Immunomodulatory and Anti-Inflammatory Strategies to Reduce Comorbidity Risk in People with HIV

Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial

(2020) Jason V Baker et al.   Open Forum Infectious Diseases

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis

(2019) Samuel P. Costello et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART

(2019) Sonia Zicari et al.   Viruses-Basel

Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use

(2019) P. Maggi et al.   AIDS Research and Therapy

Targeting thrombogenicity and inflammation in chronic HIV infection

(2019) Meagan P. O’Brien et al.   Science Advances

The Potential Protective Role of Vitamin D Supplementation on HIV-1 Infection

(2019) Natalia Alvarez et al.   Frontiers in Immunology

Metformin Reduces CD4 T-Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

(2019) Cecilia Shikuma et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Brief Report

(2019) Sahera Dirajlal-Fargo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial

(2019) Takara L Stanley et al.   Lancet HIV

Global Burden of Atherosclerotic Cardiovascular Disease in People Living with the Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis

(2018) Anoop S. V. Shah et al.   CIRCULATION

Semaglutide for type 2 diabetes mellitus: A systematic review and meta-analysis

(2018) Panagiotis Andreadis et al.   DIABETES OBESITY & METABOLISM

Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV

(2018) Suman Srinivasa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D supplementation, bone turnover, and inflammation in HIV-infected patients

(2018) L. Benguella et al.   MEDECINE ET MALADIES INFECTIEUSES

Safety and Impact of Low-Dose Methotrexate on Endothelial Function and Inflammation in Individuals with Treated Human Immunodeficiency Virus: AIDS Clinical Trials Group Study A5314

(2018) Priscilla Y HSUE et al.   CLINICAL INFECTIOUS DISEASES

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

(2018) Michael S. Saag et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases

(2018) Yusuf Nazir et al.   Biomed Research International

Anti-inflammatory therapy in well controlled HIV infection

(2018) Philip E Tarr et al.   Lancet HIV

Vorapaxar for HIV-associated inflammation and coagulopathy (ADVICE): a randomised, double-blind, placebo-controlled trial

(2018) Stephen J Kent et al.   Lancet HIV

IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection

(2018) Priscilla Y. Hsue et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Alirocumab Reduces Fatal and Nonfatal Cardiovascular Events

(2018) Michael Szarek et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1β in a Human Tonsil Explant Model

(2018) Alexandra Y. Soare et al.   JOURNAL OF VIROLOGY

Statin Prescribing Practices in the Comprehensive Care for HIV-Infected Patients

(2017) Sean G. Kelly et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

(2017) Melissa E. Schechter et al.   Science Translational Medicine

Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs

(2017) Sébastien Pasquereau et al.   Viruses-Basel

Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) in HIV

(2017) Jürgen Kurt Rockstroh   Current HIV/AIDS Reports

Pitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial

(2017) Judith A Aberg et al.   Lancet HIV

Vitamin D Supplementation Does Not Affect Metabolic Changes Seen With ART Initiation

(2017) Josh Muhammad et al.   Open Forum Infectious Diseases

A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy

(2017) Meagan P. O’Brien et al.   Open Forum Infectious Diseases

Serum oxidized low-density lipoprotein decreases in response to statin therapy and relates independently to reductions in coronary plaque in patients with HIV

(2016) Eric Nou et al.   AIDS

A pilot trial of pentoxifylline on endothelial function and inflammation in HIV-infected patients initiating antiretroviral therapy

(2016) Samir K. Gupta et al.   AIDS

Rosuvastatin slows progression of subclinical atherosclerosis in patients with treated HIV infection

(2016) Chris T. Longenecker et al.   AIDS

The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1

(2016) Jeffrey M. Jacobson et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

(2016) Cynthia L. Monaco et al.   Cell Host & Microbe

Statin Utilization and Recommendations Among HIV- and HCV-infected Veterans: A Cohort Study

(2016) Meredith E. Clement et al.   CLINICAL INFECTIOUS DISEASES

Body Composition Changes After Initiation of Raltegravir or Protease Inhibitors: ACTG A5260s

(2016) Grace A. McComsey et al.   CLINICAL INFECTIOUS DISEASES

Telmisartan increases vascular reparative capacity in older HIV-infected adults: a pilot study

(2016) Jordan E. Lake et al.   HIV CLINICAL TRIALS

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

A PRISMA-compliant systematic review and meta-analysis of randomized controlled trials investigating the effects of statin therapy on plasma lipid concentrations in HIV-infected patients

(2016) Maciej Banach et al.   PHARMACOLOGICAL RESEARCH

The effect of probiotics on CD4 counts among people living with HIV: a systematic review

(2016) H. Miller et al.   Beneficial Microbes

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

(2016) Nadja B. Kristensen et al.   Genome Medicine

HIV and Hepatitis C–Coinfected Patients Have Lower Low‐Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent “PCSK9–Lipid Paradox”

(2016) Payal Kohli et al.   Journal of the American Heart Association

One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study

(2016) Christina Psomas et al.   EBioMedicine

Gut Microbiota Linked to Sexual Preference and HIV Infection

(2016) Marc Noguera-Julian et al.   EBioMedicine

Gut microbiota diversity predicts immune status in HIV-1 infection

(2015) Piotr Nowak et al.   AIDS

Low-Density Lipoprotein Cholesterol Levels and Statin Treatment by HIV Status Among Multicenter AIDS Cohort Study Men

(2015) Anne K. Monroe et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Long term effect of telmisartan in HIV-positive male patients with high blood pressure

(2015) Claudio Ucciferri et al.   Brazilian Journal of Infectious Diseases

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition

(2015) Nathalie Bergeron et al.   CIRCULATION

Extended-Release Niacin Versus Fenofibrate in HIV-Infected Participants With Low High-Density Lipoprotein Cholesterol: Effects on Endothelial Function, Lipoproteins, and Inflammation

(2015) Michael P. Dubé et al.   CLINICAL INFECTIOUS DISEASES

Telmisartan to reduce cardiovascular risk in older HIV-infected adults: a pilot study

(2015) Jordan E. Lake et al.   HIV CLINICAL TRIALS

Rosuvastatin Reduces Vascular Inflammation and T-cell and Monocyte Activation in HIV-Infected Subjects on Antiretroviral Therapy

(2015) Nicholas T. Funderburg et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART

(2015) Birgitte Stiksrud et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Exploring Statins to Decrease HIV-Related Heart Disease Risk

(2015) Mike Mitka   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity Among HIV-Infected Adults Receiving Medical Care in the United States

(2015) Angela M. Thompson-Paul et al.   MEDICINE

Dysbiotic bacteria translocate in progressive SIV infection

(2015) Z Klase et al.   Mucosal Immunology

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques

(2015) A M Ortiz et al.   Mucosal Immunology

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

(2015) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Probiotic Supplement on Cytokine Levels in HIV-Infected Individuals: A Preliminary Study

(2015) Katia Falasca et al.   Nutrients

Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial

(2015) Janet Lo et al.   Lancet HIV

Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the “Probio-HIV” Clinical Trial

(2015) Gabriella d’Ettorre et al.   PLoS One

2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III cholesterol guidelines applied to HIV-infected patients with/without subclinical high-risk coronary plaque

(2014) Markella V. Zanni et al.   AIDS

Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy

(2014) Véronique Fabre-Mersseman et al.   AIDS

Immunomodulation of Antiretroviral Drug-Suppressed Chronic HIV-1 Infection in an Oral Probiotic Double-Blind Placebo-Controlled Trial

(2014) Otto O. Yang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Associations Between HIV Infection and Subclinical Coronary Atherosclerosis

(2014) Wendy S. Post et al.   ANNALS OF INTERNAL MEDICINE

Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk

(2014) Rajiv Chowdhury et al.   ANNALS OF INTERNAL MEDICINE

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

(2014) E. M. Sparkenbaugh et al.   BLOOD

Rosuvastatin Preserves Renal Function and Lowers Cystatin C in HIV-Infected Subjects on Antiretroviral Therapy: The SATURN-HIV Trial

(2014) Chris T. Longenecker et al.   CLINICAL INFECTIOUS DISEASES

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy

(2014) J-P Routy et al.   HIV MEDICINE

Increased Arterial Inflammation Relates to High-risk Coronary Plaque Morphology in HIV-Infected Patients

(2014) Ahmed Tawakol et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation

(2014) Takara L. Stanley et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

(2014) Jan Kristoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of 24 Weeks of Statin Therapy on Systemic and Vascular Inflammation in HIV-Infected Subjects Receiving Antiretroviral Therapy

(2014) A. R. Eckard et al.   JOURNAL OF INFECTIOUS DISEASES

Rifaximin has a Marginal Impact on Microbial Translocation, T-cell Activation and Inflammation in HIV-Positive Immune Non-responders to Antiretroviral Therapy – ACTG A5286

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection

(2014) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

(2014) Duy M. Dinh et al.   JOURNAL OF INFECTIOUS DISEASES

Decreases in Colonic and Systemic Inflammation in Chronic HIV Infection after IL-7 Administration

(2014) Irini Sereti et al.   PLoS Pathogens

Metabolic Consequences of HIV: Pathogenic Insights

(2014) Amanda L. Willig et al.   Current HIV/AIDS Reports

Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men

(2013) Markella V. Zanni et al.   AIDS

Response to Newly Prescribed Lipid-Lowering Therapy in Patients With and Without HIV Infection

(2013) Michael J. Silverberg   ANNALS OF INTERNAL MEDICINE

Fecal Microbiota Therapy for RecurrentClostridium difficileInfection in HIV-Infected Persons

(2013) Latesha Elopre et al.   ANNALS OF INTERNAL MEDICINE

Alterations in the Gut Microbiota Associated with HIV-1 Infection

(2013) Catherine A. Lozupone et al.   Cell Host & Microbe

Rosuvastatin Treatment Reduces Markers of Monocyte Activation in HIV-Infected Subjects on Antiretroviral Therapy

(2013) N. T. Funderburg et al.   CLINICAL INFECTIOUS DISEASES

Role of the Gut Microbiota in the Development and Function of Lymphoid Cells

(2013) N. Kamada et al.   JOURNAL OF IMMUNOLOGY

Noncalcified Coronary Atherosclerotic Plaque and Immune Activation in HIV-Infected Women

(2013) Kathleen V. Fitch et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolic disease in HIV infection

(2013) Jordan E Lake et al.   LANCET INFECTIOUS DISEASES

TNF and TNF Receptor Superfamily Members in HIV infection: New Cellular Targets for Therapy?

(2013) Amit Kumar et al.   MEDIATORS OF INFLAMMATION

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

(2013) Ivan Vujkovic-Cvijin et al.   Science Translational Medicine

HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota

(2013) Ian H McHardy et al.   Microbiome

Microbial Translocation Across the GI Tract

(2012) Jason M. Brenchley et al.   Annual Review of Immunology

IL-7 induces expression and activation of integrin  4 7 promoting naive T-cell homing to the intestinal mucosa

(2012) R. Cimbro et al.   BLOOD

The impact of blood coagulability on atherosclerosis and cardiovascular disease

(2012) R. LOEFFEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Omega-3 Fatty Acids Do Not Improve Endothelial Function In Virologically Suppressed HIV-Infected Men: A Randomized Placebo-Controlled Trial

(2011) Corrilynn O. Hileman et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

Systematic Review of Intestinal Microbiota Transplantation (Fecal Bacteriotherapy) for Recurrent Clostridium difficile Infection

(2011) Ethan Gough et al.   CLINICAL INFECTIOUS DISEASES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial

(2011) A Gori et al.   Mucosal Immunology

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Probiotic yogurt consumption may improve gastrointestinal symptoms, productivity, and nutritional intake of people living with human immunodeficiency virus in Mwanza, Tanzania

(2011) Stephanie L. Irvine et al.   NUTRITION RESEARCH

Effect of Probiotic Bacteria on Microbial Host Defense, Growth, and Immune Function in Human Immunodeficiency Virus Type-1 Infection

(2011) Susanna Cunningham-Rundles et al.   Nutrients

Short-term effects of extended-release niacin on endothelial function in HIV-infected patients on stable antiretroviral therapy

(2010) Dominic C Chow et al.   AIDS

Impact of NRTIs on lipid levels among a large HIV-infected cohort initiating antiretroviral therapy in clinical care

(2010) Heidi M Crane et al.   AIDS

Effects of a Growth Hormone-Releasing Hormone Analog on Endogenous GH Pulsatility and Insulin Sensitivity in Healthy Men

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity

(2010) Diane L. Kamen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

(2010) Aisha Nazli et al.   PLoS Pathogens

Angiotensin II receptor antagonism with telmisartan increases number of endothelial progenitor cells in normotensive patients with coronary artery disease: A randomized, double-blind, placebo-controlled study

(2009) Francesco Pelliccia et al.   ATHEROSCLEROSIS

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Prevention of insulin resistance by n-3 polyunsaturated fatty acids

(2009) Dawn Fedor et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Nonconcordance between subclinical atherosclerosis and the calculated Framingham risk score in HIV-infected patients: relationships with serum markers of oxidation and inflammation

(2009) S Parra et al.   HIV MEDICINE

Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohnʼs disease

(2009) Alan L. Buchman et al.   INFLAMMATORY BOWEL DISEASES

Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation

(2008) Julian Falutz et al.   AIDS

Endotoxin-Binding Affinity of Sevelamer Hydrochloride

(2008) Mary C. Perianayagam et al.   AMERICAN JOURNAL OF NEPHROLOGY

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

GH/GHRH axis in HIV lipodystrophy

(2008) Takara L. Stanley et al.   Pituitary