in the south of Kerman, Iran

(2017) Mohammad Sadat-Hosseini et al.   JOURNAL OF ETHNOPHARMACOLOGY

Extraction and Identification of Phlorotannins from the Brown Alga, Sargassum fusiforme (Harvey) Setchell

(2017) Yajing Li et al.   Marine Drugs

Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers

(2016) Giulia Corona et al.   BRITISH JOURNAL OF NUTRITION

A network analysis of the Chinese medicine Lianhua-Qingwen formula to identify its main effective components

(2016) Chun-Hua Wang et al.   Molecular BioSystems

Regulation of protein-ligand binding affinity by hydrogen bond pairing

(2016) D. Chen et al.   Science Advances

A molecular arms race between host innate antiviral response and emerging human coronaviruses

(2016) Lok-Yin Roy Wong et al.   VIROLOGICA SINICA

Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants

(2015) Megan Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Antiviral Activity of Paulownia tomentosa against Enterovirus 71 of Hand, Foot, and Mouth Disease

(2015) Ping Ji et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Chalcones isolated fromAngelica keiskeiinhibit cysteine proteases of SARS-CoV

(2015) Ji-Young Park et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Papain-Like Protease (PLpro) Inhibitory Effects of Cinnamic Amides from Tribulus terrestris Fruits

(2014) Yeong Hun Song et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

p53 Degradation by a Coronavirus Papain-like Protease Suppresses Type I Interferon Signaling

(2014) Lin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ethnobotanical study of medicinal plants of Sirjan in Kerman Province, Iran

(2014) F. Khajoei Nasab et al.   JOURNAL OF ETHNOPHARMACOLOGY

Green biosynthesis of silver nanoparticles using Torreya nucifera and their antibacterial activity

(2014) Duraisamy Kalpana et al.   Arabian Journal of Chemistry

Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from the edible brown algae Ecklonia cava

(2013) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

(2013) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of Angiotensin Converting Enzyme, Angiotensin II Receptor Blocking, and Blood Pressure Lowering Bioactivity across Plant Families

(2013) Glen S. Patten et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula

(2013) Jianglong Song et al.   Evidence-based Complementary and Alternative Medicine

Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds ofPsoralea corylifolia

(2013) Dae Wook Kim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms

(2013) A. O. Adedeji et al.   JOURNAL OF VIROLOGY

Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay

(2013) Niusha Sharifi et al.   DARU-Journal of Pharmaceutical Sciences

Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus

(2012) Ji-Young Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases

(2012) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

(2012) Mi-Sun Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

(2012) Thi Thanh Hanh Nguyen et al.   BIOTECHNOLOGY LETTERS

Polyphenol-Rich Fraction of Brown AlgaEcklonia cavaCollected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice

(2012) Eun Young Park et al.   Evidence-based Complementary and Alternative Medicine

Comparison of neuroprotective effects of five major lipophilic diterpenoids from Danshen extract against experimentally induced transient cerebral ischemic damage

(2012) Ok Kyu Park et al.   FITOTERAPIA

Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells

(2011) Defeng Xu et al.   CANCER LETTERS

Simultaneous Analysis of Seven Bioactive Compounds inSambucus Chinensis Lindlby HPLC

(2010) Tianhong Zhang et al.   ANALYTICAL LETTERS

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model

(2009) Qi Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

(2009) A. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA