Pathological Aspects of COVID-19 as a Conformational Disease and the Use of Pharmacological Chaperones as a Potential Therapeutic Strategy

Alpha 1-Antitrypsin Deficiency: A Disorder of Proteostasis-Mediated Protein Folding and Trafficking Pathways

(2020) Esra Karatas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Surfactant replacement therapy: from biological basis to current clinical practice

(2020) Roland Hentschel et al.   PEDIATRIC RESEARCH

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city

(2020) Rui Zhang et al.   EUROPEAN RADIOLOGY

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

(2020) Guoping Li et al.   JOURNAL OF AUTOIMMUNITY

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Smell and taste dysfunction in patients with COVID-19

(2020) Michael S Xydakis et al.   LANCET INFECTIOUS DISEASES

Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue

(2020) Erdi Sozen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility

(2020) Melissa M. Arons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Ongoing Clinical Trials for the Management of the COVID-19 Pandemic

(2020) Mark P. Lythgoe et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Clinical and pathological investigation of patients with severe COVID-19

(2020) Shaohua Li et al.   JCI Insight

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

(2019) Oleksiy Klymenko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

COPII‐mediated trafficking at the ER/ERGIC interface

(2019) Jennifer Peotter et al.   TRAFFIC

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus

(2019) To Sing Fung et al.   VIROLOGY

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

(2019) Samuel Lara-Reyna et al.   Frontiers in Immunology

The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells

(2019) Chun-Chih Tseng et al.   NEOPLASIA

Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex

(2019) Hiroshi Kokubun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

(2019) Magdalena Kusaczuk   Cells

AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis

(2018) Ji-qiang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway

(2018) Daniel Hughes et al.   FEBS Journal

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

(2018) Hin Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS signaling and ER stress in cardiovascular disease

(2018) Cristhiaan D. Ochoa et al.   MOLECULAR ASPECTS OF MEDICINE

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling

(2018) Yuan-Li Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACE-2/ANG1-7 ameliorates ER stress-induced apoptosis in seawater aspiration-induced acute lung injury

(2018) MinLong Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decreased Protein Quality Control Promotes the Cognitive Dysfunction Associated With Aging and Environmental Insults

(2018) Hisayo Jin et al.   Frontiers in Neuroscience

Endoplasmic reticulum stress in the pathogenesis of hypertension

(2017) Colin N. Young   EXPERIMENTAL PHYSIOLOGY

Structural basis for perception of diverse chemical substances by T1r taste receptors

(2017) Nipawan Nuemket et al.   Nature Communications

The Role of BiP Retrieval by the KDEL Receptor in the Early Secretory Pathway and its Effect on Protein Quality Control and Neurodegeneration

(2017) Hisayo Jin et al.   Frontiers in Molecular Neuroscience

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

(2017) Kyung-Won Park et al.   Scientific Reports

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity

(2016) Yaqin Chen et al.   Scientific Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Japanese encephalitis virus induces apoptosis by the IRE1/JNK pathway of ER stress response in BHK-21 cells

(2015) Mingjie Huang et al.   ARCHIVES OF VIROLOGY

BRICHOS binds to a designed amyloid-forming  -protein and reduces proteasomal inhibition and aggresome formation

(2015) L. Dolfe et al.   BIOCHEMICAL JOURNAL

Clinical and ultrastructural spectrum of diffuse lung disease associated with surfactant protein C mutations

(2015) Donatella Peca et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

(2015) A. E. Elia et al.   EUROPEAN JOURNAL OF NEUROLOGY

Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway

(2015) Eike R. Hrincius et al.   Cell Reports

Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP

(2014) Hisayo Jin et al.   PLoS One

Abrogation of ER stress-induced apoptosis of alveolar epithelial cells by angiotensin 1–7

(2013) Bruce D. Uhal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

The interplay between endoplasmic reticulum stress and inflammation

(2012) Sumaira Z Hasnain et al.   IMMUNOLOGY AND CELL BIOLOGY

Endoplasmic reticulum stress and hypertension — a new paradigm?

(2012) Alyssa H. Hasty et al.   JOURNAL OF CLINICAL INVESTIGATION

Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus

(2012) M. Fukushi et al.   JOURNAL OF VIROLOGY

The endoplasmic reticulum stress response in aging and age-related diseases

(2012) Marishka K. Brown et al.   Frontiers in Physiology

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

Dysfunction of the ER chaperone BiP accelerates the renal tubular injury

(2008) Keita Kimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis

(2008) Zhongde Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS